Failure of PTH, Calcitonin, or Vitamin D Metabolites to Influence Calcium Transport in the Maturation Stage Enamel Organ

Bawden, James; Deaton, T.G.; Timko, D.A.; Crenshaw, M.A.

doi:10.1177/00220345850640090801

Cited by 4 publications

(1 citation statement)

References 7 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Calcium release from the tooth germs was stimulated by PTH, but CT blocked the PTH effect. The effects of CT and PTH on calcium transport through different stages of the enamel organ have also been studied with use of developing rat molars (Bawden et al, 1983(Bawden et al, , 1985. In these studies, the net transport of calcium through the enamel organ remained unchanged, even after the molars were exposed to CT and PTH.…”

Section: Introductionmentioning

confidence: 99%

In vitro Effects of Calcitonin and/or Parathyroid Hormone on Odontogenesis of Mouse Embryonic Molars

et al. 1989

View full text Add to dashboard Cite

Mandibular first molars of mouse embryos were cultivated for examination of the effects of calcitonin (CT) and/or parathyroid hormone (PTH) on the odontogenesis of the molars, and for determination of whether and how CT, which is a PTH antagonist, has an influence on the effect of PTH on odontogenesis. On the second day, the inner enamel epithelium in the control group had already differentiated into pre-ameloblasts. Typical odontoblasts had secreted a layer of predentin. On the fourth day of culture, the pre-ameloblasts achieved terminal differentiation into secretory ameloblasts, and enamel and dentin had already been deposited. PTH (1 unit/mL) inhibited the odontogenesis of the cultured molars during the designated culture periods (two and four days), while CT (0.5 unit/mL) stimulated odontogenesis. On the second day, the development of the molars in the CT + PTH group showed an intermediate stage between the control and PTH-treated explants, but on day 4 it corresponded to that of the controls. Moreover, when the molars exposed to PTH for two days were untreated and treated with CT for an additional two days, the former produced a small quantity of enamel matrix, while the latter formed a large amount of the matrix. These histological findings were also supported by a morphometric analysis of the enamel matrix in the cultured molars. The present results suggest that CT stimulates, but PTH suppresses, the odontogenesis of the mouse embryonic molars, and that CT is an antagonist to the inhibitory effect of PTH on odontogenesis.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro Effects of Calcitonin and/or Parathyroid Hormone on Odontogenesis of Mouse Embryonic Molars

et al. 1989

View full text Add to dashboard Cite

show abstract

Effects of parathyroid hormone on odontogenesis of the mouse embryonic molar toothIn vitro

Sakakura

1987

Calcif Tissue Int

View full text Add to dashboard Cite

Mandibular first molars of 17-day-old mouse embryos were cultured in vitro to examine the histological effects of various concentrations of parathyroid hormone (PTH) on odontogenesis of the molars. PTH did not affect the cytodifferentiation of mesenchymal cells into preodontoblasts but inhibited that of preodontoblasts into odontoblasts. Consequently, the odontoblasts failed to undergo dentinogenesis. On the other hand, inner enamel epithelium achieved terminal cytodifferentiation into secretory ameloblasts and these cells partially formed enamel in spite of the absence of dentin. All treated molars showed the same histological disturbances and these effects were independent of PTH dose. The present study indicated that PTH had an influence on mesenchyme-derived cells, inhibiting both the differentiation of odontoblasts and the formation of predentin and dentin.

show abstract

Subcellular co-localization and co-variations of two vitamin D-dependent proteins in rat ameloblasts

Berdal

Hotton

Kamyab

et al. 1991

Archives of Oral Biology

View full text Add to dashboard Cite

Failure of PTH, Calcitonin, or Vitamin D Metabolites to Influence Calcium Transport in the Maturation Stage Enamel Organ

Cited by 4 publications

References 7 publications

In vitro Effects of Calcitonin and/or Parathyroid Hormone on Odontogenesis of Mouse Embryonic Molars

In vitro Effects of Calcitonin and/or Parathyroid Hormone on Odontogenesis of Mouse Embryonic Molars

Effects of parathyroid hormone on odontogenesis of the mouse embryonic molar toothIn vitro

Subcellular co-localization and co-variations of two vitamin D-dependent proteins in rat ameloblasts

Contact Info

Product

Resources

About