Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Malik, Prabhat Singh; Sharma, Mehar Chand; Mohanti, Bidhu Kalyan; Shukla, N.K.; Deo, S.V.S.; Mohan, Anant; Kumar, Guresh; Raina, Vinod

doi:10.7314/apjcp.2013.14.1.489

Cited by 93 publications

(90 citation statements)

References 28 publications

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“…The association of low serum albumin with poor OS and PFS is in accordance with Malik et al (5). Low serum albumin indicates depleted nutritional status and may result in poor response to treatment and outcome (15).…”

Section: Discussionsupporting

confidence: 68%

Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India

et al. 2016

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Objectives: To evaluate treatment compliance, toxicity and survival in geriatric patients (≥65 years) with locally advanced nonsmall cell lung cancer (LA-NSCLC).Methods: Departmental archive was collected for the details of demographics, treatment and outcome in elderly patients with LA-NSCLC (2008 -2013) (n = 96). Both progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan-Meier method. Acute and late morbidity were scored using common terminology criteria for adverse events version 4, radiation therapy and oncology group late morbidity scoring system. Results:Overall treatment completion rate was 65%. The rates of acute grade ≥ 3 hematologic and non-hematologic toxicities were 20% and 17% respectively. Overall rate of late toxicity was 12.5%. The median PFS and OS values were 7.4 months and 10.54 months, respectively. Patients with multiple comorbidities, poor socio-economic background and serum albumin level (< 3.5g/dL) were observed to have poor survival. Survival was lower for non-compliant patients. Conclusions:Curative multi-modality therapy in elderly patients with LA-NSCLC is a challenging task. They are susceptible to poor compliance, treatment-associated toxicities and poor survival.

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Section: Discussionsupporting

confidence: 68%

Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India

et al. 2016

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“…This is in contrast to some of the previous Indian studies which showed squamous cell carcinoma to be the most frequent subtype; but similar to the findings of some recent studies in India which shows a changing pattern of lung carcinoma from squamous cell carcinoma to adenocarcinoma. [5][6][7][8] This change may be due to changes in smoking habits. Most of the masses (92%) showed heterogeneous contrast enhancement on CT scan.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and staging of lung carcinoma with CT scan and its histopathological correlation

et al. 2017

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INTRODUCTIONLung carcinomas are a group of tumors that arise from any part of trachea, bronchi, bronchioles or the pulmonary parenchyma and can be derived from the cells of epithelium, mesenchyme and neural origin. Thus, it is a heterogenous entity both in the variety of cell type and in the biological behaviour of any particular cell type. Bronchogenic carcinoma is the most common cause of cancer-related death in men and second most common in women, worldwide. Imaging studies play a key role in the detection, staging and post-treatment follow up of patients with bronchogenic carcinoma. The strongest prognostic factor for survival in lung cancer cases is respectability of the tumor. Thus, accurate staging of the bronchogenic carcinoma is essential as the choice of treatment options ABSTRACT Background: Lung cancer is the most common cancer worldwide. Hence, timely diagnosis and accurate staging of the carcinoma is critical for the treatment and prognosis. So, this study was performed to evaluate the role of CT scan in diagnosis and staging of lung cancer. Methods: This was a prospective and observational study carried out over one and half years at a tertiary care hospital. The patients found to have abnormalities on chest X-ray suggestive of carcinoma were included in the study. Pre and post contrast CT scans were performed. Individual patient biopsies were done for histopathological staging. Results: Most patients belonged to 41-50 years age group with male preponderance (81.33%). Habit of smoking was prevalent among the lung cancer patients. Almost all masses (92%) showed heterogeneous contrast enhancement on CT. Additionally, there were calcifications, cavitation, hilar enlargement, pleural invasion, mediastinal lymphadenopathy and contiguous bone involvement. Adenocarcinoma was the most common (46.66%) form of cancer followed by squamous cell carcinoma (42.66%). For histopathological diagnosis, majority of patients (73.33%) were diagnosed using CT guided biopsy. In the remaining patients, USG guided biopsy or fibreoptic bronchoscopy were performed. The most common lobe affected by bronchogenic carcinoma was right upper lobe. The most common site of metastasis was pleura (22.66%) followed by bone (17.33%). Majority of the patients (41.33%) presented with TNM stage IV. Conclusions: CT scan as a modality for detection and staging of bronchogenic carcinoma is superior to chest radiograph. CT guided FNAC has a high success rate in evaluation of lung carcinoma.

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“…In China, lung cancer is more common than stomach and liver cancer, and is the first cause of death from malignant tumors (Hu et al, 2013). However, conventional disgnositc methods, eg., imaging, fiber bronchoscope, cytology and histopathologic is difficult for early detection of lung cancer (Malik et al, 2013). Recently, tumor markers is suggested to be a usefull tool in this setting, especially in early diagnosis of lung cancer (Buccheri et al, 2002;Schneider et al, 2002;Kav et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Clinical Observations on the Association Between Diagnosis of Lung Cancer and Serum Tumor Markers in Combination

Wang¹,

Tao²,

Gu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: To evaluate the association of a diagnosis of lung cancer and combined detection of serum carcinoembryonic antigen (CEA), carbohydrateantigen 19-9 (CA19-9), neuron specific enolase (NSE) as well as the cytokeratin 19 fragment (CYFRA21-1). Methods: Serum CEA, CA19-9, NSE and CYFRA21-1 were assessed in 150 patients with lung cancer, 100 patients with benign lung disease and 100 normal control subjects, and differences of expression were compared in each group, and joint effects of these tumor markers in the diagnosis of lung cancer were analyzed. Results: Serum CEA, CA19-9, NSE and CYFRA21-1 in patients with lung cancer were significantly higher than those with benign lung disease and normal controls (p<0.01). It is suggested that these four tumor markers combined together could produce a positive detection rate of 90.2%, significantly higher than that of any single test. Conclusion: Combination detection of CEA, CA19-9, NSE and CYFRA21-1 could significantly improve the sensitivity and specificity in diagnosis of lung cancer, and could be important in early detection.

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Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Cited by 93 publications

References 28 publications

Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India

Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India

Diagnosis and staging of lung carcinoma with CT scan and its histopathological correlation

Clinical Observations on the Association Between Diagnosis of Lung Cancer and Serum Tumor Markers in Combination

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