Failure to isolate Helicobacter pylori from stray cats indicates that H. pylori in cats may be an anthroponosis - an animal infection with a human pathogen

El-Zaatari, F. A. K.; Woo, Jae-Soon; Badr, Adnan S; Osato, Michael S.; Serna, H.; Lichtenberger, Lenard M.; Genta, Robert M.; Graham, David Y.

doi:10.1099/00222615-46-5-372

Cited by 55 publications

(38 citation statements)

References 39 publications

(4 reference statements)

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“…Authors claimed that contact with sheep and sheepdogs was a risk factor for infection [16]. However, other authors failed to isolate H. pylori and/or to detect its antibodies due to natural infection from stray and pet cats [42,43] and pigs in abattoirs [44]. These questionable data suggest doubtful zoonotic transmission of such agent, and whether animals are true reservoir hosts for H. pylori or not is still not obvious.…”

Section: Discussionmentioning

confidence: 91%

“…These questionable data suggest doubtful zoonotic transmission of such agent, and whether animals are true reservoir hosts for H. pylori or not is still not obvious. It seems that infection might be contracted from a common source (e.g., drinking water, consumption of raw vegetables) or might suggest that H. pylori infection could be an anthroponosis (infections maintained mainly in humans that may be transmitted to animals) [42]. It was very difficult in this investigation to implicate or rule out infection of H. pylori to animal contact alone since combinations of other factors, including hygienic conditions, environmental factors, and socioeconomic status, contribute to the spread of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Serologic evidence and risk factors for Helicobacter pylori infection in animals and humans

Elhariri

Elhelw

Hamza

et al. 2017

J Infect Dev Ctries

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Introduction: Helicobacter pylori (H. pylori) is one of the most common bacterial infections among humans worldwide. Although many records imply its interfamilial acquisition, the role of animals remains poorly understood. This study was undertaken to investigate the seroprevalence of H. pylori in animals and their human contacts in Cairo and Giza governorates, Egypt. Methodology: Commercial enzyme-linked immunosorbent assay (ELISA) kits were used to detect IgG antibodies to H. pylori in dogs, cattle, and humans. Results: Seropositive dogs (35/94; 37.2%), cattle (24/80; 30%) and humans (40/90; 44.4%) were found. Seroprevalence in animals significantly varied in different areas of sample collection, but there was no association with sex or age. Human seropositivity rates were associated with increasing age; moreover, seropositive dog owners (51.7%; 15/29), had seropositive dogs. However, infection was not associated with subject's sex, occupation, or history of animal contact. Conclusions: Our findings indicate H. pylori is widely distributed in cattle and dogs and their human contacts in Cairo and Giza, Egypt. Further studies to determine infection in other occupational groups are needed. This study provides baseline information on the seroprevalence of H. pylori, which may be required to begin prevention control programs in our area.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Serologic evidence and risk factors for Helicobacter pylori infection in animals and humans

Elhariri

Elhelw

Hamza

et al. 2017

J Infect Dev Ctries

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“…H. pylori has been demonstrated by culture and PCR methods in the gastric mucosa of specific-pathogen-free laboratory cats in one study (90). This observation may be related to an anecdotic anthroponosis, especially since these bacteria have not been identified in stray cats (62).…”

Section: Non-h Pylori Helicobacter-associated Gastric Diseases In Humentioning

confidence: 99%

“…They are present in 67 to 86% of clinically healthy dogs and in 61 to 100% of dogs presenting chronic vomiting (105,112). In cats, spiral-shaped organisms have been detected in 41 to 100% of the animals investigated, with a slightly higher rate in animals presenting chronic vomiting (62,80,105,112,161,171,172,236,243). Bridgeford et al (23) hypothesized that gastric Helicobacter species may be a cause of feline gastric lymphoma.…”

