Factors Associated With Hearing Impairment in Patients With Congenital Hypothyroidism Treated Since the Neonatal Period: A National Population-Based Study

Lichtenberger-Geslin, Lydia; Santos, Sophie Dos; Hassani, Yasmine; Écosse, Emmanuel; Abbeele, T. Van Den; Léger, Juliane

doi:10.1210/jc.2013-1645

Cited by 63 publications

(51 citation statements)

References 39 publications

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“…One study investigated 12 older patients, at the age of 20 years, and suggested that auditory processing abnormalities persisted in these patients (59). In our nationwide study of 1202 young adult patients, we have recently shown that, at a median age of 23.4 years, a significantly larger proportion of the CH population than of the general population reported having hearing impairment (9.5 vs 2.5%) and that the risk of developing hearing impairment was more than three times higher in these patients than in the reference population (29,60). Hearing loss was mostly detected during childhood, at a median (23-75th percentile) age of 7.0 (3.4-19.0) years and 17% of the patients who declared hearing impairment at a median age of 23.4 years had required a hearing aid since a median age of 10 years.…”

Section: Neurosensory Developmentmentioning

confidence: 84%

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Léger

2015

European Journal of Endocrinology

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Congenital hypothyroidism (CH) is the most common congenital endocrine disorder. The early treatment of CH patients has successfully improved the prognosis and management of this disorder. Optimal treatment and management throughout the patient's life, beginning in the neonatal period, are required to ensure long-term health. Affected patients should be offered assessments of associated medical conditions and provided with accurate information about their condition throughout their lives, but particularly during the transition from pediatric to adult services. This review provides a summary of current knowledge about the long-term outcomes of these patients and appropriate management into early adulthood. We carried out a systematic search of the Medline database to identify relevant articles. Despite major improvements in prognosis, the impact of CH is clearly not uniform, and management should take into account a broader range of relevant indicators, including CH severity, associated comorbid conditions and the adequacy of treatment during childhood and adulthood. The early diagnosis and management of associated medical conditions, and better educational strategies to improve compliance with treatment, should improve the long-term prognosis. Further studies are required to explore changes with aging.

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Section: Neurosensory Developmentmentioning

confidence: 84%

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Léger

2015

European Journal of Endocrinology

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“…Thus, several audiological findings are possible. However, the audiometric disturbances are frequently described as having the following features: sensorineural, bilateral, symmetric, mainly in high frequencies, in a varying degree, and are often mild to moderate severity (6,7,(41)(42)(43)(44)(45)(46). Conductive hearing loss and tympanometric abnormalities in addition to acoustic middle ear reflex have also been described in several studies (5,6,7,(41)(42)(43).…”

Section: Retrocochlear/central Mechanisms On Congenital Hypothyroidismmentioning

confidence: 99%

Mechanisms involved in hearing disorders of thyroid ontogeny: a literature review

Andrade

Machado

Fernandes

et al. 2017

Arch. Endocrinol. Metab.

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Endocochlear, retrocochlear and/or central origin hearing damage may be related to the absence of appropriate levels of thyroid hormone during morphogenesis and/or auditory system development. Hearing disorders related to the thyroid are not well studied, despite speculation on the pathophysiological mechanisms. The objective of this review was to characterize the main pathophysiological mechanisms of congenital hypothyroidism and to evaluate the relationship with central and peripheral hearing disorders. We conducted a literature review using the databases MedLine, LILACS, Cochrane Library, SciELO, Institute for Scientific Information (ISI), Embase, and Science Direct between July and September on 2016. We identified the studies that address hearing disorder mechanisms on the congenital hypothyroidism. Congenital hypothyroidism may have clinical and subclinical manifestations that affect the auditory system and may be a potential risk factor for hearing impairment. Hearing impairment can severely impact quality-of-life, which emphasizes the importance of monitoring and evaluating hearing during the clinical routine of these patients. Arch Endocrinol Metab. 2017;61(5):501-5

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“…No entanto, a exata prevalência da perda auditiva nos portadores de HC permanece em discussão. Estima-se que o risco de desenvolver perda auditiva nessa população seja de duas a quatro vezes maior que na população geral de crianças para a mesma faixa etária 25 , podendo afetar cerca de 20% dos portadores de HC 4 . É importante destacar que a frequência de hipoacusia encontrada no presente estudo não reflete necessariamente a presença de perda auditiva, com redução nos limiares tonais.…”

Section: Os Indivíduos Apresentamunclassified

Prevalência de sintomas otoneurológicos em indivíduos com hipotireoidismo congênito: estudo piloto

et al. 2017

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Resumo Objetivo Investigar a frequência de sintomas otoneurológicos em crianças com hipotireoidismo congênito e relacioná-los com os aspectos clínicos. Métodos Estudo exploratório de caráter descritivo seccional. A casuística foi composta pelos pais e/ou cuidadores de 105 crianças com diagnóstico de hipotireoidismo congênito e com 5 anos ou mais de idade. A coleta de dados utilizou um questionário estruturado elaborado e testado pelos pesquisadores. As informações clínicas e laboratoriais foram obtidas dos prontuários médicos. Resultados A maioria dos indivíduos (72,4%) demonstrou sintomas relacionados à disfunção vestibulococlear, na qual a tontura/vertigem correspondeu a 56,2% dos sintomas, seguida pela hipoacusia (43,8%) e pelo zumbido (12,4%). Houve correlação estatística entre os sintomas de hipoacusia (p=0,016) e a idade para o teste de rastreio neonatal, bem como os sintomas de tontura/vertigem com a etiologia do hipotireoidismo congênito (p=0,003). Na percepção da hipoacusia (RP=0,49; IC=0,31-0,77), a exposição ao fator demonstrou associação com a probabilidade de 95%. Conclusão Os achados sugerem significativa prevalência e associação entre hipotireoidismo congênito e sintomas otoneurológicos, especialmente tontura, hipoacusia e zumbido.

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Factors Associated With Hearing Impairment in Patients With Congenital Hypothyroidism Treated Since the Neonatal Period: A National Population-Based Study

Abstract: Despite major improvements in prognosis, hearing loss remains a significant problem, particularly in patients with severe CH. Parents and primary care providers should be aware of this risk, because early diagnosis and intervention could improve the long-term prognosis in these patients.

Cited by 63 publications

References 39 publications

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Mechanisms involved in hearing disorders of thyroid ontogeny: a literature review

Prevalência de sintomas otoneurológicos em indivíduos com hipotireoidismo congênito: estudo piloto

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