Factors associated with preoperative and postoperative epileptic seizure in patients with cerebral ganglioglioma

Huang, Cheng; Li, He; Chen, Mingwan; Yang, Shuanying; Lei, Ding

doi:10.12669/pjms.302.4362

Cited by 13 publications

(9 citation statements)

References 18 publications

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“…Previous studies have showed that abnormal cranial imaging findings were associated with increased seizures frequency. 14 , 15 In our study, the presence of FC was associated with temporal changes in seizure frequency in all epilepsy patients. A previous study of surgical and nonsurgical treatment found that FC had no effect on seizure frequency.…”

Section: Discussionsupporting

confidence: 55%

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The long-term prognosis of epilepsy patients with medically treated over a period of eight years in Turkey

2017

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Objective:The aim of this study was to investigate the effect of demographic and clinical characteristics on temporal changes in seizure control and frequency in medically treated epilepsy patients to guide treatment modalities.Methods:We retrospectively analyzed the association between clinical and demographic characteristics and seizure frequency in 1329 epilepsy patients who were followed up at an outpatient clinic for one to eight years, 2008-2015..Results:Younger age at first seizure (p = 0.0465) and a long disease duration (p = 0.0406) had a negative effect on seizure control in all the epilepsy patients. Febrile convulsions (FCs) (p > 0.0001), perinatal risk (PNR) (p > 0.0002), a family history of epilepsy (FHE) (p > 0.0016), antiepileptic drug (AED) use (p > 0.001), mental retardation (MR) (p > 0.001), and psychiatric disorders (p > 0.0478) were prognostic indictors of temporal changes in seizure frequency. The presence of PNR (p = 0.0416), age at onset of epilepsy (p = 0.034), central nervous system infection (CNSI) (p = 0.04), and AEDs number (p = 0.0282) were prognostic indicators of not remaining seizure free for one year. In those with partial epilepsy, a trauma history (p = 0.05), a longer epilepsy duration (p = 0.0057), and FHE (p = 0.0466) increased the frequency of seizures, whereas cerebrovascular event (CVE) history decreased the seizure frequency (p = 0.0413). In addition, FHE (p = 0.0438) and psychotic disorders (p = 0.0416) increased generalized seizures frequency.Conclusion:In all the epilepsy patients, a younger age at onset and longer duration of epilepsy were associated with a poor prognosis. The presence of PNR, age at onset of epilepsy, CNSI, and AEDs numbers were prognostic indicators of not remaining seizure free for one year. Increasing AEDs number was not effective in controlling seizures in partial epilepsy, but it was effective in controlling seizures in generalized epilepsy.

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Section: Discussionsupporting

confidence: 55%

“…Some studies conducted in developed countries finding no relation between PNR and the prognosis in epilepsy patients and others conducted in developing countries finding that PNR was a poor prognostic indicator. 14 , 15 …”

Section: Discussionmentioning

confidence: 99%

The long-term prognosis of epilepsy patients with medically treated over a period of eight years in Turkey

2017

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“…Seizures are the common manifestations of GGs, and despite low incidence, GG comprises approximately 40% of long-term tumor-associated epilepsy ( 10 , 16 ). It has been demonstrated that GGs primarily occur in children and young adults and more commonly involve the temporal lobe ( 3 , 20 – 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…Studies focusing on patients with GG have identified some factors associated with favorable seizure outcomes, such as age at surgery, duration of epilepsy, completeness of tumor, etc. ( 8 , 10 , 13 , 26 – 28 ). In this clinical cohort study, the duration of seizures > two years was a potential factor associated with unfavorable seizure outcomes.…”

Section: Discussionmentioning

confidence: 99%

Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy

Zhang

Adilijiang

et al. 2022

Front. Surg.

