To assess the familial aggregation of uterine myomas in Japanese women with myomas, one hundred forty four women requiring surgery for myomas and 288 age-matched healthy controls were studied in Hokkaido, Japan. The incidence of positive first-degree family history of myoma: among women aged 45-54 years with myomas was greater than that among controls (31.5 % versus 15.2%, respectively, p < 0.01). Analyses categorized by the status of parity and familialit) among subjects showed that the risk for myomas was the greatest in women who had both fewe births (parity = 0 or 1) and the positive family history of myomas as compared with those who hac both more births (parity ? 2) and the negative familiality of myomas (odds ratio = 5.8, 95% confidence interval = 2.3 -14.
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