Section: Gastric Helicobacters Associated With Dogs and Catsmentioning

confidence: 99%

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

et al. 2009

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SUMMARY Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. These very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated “H. heilmannii,” but in fact they comprise at least five different Helicobacter species, all of which are known to colonize the gastric mucosa of animals. H. suis, which has been isolated from the stomachs of pigs, is the most prevalent gastric non-H. pylori Helicobacter species in humans. Other gastric non-H. pylori helicobacters colonizing the human stomach are H. felis, H. salomonis, H. bizzozeronii, and the still-uncultivable “Candidatus Helicobacter heilmannii.” These microorganisms are often detected in the stomachs of dogs and cats. “Candidatus Helicobacter bovis” is highly prevalent in the abomasums of cattle but has only occasionally been detected in the stomachs of humans. There are clear indications that gastric non-H. pylori Helicobacter infections in humans originate from animals, and it is likely that transmission to humans occurs through direct contact. Little is known about the virulence factors of these microorganisms. The recent successes with in vitro isolation of non-H. pylori helicobacters from domestic animals open new perspectives for studying these microorganisms and their interactions with the host.

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“…Excluding cats with H. pylori infection, the gastric Helicobacter-like organisms (HLOs) in cats are morphologically indistinguishable by light microscopy, but have been classified into several Helicobacter spp. on the basis of cultural characteristics, 16S rRNA sequencing, DNA hybridization, PCR with species-specific primers, electron microscopic appearance, and protein profiling (9,15,34,36,49,51). To date, Helicobacter felis, H. heilmannii, Helicobacter pametensis, and H. felis-and H. heilmannii-like organisms have been identified (9,15,34,36,49,51).…”

mentioning

confidence: 99%

Helicobacter felisInfection Is Associated with Lymphoid Follicular Hyperplasia and Mild Gastritis but Normal Gastric Secretory Function in Cats

et al. 2000

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The relationship of Helicobacter felis, a bacterium observed in the stomachs of cats, to gastric disease is unclear. The objective of this study was to determine if H. felis infection alters gastric histopathology, proinflammatory cytokine expression, and secretory function and evokes a humoral immune response in cats. Five specific-pathogen-free (SPF) Helicobacter-free cats were studied before and for 1 year after oral inoculation with H. felis (ATCC 49179). Four SPF H. felis-uninfected cats served as controls. The stomachs of all five H. felis-inoculated cats became colonized, as determined by urease activity, histopathology, PCR, culture, and transmission electron microscopy of serial gastric biopsies at 0, 3, 5, 8, and 12 months. Uninoculated cats remained Helicobacter free. Lymphoid follicular hyperplasia, atrophy, and fibrosis were observed primarily in the pylorus of infected cats. Mild mononuclear inflammation was detected in both infected and uninfected cats, but was more extensive in infected cats, with pangastric inflammation, eosinophilic infiltrates, and cardia gastritis observed only in infected cats. No upregulation of antral mucosal interleukin 1␣ (IL-1␣), IL-1␤, or tumor necrosis factor alpha was detected by reverse transcription-PCR in any cat. The gastric secretory axes, assessed by fasting plasma gastrin, antral mucosal gastrin and somatostatin immunoreactivity, and pentagastrin-stimulated gastric acid secretion, were similar in both infected and uninfected cats. Gradual seroconversion (immunoglobulin G) was observed in four of five infected cats, with enzyme-linked immunosorbent assay values reaching 4؋ to 12؋ baseline 12 months postinfection. These findings indicate that H. felis infection in cats induces lymphoid follicular hyperplasia, mild gastritis, and seroconversion, but is associated with normal gastric secretory function.

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Failure to isolate Helicobacter pylori from stray cats indicates that H. pylori in cats may be an anthroponosis - an animal infection with a human pathogen

Cited by 55 publications

References 39 publications

Serologic evidence and risk factors for Helicobacter pylori infection in animals and humans

Serologic evidence and risk factors for Helicobacter pylori infection in animals and humans

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

Helicobacter felisInfection Is Associated with Lymphoid Follicular Hyperplasia and Mild Gastritis but Normal Gastric Secretory Function in Cats

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