Factors associated with mortality in acute renal failure (ARF) in children

Munárriz, Reyner Loza; Estremadoyro, Luis; Loza, César; Cieza, Javier

doi:10.1007/s00467-005-2038-y

Cited by 32 publications

(35 citation statements)

References 9 publications

(11 reference statements)

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“…In developing countries, however, acute gastroenteritis and acute glomerulonephritis are more frequent causes of AKI, compared to developed countries [2,21,[23][24][25]. The etiology of AKI in our series was similar to that reported in recent series from developed countries.…”

Section: Discussionsupporting

confidence: 77%

“…Due to dissimilarities in the definition of AKI, study populations (i.e. special groups such as patients in intensive care units) and age groups of AKI, recent data on the epidemiology of AKI from different centers and countries are not easy to compare [2][3][4][5][21][22][23][24][25]. However, our literature search revealed certain features: (1) underlying causes vary between developed and developing countries;…”

Section: Discussionmentioning

confidence: 90%

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Etiology and outcome of acute kidney injury in children

et al. 2010

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The aim of this prospective, multicenter study was to define the etiology and clinical features of acute kidney injury (AKI) in a pediatric patient cohort and to determine prognostic factors. Pediatric-modified RIFLE (pRIFLE) criteria were used to classify AKI. The patient cohort comprised 472 pediatric patients (264 males, 208 females), of whom 32.6% were newborns (median age 3 days, range 1-24 days), and 67.4% were children aged >1 month (median 2.99 years, range 1 month-18 years). The most common medical conditions were prematurity (42.2%) and congenital heart disease (CHD, 11.7%) in newborns, and malignancy (12.9%) and CHD (12.3%) in children aged >1 month. Hypoxic/ischemic injury and sepsis were the leading causes of AKI in both age groups. Dialysis was performed in 30.3% of newborns and 33.6% of children aged >1 month. Mortality was higher in the newborns (42.6 vs. 27.9%; p < 0.005). Stepwise multiple regression analysis revealed the major independent risk factors to be mechanical ventilation [relative risk (RR) 17.31, 95% confidence interval (95% CI) 4.88-61.42], hypervolemia (RR 12.90, 95% CI 1.97-84.37), CHD (RR 9.85, 95% CI 2.08-46.60), and metabolic acidosis (RR 7.64, 95% CI 2.90-20.15) in newborns and mechanical ventilation (RR 8.73, 95% CI 3.95-19.29), hypoxia (RR 5.35, 95% CI 2.26-12.67), and intrinsic AKI (RR 4.91, 95% CI 2.04-11.78) in children aged >1 month.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 90%

Etiology and outcome of acute kidney injury in children

et al. 2010

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“…Flynn et al reported postoperative sepsis as a prominent cause of AKF in the paediatric population 14 . Several other studies also have reported sepsis as the major cause of AKF in children 7,13,15,16 . However, in developed countries cardiovascular surgeries and the haemolytic uremic syndrome (HUS) are the most important risk factors associated with AKF in the paediatric population 9,10 .…”

Section: Resultsmentioning

confidence: 99%

Aetiology and Outcome of Acute Kidney Failure In Bangladeshi Children Dhaka Medical College Hospital Experience

et al. 2016

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“…Çeşitli çalışmalarda mortalite açısından risk faktörleri olarak küçük ya da ileri yaş, eşlik eden böbrek dışı hastalık, sepsis, septik şok, multiorgan yetmezliği, hastanede yatış süresi, oligüri ve/veya anüri, hipotansiyon, ilaç kullanımı, mekanik ventilasyon, diyaliz, sıvı yüklenmesi, kardiyak cerrahi, prematürite, metabolik asidoz ve hiperkalemi olarak gösterilmektedir (4,6,7,9,(27)(28)(29)(30).…”

