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To know the incidence of leiomyoma in hysterectomy specimens and study the degenerative changes of leiomyoma and its variants. A prospective study of 1000 hysterectomy specimens was done. All the chief complaints, gross features and microscopic findings were recorded. The most common benign lesion found was leiomyoma in 55.4% cases followed by adenomyosis in 32.5% cases. Majority of leiomyoma cases (99.2%) were usual leiomyoma. 2 variants of leiomyoma, 1 case of cellular leiomyoma and other case of mitotically active leiomyoma were found. Leiomyoma was the most common pathology found in hysterectomy specimens in our study which is also true for other countries. Adenomyosis identified on histopathological examination was seen to be an important lesion in cases presenting with DUB. Hence, cases presenting with DUB should be thoroughly evaluated to rule out any underlying pathology.
To know the incidence of leiomyoma in hysterectomy specimens and study the degenerative changes of leiomyoma and its variants. A prospective study of 1000 hysterectomy specimens was done. All the chief complaints, gross features and microscopic findings were recorded. The most common benign lesion found was leiomyoma in 55.4% cases followed by adenomyosis in 32.5% cases. Majority of leiomyoma cases (99.2%) were usual leiomyoma. 2 variants of leiomyoma, 1 case of cellular leiomyoma and other case of mitotically active leiomyoma were found. Leiomyoma was the most common pathology found in hysterectomy specimens in our study which is also true for other countries. Adenomyosis identified on histopathological examination was seen to be an important lesion in cases presenting with DUB. Hence, cases presenting with DUB should be thoroughly evaluated to rule out any underlying pathology.
Leiomyomas are the most common benign tumors seen clinically in 20 -30 % of women over 30 years of age and are hormone responsive. These tumors are found at different locations in the uterus and present with different clinical symptoms. Various degenerative changes are common in them. Methods: This is a descriptive study conducted in the department of Pathology in NRI Institute of Medical Sciences, Sangivalasa to estimate the incidence of leiomyomas and associated degenerative changes along with pattern of endometrium and other associated pathologies of cervix and myometrium. Results: Out of 82 hysterectomy specimens, 48 cases showed Leiomyomas. Leiomyomas were most common in multiparous women in the 41-50 years age group. Menorrhagia was the most common symptom seen in 33(68.75%) cases followed by dysmenorrhea in 7(14.58%) cases. 28(58.33%) cases showed multiple broids and 20(41.66%) showed single broids. The most common location was intramural with 38(79.16%) cases.13 cases showed degenerative changes with the commonest degeneration being Hyaline degeneration in 8 (16.66%) cases. Cystic change was seen in 2 cases (4.16%), myxoid change in 2(4.16%) cases and calcareous change were seen in 1(2.08%) cases. The most common endometrial pattern was proliferative phase, seen in 24 cases (50%).The other uterine pathologies associated with leiomyoma were, chronic cervicitis in 30(62.5%) cases and adenomyosis, seen in 8(16.66%) cases. Conclusion: Leiomyomas are the most common benign tumors of the myometrium. Degenerative changes occurring in them cause diagnostic difculties which can only be conrmed histologically.
Introduction: Uterine smooth muscle tumors are the most common tumors of female genital tract and among these leiomyomas predominate. Leiomyomas most commonly occur during the reproductive years in women with manifestation of abnormal uterine bleeding and abdominal pain. These exhibit wide range of morphological variants and secondary changes. Here, we present a study of 70 cases, which includes rare variants and degenerative changes in leiomyomas. Materials and methods:A retrospective study conducted in a department of pathology for a period of 1 year from January 2019 to December 2019 at a tertiary care hospital. Seventy patients were diagnosed as leiomyoma on histopathological examination of 124 hysterectomy specimens and one myomectomy specimen and included in the study. Detailed microanatomic features were studied and recorded. Result: Uterine leiomyoma was most common among the age-group of 41-50 years of age (64.21%). Most common location was intramural (54.29%). Secondary changes were observed in 48 cases (68.57%). Most common secondary change was hyaline degeneration noted in 38 cases (79.17%). Classical variant of leiomyoma was seen in 66 cases (94.28%) followed by one case (1.43%) each of symplastic, neurilemmoma-like, lymphocyte-rich, and cellular leiomyoma and leiomyomas with rare secondary changes like osseous and chondroid metaplasia. Conclusion: Uterine smooth muscle tumors are commonly seen in perimenopausal females. Leiomyoma is associated with various pathologies comprising of degenerative changes and rare variants which sometimes can be misdiagnosed as malignancy. Hence, a vigilant histopathological examination is necessary to identify the various spectrum of uterine leiomyomas and associated pathologies.
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