Factors associated with surgery in patients with renal cell carcinoma and venous tumor thrombus

Abstract

• Univariable and multivariable logistic regression analysis was performed to identify factors associated with surgery. RESULTS• We identified 24 396 patients with RCC, of which 2265 (9.3%) had venous tumour thrombus.• CONCLUSIONS• In this population-based study, over 80% of patients with RCC and venous tumour thrombus underwent surgical management.• Although age and TNM stage were strongly associated with the decision to undergo surgery, marital status was also associated with treatment choice.• It is unclear whether marital status affects oncological outcomes or complication rates so the reasons behind this association deserve further investigation.

Cytoreductive nephrectomy with thrombectomy before targeted therapy improves survival for metastatic renal cell carcinoma with venous tumor thrombus: a single-center experience

“…Pierorazio PM has already shown that patients with widespread metastatic burden may not benefit from surgery and are likely to choose conservative management [26]. A population-based study based on the surveillance, epidemiology, and end results database revealed a similar result [27]. Some patients even failed to receive targeted therapy after surgery for various reasons.…”

Cytoreductive nephrectomy for metastatic renal cell carcinoma in the era of targeted therapy in the United States: a SEER analysis

“…Martial status was also shown to be independently associated with undergoing CyNx in the current analysis, with married patients 59 % more likely to undergo surgery. Marital status has been regarded as an important surrogate for social support [15], and previous studies have also described an association between marital status and the likelihood of undergoing CyNx [16, 17]. …”

Nephrectomy, inferior vena cava thrombectomy in renal cell carcinoma with tumor venous thrombosis and pulmonary metastases

“…Тем не менее отношение к паллиативной нефрэктомии, тромбэктомии (пНЭТЭ) остается сдержанным. В настоящее время около 80 % больных диссеминированным раком почки с опухолевым венозным тромбозом получают только консервативное лечение [8,9], ассоциированное с неудовлетворительными результатами. Медиана выживаемости неоперированных пациентов с опухолевым венозным тромбозом колеблется от 3,5 до 5,0 мес, и более 70 % пациентов умирают от прогрессирования в течение 1 года [8].…”