Trilinolein improves erythrocyte deformability during cardiopulmonary bypass.

Sk, Tsai; Chan, Paul; Ty, Lee; Yung, JM; Hong, Chien Tai

doi:10.1111/j.1365-2125.1994.tb05714.x

Cited by 17 publications

(10 citation statements)

References 18 publications

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“…Even if a modest cholesterol-lowering effect exists, it is unlikely to influence the risk of ischemic stroke because only very high levels (eg, Ն7.2 to 8.0 mmol/L) of serum total cholesterol are associated with increased risk of ischemic stroke 22,23 and few subjects in our study had such high cholesterol levels. Finally, linoleic acid also reduces platelet aggregation 8 and enhances erythrocyte deformation, 10 both of which may contribute to improved circulation in small blood vessels and a reduced risk of lacunar infarction.…”

Section: Discussionmentioning

confidence: 99%

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Linoleic Acid, Other Fatty Acids, and the Risk of Stroke

Iso

Sato

Umemura

et al. 2002

Stroke

203

139

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Background and Purpose-The role of serum fatty acids as a risk factor for stroke and stroke subtypes is largely unknown. Methods-A prospective nested case-control study of Japanese 40 to 85 years of age was conducted through the use of frozen serum samples from 7450 participants in cardiovascular risk surveys collected from 1984 to 1989 for 1 community and 1989 to 1992 for the other 2 communities. By the end of 1998, we identified 197 incident strokes whose subtypes were confirmed by imaging studies. Three controls per case were selected by matching for sex, age, community, year of serum storage, and fasting status. Results-Compared with controls, total (nϭ197), hemorrhagic (nϭ75), and ischemic (nϭ122) strokes had similar proportions of n3 polyunsaturated fatty acids, lower proportions of linoleic and arachidonic acids, and higher proportions of saturated and monosaturated acids, determined by gas chromatography. The multivariate odds ratios associated with a 1-SD increase in linoleic acid (5%) after adjustment for hypertension, diabetes, serum total cholesterol, and other cardiovascular risk factors were 0.72 [95% confidence interval (CI), 0.59 to 0.89] for total stroke, 0.66 (95% CI, 0.49 to 0.88) for ischemic stroke, 0.63 (95% CI, 0.46 to 0.88) for lacunar infarction, and 0.81 (95% CI, 0.59 to 1.12) for hemorrhagic stroke. The respective odds ratios for saturated fatty acids (4%) were 1.13 (95% CI, 1.05 to 1.65), 1.35 (95% CI, 1.01 to 1.79), 1.44 (95% CI, 1.03 to 2.01), and 1.21 (95% CI, 0.82 to 1.80). Further adjustment for other fatty acids attenuated these relations, but the relation between linoleic acid and risk of ischemic stroke remained statistically significant. Conclusions-A higher intake of linoleic acid may protect against ischemic stroke, possibly through potential mechanisms of decreased blood pressure, reduced platelet aggregation, and enhanced deformability of erythrocyte cells. (Stroke.

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Section: Discussionmentioning

confidence: 99%

“…9,10 However, the effects of serum fatty acid composition on the risk of stroke have not been examined extensively.…”

mentioning

confidence: 99%

Linoleic Acid, Other Fatty Acids, and the Risk of Stroke

Iso

Sato

Umemura

et al. 2002

Stroke

203

139

View full text Add to dashboard Cite

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“…During the pilot ex periment, however, an intravenous injection of 10~5g/kg trilinolein could induce a sharp fall of BP, followed by the animal's death. A previous experiment has shown that 10-7 M trilinolein has optimum result in improving erythrocyte deformability [10].…”

Section: Discussionmentioning

confidence: 99%

“…A linoleate-rich triacylglycerol (trilinolein) was recently purified from Panax pseudoginseng, i.e., a medicinal herb widely used in traditional Chinese medi cine for treatment of circulatory disorders. This compound was found to improve the deformability of calcium-loaded erythrocyte and erythrocyte passing heart-lung machine during open heart surgery [9,10]. Previously, reduced erythrocyte deformability was impli cated as a contributing factor in disturbed microcirculation, and drugs which improved erythrocyte deformability were found to be beneficial for ischemic injury [11], Therefore, in this study, we examined whether trilinolein could effectively suppress arrhythmias in duced by coronary occlusion and reperfusion, and furthermore, whether trilinolein could re duce the infarct zone in animals subjected to coronary ligation.…”