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IntroductionGanglioglioma (GG) patients often present with seizures. Although most patients can be seizure-free after tumor resection, some still experience seizures. The present study aimed to analyze a group of GGs patients associated with epilepsy and evaluate the seizure outcomes and prognostic factors.MethodsThis retrospective study involved clinical data collected from medical records of patients diagnosed with GG pathologically and underwent surgical resection in Sanbo Brain Hospital, Capital Medical University. The seizure outcomes were evaluated based on the International League Against Epilepsy (ILAE) seizure outcome classification. The prognostic factors were identified according to univariate and multivariate analysis.ResultsA total of 222 patients were included, with a mean age at surgery of 19.19 ± 10.93 years. All patients were followed up at least for one year with a mean follow-up duration of 6.28 ± 3.17 years. At the final follow-up, 174 (78.4%) patients achieved ILAE Class 1 or 2. Univariate and multivariate analyses revealed that the short duration of seizures and gross total resection were significant positive factors for seizure-free. Bilateral interictal or ictal epileptiform discharges in preoperative video-electroencephalogram (VEEG) were related to poor seizure outcomes.ConclusionSurgical resection is an effective treatment for patients with epilepsy associated with GGs. The analysis of predictive factors could effectively guide clinical practice and evaluate the prognosis of epilepsy with GG.

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“…The incidence ranged from 34.8% to 72.0% (mean: 68.2%; 95% CI: 62.4%-73.8%) for insula lobe gliomas, compared to 34.3% to 81.3% (mean: 66.0%; 95% CI: 63.1%-68.8%) for gliomas without insula lobe involvement. Overall (I-squared = 46.8%, p = 0.037) Wang Y et al, 2015Yuen TI et al, 2012(prospective) Huang L et al, 2011Huang C et al, 2014Yang P et al, 2014Liubinas SV et al, 2014Yuen TI et al, 2012(retrospective) You G et al, 2012Chang EF et al, 2008Stockhammer F et al, 2012Lee JW et al, 2010Iuchi T et al, 2015 Study A Figure 3. Temporal lobe gliomas and preoperative seizure incidence.…”

Section: Relationship Between Tumour Location and Preoperative Seizurmentioning

confidence: 99%

Relationship between tumour location and preoperative seizure incidence in patients with gliomas: a systematic review and meta‐analysis

Su¹,

Chen

Wang³

et al. 2015

Epileptic Disorders

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Aim. The aim of this meta‐analysis was to assess the relationship between tumour location and preoperative seizure incidence in patients with gliomas. Methods. Systematic computerised searches of PubMed and the Web of Knowledge were performed. The meta‐analysis of pooled odds ratio (OR) and 95% confidence interval (CI) for preoperative seizure risk, stratified by tumour location, were calculated. Results. Eleven studies with 2,047 patients were included for meta‐analysis. For gliomas with or without frontal lobe involvement, the preoperative seizure incidence ranged from 31.7% (19/60) to 85.7% (156/182) and 19.7% (12/61) to 85.7% (12/14), respectively; the pooled OR was 1.560 (95% CI: 1.266–1.923; Z: 4.17; p=0.000). For gliomas with or without temporal lobe involvement, seizure incidence was 22.6% (7/31) to 91.7% (11/12) and 26.7% (24/90) to 78.7% (174/221), respectively; the pooled OR was 1.070 (95% CI: 0.794–1.443; Z: 0.45; p=0.656). For gliomas with or without parietal lobe involvement, seizure incidence was 18.1% (3/16) to 100.0% (3/3) and 26.7% (28/105) to 80.4% (226/281), respectively; the pooled OR was 0.770 (95% CI: 0.570–1.040; Z: 1.71; p=0.088). For gliomas with or without occipital lobe involvement, seizure incidence was 0.0% (0/2) to 100.0% (2/2) and 26.8% (30/112) to 75.7% (56/74), respectively; the pooled OR was 0.336 (95% CI: 0.164–0.686; Z: 2.99; p=0.003). For gliomas with or without insula lobe involvement, seizure incidence was 34.8% (8/23) to 72.0% (77/107) and 34.3% (60/175) to 81.3% (247/304), respectively; the pooled OR was 1.058 (95% CI: 0.765–1.463; Z: 0.34; p=0.732). No significant publication bias was found. Conclusion. Our meta‐analysis indicates that frontal lobe gliomas are related to a higher preoperative seizure incidence, while occipital lobe gliomas are related to a lower incidence.

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Factors associated with preoperative and postoperative epileptic seizure in patients with cerebral ganglioglioma

Cited by 13 publications

References 18 publications

The long-term prognosis of epilepsy patients with medically treated over a period of eight years in Turkey

The long-term prognosis of epilepsy patients with medically treated over a period of eight years in Turkey

Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy

Relationship between tumour location and preoperative seizure incidence in patients with gliomas: a systematic review and meta‐analysis

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