Relationship between tumour location and preoperative seizure incidence in patients with gliomas: a systematic review and meta‐analysis

Abstract

Aim. The aim of this meta‐analysis was to assess the relationship between tumour location and preoperative seizure incidence in patients with gliomas. Methods. Systematic computerised searches of PubMed and the Web of Knowledge were performed. The meta‐analysis of pooled odds ratio (OR) and 95% confidence interval (CI) for preoperative seizure risk, stratified by tumour location, were calculated. Results. Eleven studies with 2,047 patients were included for meta‐analysis. For gliomas with or without frontal lobe involvement, the preoperative seizure incidence ranged from 31.7% (19/60) to 85.7% (156/182) and 19.7% (12/61) to 85.7% (12/14), respectively; the pooled OR was 1.560 (95% CI: 1.266–1.923; Z: 4.17; p=0.000). For gliomas with or without temporal lobe involvement, seizure incidence was 22.6% (7/31) to 91.7% (11/12) and 26.7% (24/90) to 78.7% (174/221), respectively; the pooled OR was 1.070 (95% CI: 0.794–1.443; Z: 0.45; p=0.656). For gliomas with or without parietal lobe involvement, seizure incidence was 18.1% (3/16) to 100.0% (3/3) and 26.7% (28/105) to 80.4% (226/281), respectively; the pooled OR was 0.770 (95% CI: 0.570–1.040; Z: 1.71; p=0.088). For gliomas with or without occipital lobe involvement, seizure incidence was 0.0% (0/2) to 100.0% (2/2) and 26.8% (30/112) to 75.7% (56/74), respectively; the pooled OR was 0.336 (95% CI: 0.164–0.686; Z: 2.99; p=0.003). For gliomas with or without insula lobe involvement, seizure incidence was 34.8% (8/23) to 72.0% (77/107) and 34.3% (60/175) to 81.3% (247/304), respectively; the pooled OR was 1.058 (95% CI: 0.765–1.463; Z: 0.34; p=0.732). No significant publication bias was found. Conclusion. Our meta‐analysis indicates that frontal lobe gliomas are related to a higher preoperative seizure incidence, while occipital lobe gliomas are related to a lower incidence.

Sex Differences in Predictors of Seizure in Contrast-Enhancing Gliomas at Clinical Presentation: A Network Approach

“…The frequency of seizure as an initial symptom of glioma varies across studies and tumor grade. Overall 43% in our cohort were SP well within the range (32% to 86%) reported in the systematic review by Su of all glioma grades 25 . As in our cohort (all six Grade II were SP) others report a greater prevalence of SP in LGG 20,21,23,26 .…”

“…Tumor location matters in SP, but the methods used to ascertain tumor location strongly vary across groups making comparisons and conclusions difficult. Many 22,25,28,29 studies reported highest incidences for frontal lobe tumors are associated with SP in both univariate and multivariate analyses. While Lee found temporal lobe tumors in LGG were twice as likely for SP but not true in HGG 24 .…”

Tumor-Related Epilepsy and Post-Surgical Outcomes: Tertiary Hospital Experience in Vietnam

“…2,3 High-grade gliomas also produce seizure symptoms, however, seizure rate is commonly less frequent compared to low-grade lesions. [4][5][6] Other low-grade tumors, such as gangliogliomas and dysembryoplastic neuroepithelial tumors (DNETs), are also reported to commonly cause seizures. 7 This could be explained by several mechanisms, in which molecular genetics play an important role.…”

Mir-338-3p Inhibits Malignant Biological Behaviors of Glioma Cells by Targeting MACC1 Gene

“…It is widely accepted that glioma cells possess a powerful proliferation ability, low apoptosis rate, and vigorous resistance to chemotherapy and radiotherapy, which contribute to malignancy and recurrence of glioma [ 10 – 12 ].…”