Factors Associated With Decisions to Undergo Surgery Among Patients With Newly Diagnosed Early-Stage Lung Cancer

Cykert, Samuel

doi:10.1001/jama.2010.793

Cited by 236 publications

(196 citation statements)

References 40 publications

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“…Even studies from United States demonstrate that 30-60% of cases of early stage lung cancer don't undergo surgery. They found racial differences in proportion of patients undergoing surgery, apart from disease related factors and co morbidities (Esnaola et al, 2008;Cykert et al, 2010). In our study, 39.08% of NSCLC and 36.7% of SCLC patients received radiotherapy to the primary site, out of which only 29.4% (of patients receiving radiotherapy) of NSCLC and 27.7% of SCLC, received radiotherapy in radical doses.…”

Section: Discussionmentioning

confidence: 46%

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Malik¹,

Sharma²,

Mohanti³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Lung cancer is one of the commonest and most lethal cancers throughout the world. The epidemiological and pathological profile varies among different ethnicities and geographical regions. At present adenocarcinoma is the commonest histological subtype of non-small cell lung cancer (NSCLC) in most of the Western and Asian countries. However, in India squamous cell carcinoma has been reported as the commonest histological type in most of the series. The aim of the study was to analyze the current clinico-pathological profile and survival of lung cancer at our centre. Materials and Methods: We analyzed 434 pathologically confirmed lung cancer cases registered at our centre over a period of three years. They were evaluated for their clinical and pathological profiles, treatment received and outcome. The available histology slides were reviewed by an independent reviewer. Results: Median age was 55 years with a male:female ratio of 4.6:1. Some 68% of patients were smokers. There were 85.3% NSCLC and 14.7% SCLC cases. Among NSCLCs, adenocarcinoma was the commonest histological subtype after the pathology review. Among NSCLC, 56.8% cases were of stage IV while among SCLC 71.8% cases had extensive stage disease. Some 29% of patients did not receive any anticancer treatment. The median overall and progression free survivals of the patients who received treatment were 12.8 and 7.8 months for NSCLC and 9.1 and 6.8 months for SCLC. Conclusions: This analysis suggests that adenocarcinoma may now be the commonest histological subtype also in India, provided a careful pathological review is done. Most of the patients present at advanced stage and outcome remains poor.

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Section: Discussionmentioning

confidence: 46%

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Malik¹,

Sharma²,

Mohanti³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Stage at diagnosis and treatment type are especially important in NSCLC patients given early-stage disease is potentially curable by surgical resection (3). At least half of patients who undergo surgical treatment survive more than 5 years, whereas, without surgery, most will die within a year (3)(4)(5). Although surgical resection remains the only reliable treatment for early-stage NSCLC, 29% of patients do not receive surgical treatment (3,5,6).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Residential Segregation and Neighborhood Characteristics on Surgery and Survival in Patients with Early-Stage Non–Small Cell Lung Cancer

Johnson

Hines

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Although the negative effects of lower socioeconomic status on non-small cell lung cancer (NSCLC) treatment and survival have been widely studied, the impact of residential segregation on prognosis and the receipt of treatment has yet to be determined.Methods: This is a retrospective, cohort study of NSCLC patients in Georgia (2000-2009; n ¼ 8,322) using data from the Georgia Comprehensive Cancer Registry. The effects of segregation, economic deprivation, and combined segregation/deprivation on the odds of receiving surgery were examined in separate multilevel models. To determine the association for the exposures of interest on the risk of death for different racial groups, separate multilevel survival models were conducted for black and white patients.Results: Living in areas with the highest [AOR ¼ 0.35, 95% confidence interval (CI), 0.19-0.64] and second highest

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“…7,8 Relatively lower cancer mortality among US Hispanics is consistent with the so-called Hispanic paradox, referring to better health relative to NHWs despite disadvantages in socioeconomic status (SES). [9][10][11] Reasons for the observed NSCLC mortality paradox among US Hispanics have not been identified.…”

Section: Introductionmentioning

confidence: 89%

How Do Social Factors Explain Outcomes in Non–Small-Cell Lung Cancer Among Hispanics in California? Explaining the Hispanic Paradox

Patel

Schupp

Gomez

et al. 2013

JCO

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Purpose Hispanics in the United States have lower age-adjusted mortality resulting from non–small-cell lung cancer (NSCLC) compared with non-Hispanic whites (NHWs). The purpose of this study was to evaluate individual, clinical, and neighborhood factors in survival among Hispanics with NSCLC. Patients and Methods We performed a retrospective analysis of NHWs and Hispanics with NSCLC between 1998 and 2007 in the California Cancer Registry (follow-up to December 2009). Kaplan-Meier curves depict survival by nativity for Hispanics with NSCLC. Cox proportional hazards models estimated hazard of mortality by race with adjustment for individual (age, sex, marital status), clinical (histologic grade, surgery, irradiation, chemotherapy), and neighborhood factors (neighborhood socioeconomic status, ethnic enclave). Results We included 14,280 Hispanic patients with NSCLC. Foreign-born Hispanics had 15% decreased risk of disease-specific mortality resulting from NSCLC compared with NHWs (hazard ratio [HR], 0.85; 95% CI, 0.83 to 0.88) after adjustment for individual, clinical, and neighborhood factors. After adjustment for individual factors, compared with US-born Hispanics, foreign-born Hispanics had 10% decreased risk of disease-specific mortality (HR, 0.90; 95% CI, 0.87 to 0.96). Clinical and neighborhood factors slightly moderated the survival benefit for foreign-born patients. A modestly more pronounced survival advantage was seen for foreign-born Hispanics living in low socioeconomic and high Hispanic enclave neighborhoods as compared with US-born Hispanics (HR, 0.86; 95% CI, 0.81 to 0.90). Conclusion Foreign-born Hispanics with NSCLC have a decreased risk of disease-specific mortality compared with NHWs and US-born Hispanics with NSCLC. Neighborhood factors slightly moderate this survival advantage. This survival advantage is slightly more pronounced in lower socioeconomic and higher Hispanic enclave neighborhoods.

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Factors Associated With Decisions to Undergo Surgery Among Patients With Newly Diagnosed Early-Stage Lung Cancer

Cited by 236 publications

References 40 publications

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

The Effects of Residential Segregation and Neighborhood Characteristics on Surgery and Survival in Patients with Early-Stage Non–Small Cell Lung Cancer

How Do Social Factors Explain Outcomes in Non–Small-Cell Lung Cancer Among Hispanics in California? Explaining the Hispanic Paradox

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