Section: Discussionunclassified

Acute Kidney Injury: Classification and Prognosis

Şen¹,

Çakar²

2017

Turkish J Pediatr Dis

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ÖZETAmaç: Çalışma ile çocuk hastalarda Akut Böbrek Hasarının (ABH) etiyolojisi, klinik özellikleri, prognoz üzerinde etkili faktörleri ve sonuçları tanımlamak için Acute Kidney Injury Network tarafından öne sürülen sınıflandırma kriterlerinin kullanılması ve ABH sınıflandırılmasında pediatrik-modifiye RIFLE (pRIFLE) kriterlerinin rutine geçirilmesi amaçlanmıştır. Gereç ve Yöntemler:Mayıs 2008-Temmuz 2010 arasında ABH tanısı ile yatırılan ya da hastanede izlemi sırasında ABH gelişen %25'i yenidoğan 72 hasta (42 erkek, 30 kız) ileri doğru olarak incelendi. Bulgular:Hastaların ortanca yaşı 9.11 ay (minimum 0, maksimum 216.56 ay)'dı. ABH nedeni olarak dehidratasyon, %30.6 oranı ile en sık etiyolojik faktör olarak saptandı. Bunu sırasıyla hipoksi (%19.4), sepsis (%16.7), ilaç (%12.5) ve hemolitik üremik sendroma (%9.7) bağlı ABH izledi. Hastaların %15.3'ü risk, %25'i hasar, %59.7'si ise yetmezlik olarak sınıflandırıldı. Mortalite oranı %26.4'dü. Erkek cinsiyet, mekanik ventilasyon, nefrotoksik ilaç, ABH gelişimi sırasında hastanede yatıyor olmak, oligüri/anüri ve nefroloji konsültasyonunun gecikmesi mortalite ile ilişkili bulundu (p<0.05). Mortalite oranı risk grubunda %10.7, hasar grubunda %31.5 ve yetmezlik grubunda %57.8'di. ABSTrAcTObjective: The aim of this study was to use the classification criteria suggested by the Acute Kidney Injury Network in order to define the etiology, clinical features, prognostic factors and results of Acute Kidney Injury (AKI) in pediatric patients and to support the routine application of pediatric-modified RIFLE (pRIFLE) criteria for the classification of AKI. Material and Methods:The patient group comprised 72 patients (42 males, 30 females) of whom 25% were newborns and 75% were children aged >1 month, who were either hospitalized due to a diagnosis of AKI or in whom AKI had developed during hospitalization between May 2008 and July 2010. results:The median age at the time of AKI was 9.11 months (minimum 0, maximum 216.56 months). The etiology of AKI was dehydration in 30.6%, hypoxia in 19.4%, sepsis in 16.7%, drug-induced in 12.5% and hemolytic uremic syndrome in 9.7%. AKI patients were classified according to the staging system as follows: 15.3% of the patients were in the risk, 25% in the injury, and 59.7% in the failure category. The mortality rate was 26.4%. Male sex, mechanical ventilation, nephrotoxic drugs, hospitalization before the development of AKI, oliguria/anuria and delay in nephrology consultation were found to be associated with increased mortality (p<0.05). Mortality rate was 10.7% for the risk, 31.5% for the injury and 57.8 % for the failure categories. conclusion:The pRIFLE classification was an effective method in predicting the need for dialysis and hospital mortality.

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Factors associated with mortality in acute renal failure (ARF) in children

Abstract: Oliguria, age, and sepsis are factors associated with mortality in children with ARF.

Cited by 32 publications

References 9 publications

Etiology and outcome of acute kidney injury in children

Etiology and outcome of acute kidney injury in children

Aetiology and Outcome of Acute Kidney Failure In Bangladeshi Children Dhaka Medical College Hospital Experience

Acute Kidney Injury: Classification and Prognosis

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Factors associated with mortality in acute renal failure (ARF) in children

Abstract: Oliguria, age, and sepsis are factors associated with mortality in children with ARF.

Cited by 32 publications

References 9 publications

Etiology and outcome of acute kidney injury in children

Etiology and outcome of acute kidney injury in children

Aetiology and Outcome of Acute Kidney Failure In Bangladeshi Children  Dhaka Medical College Hospital Experience

Acute Kidney Injury: Classification and Prognosis

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Resources

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Aetiology and Outcome of Acute Kidney Failure In Bangladeshi Children Dhaka Medical College Hospital Experience