Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

Abstract

SUMMARY Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. These very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated “H. heilmannii,” but in fact they comprise at least five different Helicobacter species, all of which are known to colonize the gastric mucosa of animals. H. suis, which has been isolated from the stomachs of pigs, is the most prevalent gastric non-H. pylori Helicobacter species in humans. Other gastric non-H. pylori helicobacters colonizing the human stomach are H. felis, H. salomonis, H. bizzozeronii, and the still-uncultivable “Candidatus Helicobacter heilmannii.” These microorganisms are often detected in the stomachs of dogs and cats. “Candidatus Helicobacter bovis” is highly prevalent in the abomasums of cattle but has only occasionally been detected in the stomachs of humans. There are clear indications that gastric non-H. pylori Helicobacter infections in humans originate from animals, and it is likely that transmission to humans occurs through direct contact. Little is known about the virulence factors of these microorganisms. The recent successes with in vitro isolation of non-H. pylori helicobacters from domestic animals open new perspectives for studying these microorganisms and their interactions with the host.

IDENTIFICAÇÃO DE Helicobacter spp. EM MUCOSAS GÁSTRICA E DUODENAL DE CÃES (Canis familiaris) UTILIZANDO A TÉCNICA DE WARTHIN-STARRY

“…Já em região de antro pilórico foi observado que 11,5% (3/26) das amostras apresentavam a bactéria. A existência de bactérias espiraladas na mucosa gástrica pode não estar correlacionada com doenças digestivas do animal (19,20) , podendo, entretanto, ser uma fonte de disseminação dessas bactérias. A falta de sinais clínicos e lesões macroscópicas evidentes em caninos infectados nos levam a crer que a bactéria não seja tão patogênica para esses como são para os felinos, em que as lesões se assemelham às observadas em humanos.…”

“…De acordo com Ülgen et al (22) , não há relação entre carga bacteriana, sintomas clínicos e presença de Helicobacter spp. na mucosa gástrica, o que dificulta a avaliação da relação helicobacteriose e gastrite, permanecendo incerto seu significado patogênico, provavelmente associado à dependência da relação cepa e hospedeiro (19) . Estudos apontam a presença de Helicobacter spp.…”

Helicobacteriose em leitões: imuno-histoquímica em amostras colhidas por meio de gastroscopia

“…Por outro lado, Park et al (2004), por meio de outras técnicas de diagnóstico, encontraram altas taxas de infecção do Helicobacter, especialmente na região do antro. Haesebrouck et al (2009) …”

Detection of gastric Helicobacter spp. in stool samples of dogs with gastritis

“…Helicobacter bacteria may colonize the gastrointestinal mucosa of humans, domestic animals (such as the dog, cat, pig, ferret and poultry) and wild animals (such as the cheetah or monkey) (Haesebrouck et al 2009, Casagrande Proietti et al 2010, Abdi et al 2014, Hong et al 2015. In human medicine, Helicobacter pylori has been confirmed as contributing to the development of chronic inflammation of the gastric mucosa as well as gastric and duodenal ulcers.…”