Factors affecting the variation of bioactive compounds in<i>Hypericum</i>species

Çırak, Cüneyt; Radušienė, Jolita

doi:10.1556/019.70.2019.25

Cited by 24 publications

(19 citation statements)

References 114 publications

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“…Remarkable amounts of naphthodianthrones have been determined earlier in other species of the section Drosocarpium. This finding reinforces previous observations that hypericins are produced only in phylogenetically advanced clades of the genus as Hypericum and Drosocarpium (Crockett and Robson 2011;Cirak and Radusiene 2019), as a result of adaptation to selective factors.…”

Section: Resultssupporting

confidence: 91%

“…The methanolic extract of H. vesiculosum contains only a few phloroglucinols, which were not thoroughly identified, and only one could be quantified (0.51 ± 0.04 mg/g of dry extract). Hyperforin has been determined in many Hypericum species including those of Drosocarpium, i.e., H. montbretia Spach, H. bithynicum Boiss., and H. perfoliatum (Smelcerovic and Spiteller 2006;Cirak and Radusiene 2019), but our LC-MS study does not demonstrate its presence in H. vesiculosum.…”

Section: Resultscontrasting

confidence: 83%

“…2,3,4,5,6 2.83 ± 0.02 f (Table S1). These compounds have been determined in other Drosocarpium species (Cirak and Radusiene 2019). Eighteen compounds were quantified by HPLC (Table 1, Fig.…”

Section: Resultsmentioning

confidence: 99%

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Anatomical Characterization and UHPLC-MS Analysis of Hypericum vesiculosum

Ζέλιου

Vogiatzoglou

Kalachanis

et al. 2020

Rev. Bras. Farmacogn.

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In this study, we characterized Hypericum vesiculosum Griseb. (sect. Drosocarpium), Hypericaceae, a Balkan endemic and Greek subendemic species, which was collected from the Peloponnese (Greece). The anatomical study showed that its leaves are dorsiventral and hypostomatic, and the major part of its circular stem is filled with xylem. High-performance liquid chromatography coupled with diode-array detection and mass spectrometry analysis of the methanolic extract of the aerial parts revealed 25 compounds, and the concentration of the 18 major ingredients was determined with a validated method of liquid chromatography coupled with diode-array detection. Flavonoids were the most abundant group of compounds (> 100 mg/g of dry extract) with I3,II8-biapigenin, apigenin hexoside, isoquercitrin, quercetin, and hyperoside as the major dereplicated constituents. Chlorogenic acid was abundant (9.34 ± 0.22 mg/g) and the content of naphthodianthrones was comparable to that in H. perforatum. Only one phloroglucinol could be quantified at a very low concentration and that was not hyperforin. This is the first chemical analysis of its methanolic extract and anatomical characterization of its vegetative tissues.

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Section: Resultssupporting

confidence: 91%

Section: Resultscontrasting

confidence: 83%

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Anatomical Characterization and UHPLC-MS Analysis of Hypericum vesiculosum

Ζέλιου

Vogiatzoglou

Kalachanis

et al. 2020

Rev. Bras. Farmacogn.

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“…However, many other factors. including the temperature and light intensity 18 , 20 also influence these properties.…”

Section: Introductionmentioning

confidence: 99%

Harvest time affects antioxidant capacity, total polyphenol and flavonoid content of Polish St John’s wort’s (Hypericum perforatum L.) flowers

Makarova

Sajkowska-Kozielewicz

Zawada

et al. 2021

Sci Rep

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The polyphenol content and antioxidant capacity of hyperforin and hypericin-standardized H. perforatum L. extracts may vary due to the harvest time. In this work, ethanol and ethanol–water extracts of air-dried and lyophilized flowers of H. perforatum L., collected throughout a vegetation season in central Poland, were studied. Air-dried flowers extracts had higher polyphenol (371 mg GAE/g) and flavonoid (160 mg CAE/g) content, DPPH radical scavenging (1672 mg DPPH/g), ORAC (5214 µmol TE/g) and FRAP (2.54 mmol Fe2+/g) than lyophilized flowers extracts (238 mg GAE/g, 107 mg CAE/g, 1287 mg DPPH/g, 3313 µmol TE/g and 0.31 mmol Fe2+/g, respectively). Principal component analysis showed that the collection date influenced the flavonoid and polyphenol contents and FRAP of ethanol extracts, and DPPH and ORAC values of ethanol–water extracts. The ethanol extracts with the highest polyphenol and flavonoid content protected human erythrocytes against bisphenol A-induced damage. Both high field and benchtop NMR spectra of selected extracts, revealed differences in composition caused by extraction solvent and raw material collection date. Moreover, we have shown that benchtop NMR can be used to detect the compositional variation of extracts if the assignment of signals is done previously.

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“…[13] Moreover, some environmental abiotic and biotic factors, such as light, temperature, and radiation, are influenced by altitude. Cirak and Radusiene [14] reported that growing plant sites' altitude had stimulated secondary metabolism greatly as lower temperatures and higher UV-B radiation predominate at higher altitudes. Another study performed by Abreu and Mazzafera [15] observed a significant increase in total phenols and flavonoids in Hypericum species due to low-temperature treatments.…”

Section: Introductionmentioning

confidence: 99%