Section: Introductionmentioning

confidence: 99%

Trilinolein Reduces Infarct Size and Suppresses Ventricular Arrhythmias in Rats Subjected to Coronary Ligation

et al. 1995

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Trilinolein, a triacylglycerol with linoleic acid as the only fatty acid residue in all esterified positions of glycerol, was previously found to improve erythrocyte deformability in vitro. In this study, the in vivo antiarrhythmic and anti-ischemic effects of trilinolein in coronary ligated rats were investigated. Male Sprague-Dawley rats were anesthetized with urethane. Trilinolein, at dosages ranging from 10–¹¹ to 10^–7 g/kg, was administered intravenously 15 min before ligation of coronary artery. Also, the effect of trilinolein on arrhythmia was studied by ligating the coronary artery for 30 min, then reperfusing myocardium for 10 min. During the 30-min ischemia, trilinolein reduced not only the number of ectopic beats but also the incidence rate and duration of ventricular tachycardia. At 10–⁷ g/kg, trilinolein completely suppressed all ventricular arrhythmias. Ventricular arrhythmias during 10 min reperfusion were also reduced by trilinolein at similar dosages. Furthermore, the effect of trilinolein on infarct size was evaluated by occluding the coronary artery for 4 h before the infarct zone was stained and weighed. In rats subjected to 4 h coronary ligation, pretreatment with 10–⁷ g/kg trilinolein at 15 min prior to the coronary ligation significantly reduced infarct size. Trilinolein may protect myocardium against ischemic injury and suppress arrhythmia during ischemia and reperfusion.

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“…In addition to an inhibitory effect on platelet aggregation, this compound improved the deformability of washed erythrocytes. Recently, it was also found to improve the deformability of erythrocytes in whole blood which had been subjected to cardiopulmonary bypass (Tsai et al, 1994). Two other triacylglycerols, namely triolein and tripalmitolein, improved erythrocyte deformability (Hong et al, 1993a).…”

Section: Discussionmentioning

confidence: 99%

Effect of trilinolein on cyclic nucleotide formation in human platelets: relationship with its antiplatelet effect and nitric oxide synthesis

Shen

Hong

1995

British J Pharmacology

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Trilinolein, a triacylglycerol with linoleic acid as the only fatty acid residue in all three esterified positions of glycerol, was recently reported to have an inhibitory effect on adrenaline‐induced platelet aggregation. In the present study, we found that trilinolein at concentrations ranging from 0.01 to 1 μM. increased cyclic GMP formation and decreased cyclic AMP formation in washed human platelets. Both NG‐nitro‐L‐arginine methyl ester (L‐NAME) and methylene blue attenuated the trilinolein‐induced increase in cyclic GMP. Adrenaline decreased not only the production of cyclic AMP but also that of cyclic GMP. Trilinolein antagonized the inhibitory effect of adrenaline on cyclic GMP formation, but potentiated the inhibitory effect of adrenaline on cyclic AMP accumulation. Both trilinolein and adrenaline enhanced intracellular calcium but the increment of intracellular calcium induced by them was much less than that produced by thrombin. We propose that the anti‐platelet effect of trilinolein is mediated through an increase in cyclic GMP, and that the change in cyclic GMP results from stimulation of nitric oxide synthesis in platelets. We also propose that reduction of both cyclic AMP and cyclic GMP are involved in adrenaline‐induced platelet aggregation.

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Trilinolein improves erythrocyte deformability during cardiopulmonary bypass.

Cited by 17 publications

References 18 publications

Linoleic Acid, Other Fatty Acids, and the Risk of Stroke

Linoleic Acid, Other Fatty Acids, and the Risk of Stroke

Trilinolein Reduces Infarct Size and Suppresses Ventricular Arrhythmias in Rats Subjected to Coronary Ligation

Effect of trilinolein on cyclic nucleotide formation in human platelets: relationship with its antiplatelet effect and nitric oxide synthesis

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