Factors associated with microbiological and clinical cure of mastitis in dairy cows

Molina, L. R.; Neto, H.C. Diniz; Branco, R.S.P.C.; Lage, C.F.A.; Malacco, Victor Marco Rocha; Souza, Fernando Nogueira de; Diniz, S.A.; Gomes, Gabriella; Silva, M.X.

doi:10.1590/1678-4162-9995

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Also, in the present study, a cure rate was assessed based on three samples from all treated MQs up to 28 days after treatment, to minimize the number of false-negative results. Furthermore, MQ was considered cured with only three negative results for S. aureus after treatment, whereas other studies considered that two negative results for S. aureus after treatment (21 and 28 days after treatment) was sufficient for considering the MQ as cured (Sears et al 1990, Molina et al 2018.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of antimicrobial therapy in association with vaccination on the bacteriological cure of subclinical mastitis caused by Staphylococcus aureus in lactating cows

et al. 2022

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The objective of this study was to evaluate the efficacy of the antibiotic therapy associated with vaccination on the microbiological cure rate of subclinical mastitis caused by Staphylococcus aureus in lactating dairy cows. A total of five herds, from which 72 cows (120 mammary quarters - MQ) were diagnosed with S. aureus subclinical mastitis, were included in this study. Cows were randomly allocated to one of three treatment groups: a) Control (no treatment); b) ATB (antibiotic therapy); and c) ATB+VAC (antibiotic therapy plus vaccination against S. aureus). Intramammary treatment consisted of twice-daily infusion of ampicillin 75mg + cloxacillin 200mg, for 5 days. Parenteral treatment was done by injection of a single dose (7.5mg/kg) of enrofloxacin, on the first day of the treatment protocol. Vaccinated cows received three doses of a commercial vaccine 14 days before treatment (d-14), on the first day of treatment protocol (d1), and 14 days after the treatment protocol (d+14). Non-treated cows had a lower cure rate (0.06) than cows treated with ATB (0.84) and ATB+VAC (0.85). No difference in cure rate was observed between cows treated with ATB and ATB+VAC. On the other hand, vaccinated cows had lower somatic cell count (SCC) after 28 days of the treatment protocols (4.76 log10) than non-treated cows (5.37 log10). In conclusion, treatment with intramammary ampicillin and cloxacillin, associated with intramuscular enrofloxacin presented a high cure rate for SCM caused by S. aureus during lactation. The use of vaccination against S. aureus in association with antibiotic therapy did not increase the cure rate of MQ during lactation, but it was effective in reducing the SCC when compared to non-treated MQ. Although to ensure that the decrease of the SCC in ATB+VAC group was associated with the vaccination, the study should have included an additional group of only vaccinated cows, without antimicrobial therapy, with was not done in the present study, and therefore is one of the limitations of the experimental protocol used.

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Section: Discussionmentioning

confidence: 99%

Efficacy of antimicrobial therapy in association with vaccination on the bacteriological cure of subclinical mastitis caused by Staphylococcus aureus in lactating cows

et al. 2022

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“…Inst. Laticínios Cândido Tostes, Juiz de Fora, v. 78, n. 1, p. 22-32, jan/mar, 2023 duas culturas microbiológicas realizadas com 14 e 21 dias, porém nas propriedades essa avaliação é inviável (MOLINA et al, 2018;SANTOS;FONSECA, 2019).…”

Section: Tratamento De Mastite Clínicaunclassified

“…Quando não há cultura microbiológica do leite, a escolha do tratamento deve seguir com avaliação das características do animal para avaliar a necessidade do uso de antibiótico e o histórico de patógenos que estão presente no rebanho. Para esse caso é recomendado tratar com antibiótico intramamário por curto período de 3 a 4 dias (MOLINA et al, 2018;SANTOS;FONSECA, 2019).…”

Section: Tratamento De Mastite Clínicaunclassified

Influência da mastite sobre a produção e a qualidade do leite cru

Valente,

Silva

2023

Revista do ILCT

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O leite é um produto perecível e sua qualidade deve ser avaliada desde a propriedade até o lacticínio. A legislação impõe que os principais parâmetros para atestar a qualidade do leite são: medição da temperatura; teores de gordura, proteína, sólidos totais e não gordurosos; determinações do índice crioscópico, da densidade relativa a 15°C e da acidez titulável; pesquisa de resíduos de antibióticos; contagem padrão em placa (CPP); e contagem de células somáticas (CCS). Um dos maiores problemas enfrentados na bovinocultura leiteira é a mastite, que consiste na inflamação da glândula mamária, principalmente devido à contaminação bacteriana. Essa patologia causa um grande impacto econômico para os produtores de leite, pois altera a composição do leite e pode levar ao descarte do leite, diminui a produção animal, gera gastos com tratamento e pode resultar no descarte do animal. Considera-se que, para evitar a mastite e valores altos de CCS e CPP, é preciso realizar um conjunto de manejos desde a ordenha até a destinação do leite para os laticínios. O objetivo principal da revisão consistiu em discorrer sobre os impactos da mastite sobre a produção e a qualidade do leite cru. Estudos indicam a existência de uma correlação negativa entre aumento da CCS e redução do volume de leite produzido. Além disso, leites com alta CCS apresentam alteração da composição, como redução do teor de sólidos e da proporção caseínas/proteínas do soro. Portanto, foi possível concluir que a mastite interfere negativamente na produção e na qualidade do leite, destacando a necessidade de prevenir sua ocorrência e identificar, isolar e tratar animais acometidos.

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Streptococcus agalactiae virulence factors isolated from bovine mastitis and antibiotic treatment response

Torres,

Macias,

Reyes-Vélez

et al. 2023

Journal of Applied Microbiology

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Aims This study aims to characterise the virulence factors of S. agalactiae strains isolated from bovine mastitis and their potential association with the antibiotic treatment response. Methods and results Four different profiles were identified among the 181 S. agalactiae strains using polymerase chain reaction, of which hyl B and cylE were found in 100% of the isolated strains, followed by cfb (99.5%), scpB (40.3%), and lmb (15.5%). The cell invasion assay showed that lmb-positive strains exhibited higher invasion ability than lmb-negative. There was a significant association (P = 0.018) between lmb gene and cows that required more than one treatment cycle. Conclusions These results showed that intramammary infections caused by lmb-carrier S. agalactiae strains did not adequately respond to the antibiotics administered, likely because of the presence of this virulence factor, which potentially favours the cell invasion capacity of these strains.

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Factors associated with microbiological and clinical cure of mastitis in dairy cows

Cited by 3 publications

References 19 publications

Efficacy of antimicrobial therapy in association with vaccination on the bacteriological cure of subclinical mastitis caused by Staphylococcus aureus in lactating cows

Efficacy of antimicrobial therapy in association with vaccination on the bacteriological cure of subclinical mastitis caused by Staphylococcus aureus in lactating cows

Influência da mastite sobre a produção e a qualidade do leite cru

Streptococcus agalactiae virulence factors isolated from bovine mastitis and antibiotic treatment response

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