Factors influencing erythrocyte destruction in artificial organs

Blood flow and damage by the roller pumps during cardiopulmonary bypass

“…It is well established that CPB damages the blood (Mulholland et al, 2000;Yarbourgh et al, 1966) by subjecting it to non-physiological forces (Blackshear et al, 1965;Nevaril et al, 1968;Leverette et al, 1972;Williams, 1973;Bernstein et al, 1967;Bluestein and Mockros, 1969), therefore prolonging the patient's recovery. A great deal of research has been focused on reducing this damage.…”

Vibrational spectroscopy for probing molecular-level interactions in organic films mimicking biointerfaces

“…Adequate interactions at the interface are necessary between biomaterials replacing parts of living systems and living tissues [1,2]. A clear example is the area of tissue engineering [3], for cell growth and differentiation are essential for producing artificial organs [4][5][6][7][8] and implants [9][10][11][12][13][14][15][16][17][18][19]. In drug delivery systems, surface coatings may be required for some types of release [20][21][22][23][24].…”

Trilinolein improves erythrocyte deformability during cardiopulmonary bypass.

“…During extra corporeal circulation, the shape of RBCs is altered, their membrane becomes less pliable, and calcium ion is accumulated in RBCs [1,2]. These changes may cause a reduction of RBC deformability which disturbs normal microcirculation, leads to organ dysfunction and increases morbidity and mortality of patients [3][4][5][6][7].…”