Factors influencing arthrodesis rates in a rabbit posterolateral spine model with iliac crest autograft

Ghodasra, Jason H.; Daley, Erika; Hsu, Erin L.; Hsu, Wellington K.

doi:10.1007/s00586-013-3074-0

Cited by 19 publications

(21 citation statements)

References 82 publications

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“…Можно считать доказанной положительную корреляцию между количеством аутотрансплантата и частотой состоявшегося спондилодеза [15]. По данным Ghodasra J. H. et al, объем аутотрансплантата, который может приводить к надежному сращению при костно-пластическом спондилодезе, составляет для одного животного 4 -5 см 3 костной ткани [5]. В классической модели экспериментального поясничного межпоперечного спондилодеза Boden S.D.…”

Section: таблицаunclassified

“…Продолжающаяся резорбция кортикальной порции трансплантата на 5-ой неделе после костной пластики, значительное увеличение объема костного мозга в сочетании с уменьшением содержания минерализованной кости в центре спондилодезных масс с 6-ой недели [3] может сопровождаться участками рентгеннегативного изображения костного артродеза и приводить к ложноотрицательному снижению частоты состоявшегося спондилодеза. Оптимальные сроки оценки результатов спондилодеза зависят от ряда факторов, включающих, в частности, цели исследования, объем трансплантата, остеиндуктивные [5] и остеокондуктивные [23; 24] возможности экстендора (заменителя) костного трансплантата. При использовании костных аутотрансплантатов идеальное время для оценки экспериментального поясничного межпоперечного спондилодеза у кролей -не менее 5 нед.…”

Section: таблицаunclassified

“…При использовании костных аутотрансплантатов идеальное время для оценки экспериментального поясничного межпоперечного спондилодеза у кролей -не менее 5 нед. после операции [5,7], а в случае применения экстендоров костных трансплантатов продолжительность эксперимента увеличивается, превышая 5 -6 нед. [3,[25][26][27][28].…”

Section: таблицаunclassified

“…Частота состоявшегося спондилодеза с использованием аутотрансплантата из гребня подвздошной кости в данной модели и в клинике имела сходные показатели. В настоящее время модель на кроликах является наиболее широко используемой доклинической моделью для поясничного спондилодеза [5].…”

Section: Introductionunclassified

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Criteria for choosing the optimal parameters of animal model of lumbar intertransverse fusion in rabbits

Radchenko¹,

Palkin²,

Kolesnichenko³

2017

Morphologia

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ГУ «Институт патологии позвоночника и суставов имени профессора М.И. Ситенко НАМН Украины», Харьков Ключевые слова: поясничный межпоперечный спондилодез, костный аутотрансплантат, экспериментальная модель, кроли, мета-анализ.

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Section: таблицаunclassified

Section: Introductionunclassified

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Criteria for choosing the optimal parameters of animal model of lumbar intertransverse fusion in rabbits

Radchenko¹,

Palkin²,

Kolesnichenko³

2017

Morphologia

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“…After blood, bone grafts are the second most common transplants (Candas 1983). Autogenous bone grafts are the most popular among bone graft materials because they are bio-compatible, osteo-conductive, and cost-effective (Ghodasra et al 2014). Autografts reduce the risk of infectious disease transmission, and they exhibit optimal osteo-conductive, osteoinductive, and osteogenic properties (Shafiei et al 2009).…”

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confidence: 99%

Cuttlebone used as a bone xenograft in bone healing

Doğan¹,

Okumuş²

2014

Vet. Med.

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This study was conducted to examine the potential of cuttlebone xenograft in the healing of bone using radiography and histology for a period of 24 weeks. One hundred and five New Zealand male rabbits with radius defects in the metaphyseal region were divided into five groups treated with cuttlebone, demineralized bone matrix, bovine cancellous graft, and tricalcium phosphate. The control was no treatment. Clinical, radiological, biochemical and histological evaluations were made 1, 2, 3, 4, 6, 12, and 24 weeks after surgery. Physiological measurements (body temperature, heart rate, and respiratory rate) were not affected by the treatments. The radiological score was greatest in the demineralised bone matrix and tricalcium phosphate groups (score of 8), followed by the bovine cancellous graft (score of 6), cuttlebone (score of 6), and control groups (score of 5). The histological score was greatest in the tricalcium phosphate group (score of 55), followed by the cuttlebone (score of 50), bovine cancellous graft (score of 48), demineralized bone matrix (score of 44) and control groups (score of 42). Oxidative enzyme activities were not different across the treatments. The lack of reinfection and infection responses and faster bone union highlight the potential of cuttlebone xenograft in orthopaedic surgery.

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Efficacy of a synthetic calcium phosphate with submicron surface topography as autograft extender in lapine posterolateral spinal fusion

Dijk

Barbieri²,

Groot³

et al. 2019

J Biomed Mater Res

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Posterolateral spinal fusion (PLF) is a common procedure in orthopedic surgery that is performed to fuse adjacent vertebrae to reduce symptoms related to spinal conditions. In the current study, a novel synthetic calcium phosphate with submicron surface topography was evaluated as an autograft extender in a validated rabbit model of PLF. Fifty‐nine skeletally mature New Zealand white rabbits were divided into three groups and underwent single‐level intertransverse process PLF at L4‐5 using (1) autologous bone graft (ABG) alone or in a 1:1 combination with (2) calcium phosphate granules (ABG/BCP granules ), or (3) granules embedded in a fast‐resorbing polymeric carrier (ABG/BCP putty ). After 6, 9, and 12 weeks, animals were sacrificed and spinal fusion was assessed by manual palpation, Radiographs, micro‐CT, mechanical testing (12 weeks only), histology, and histomorphometry. Based on all endpoints, all groups showed a gradual progression in bone formation and maturation during time, leading to solid fusion masses between the transverse processes after 12 weeks. Fusion assessments by manual palpation, radiography and histology were consistent and demonstrated equivalent fusion rates between groups, with high bilateral fusion rates after 12 weeks. Mechanical tests after 12 weeks indicated substantially lower range of motion for all groups, compared to non‐operated controls. By histology and histomorphometry, the gradual formation and maturation of bone in the fusion mass was confirmed for each graft type. With these results, we describe the equivalent performance between autograft and a novel calcium phosphate material as an autograft extender in a rabbit model of PLF using an extensive range of evaluation techniques. © 2019 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2080–2090, 2019.

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Factors influencing arthrodesis rates in a rabbit posterolateral spine model with iliac crest autograft

Cited by 19 publications

References 82 publications

Criteria for choosing the optimal parameters of animal model of lumbar intertransverse fusion in rabbits

Criteria for choosing the optimal parameters of animal model of lumbar intertransverse fusion in rabbits

Cuttlebone used as a bone xenograft in bone healing

Efficacy of a synthetic calcium phosphate with submicron surface topography as autograft extender in lapine posterolateral spinal fusion

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