Harvest time affects antioxidant capacity, total polyphenol and flavonoid content of Polish St John’s wort’s (Hypericum perforatum L.) flowers

Makarova, Katerina; Sajkowska-Kozielewicz, Joanna J.; Zawada, Katarzyna; Olchowik-Grabarek, Ewa; Ciach, Michał; Gogolewski, Krzysztof; Dobros, Natalia; Ciechowicz, Paulina; Freichels, Hélène; Gambin, Anna

doi:10.1038/s41598-021-83409-4

Cited by 20 publications

(12 citation statements)

References 49 publications

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“…Hypercum perforatum L. (Hypericaceae), is one of the most famous medicinal plants in the world. Its popularity is due to its wide range of medicinal applications [38][39][40]. In the literature, some authors also demonstrate the antimicrobial activity of H. perforatum extracts against Gram-positive bacteria [41][42][43], which is confirmed by our data.…”

Section: Discussionsupporting

confidence: 87%

Bulgarian Medicinal Extracts as Natural Inhibitors with Antiviral and Antibacterial Activity

Nikolova

Paunova-Krasteva

Petrova

et al. 2022

Plants

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Background: Bulgaria is a country with a wide range of medicinal plants, with uses in traditional medicine dating back for centuries. Methods: Disc diffusion assay was used to evaluate the antimicrobial activity of the plant extracts. A cytopathic effect inhibition test was used for the assessment of the antiviral activity of the extracts. The virucidal activity of the extracts, their influence on the stage of viral adsorption, and their protective effect on uninfected cells were reported using the end-point dilution method, and Δlgs was determined as compared to the untreated controls. Results: The results of the study reveal that the antibacterial potential of G. glabra and H. perforatum extracts in Gram-positive bacteria is more effective than in Gram-negative bacteria. When applied during the replication of HSV-1 and HCov-OC-43, only some of the extracts showed weak activity, with SI between 2 to 8.5. Almost all tested extracts inhibited the extracellular virions of the studied enveloped viruses (HSV-1 and HCov-OC-43) to a greater extent than of the non-enveloped viruses (PV-1 and HAdV-5). They inhibited the stage of viral adsorption (HSV-1) in the host cell (MDBK) to varying degrees and showed a protective effect on healthy cells (MDBK) before they were subjected to viral invasion (HSV-1). Conclusion: The antipathogenic potential of extracts of H. perforatum and G. glabra suggests their effectiveness as antimicrobial agents. All 13 extracts of the Bulgarian medicinal plants studied can be used to reduce viral yield in a wide range of viral infections.

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Section: Discussionsupporting

confidence: 87%

Bulgarian Medicinal Extracts as Natural Inhibitors with Antiviral and Antibacterial Activity

Nikolova

Paunova-Krasteva

Petrova

et al. 2022

Plants

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“…These compounds and their structural analogs have already shown synergistic antioxidant effects and anti lipid peroxy radical properties [32,33]. The phenolic and flavonoid content of Hypericum specimens undergo significant quantitative alterations during the vegetative stages [34][35][36]. The total phenolic content of the samples S6, S9 and S10 were found to be in close agreement with the average phenolic content previously reported for Hypericum species (150.44 mg GAE/g of dried extract), using ethanol as extraction solvent.…”

Section: Fig 2 Hptlc Of Methanolic Extracts Visualized With Anisaldeh...supporting

confidence: 84%

Assessment of Authenticity of Market Samples of Hypericum using Phytochemical Fingerprinting Tools

Jahromi

Zarshenas

Rizvandi

2022

EJMP

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Aims: Hypericum perforatum L., known as “Hofarighun” is a widely used herbal drug in Traditional Persian Medicine (TPM). Detection of non-relevant plants, instead of this species, in the herbal market encourages the need for the establishment of it’s chemical authentication and standardization, through implying rapid and efficient phytochemical techniques. Study Design: Twelve Hypericum samples were acquired from traditional medicine markets of different regions of Iran (Tehran, Sanandaj, Mashhad, Kerman, Bandar Abbas, Ahvaz, Yazd, Babol, Yasuj, Shiraz (Chehel Giah), Shiraz (Kazerun Gate), and Shiraz (Adloo Zerehi), based on microscopic characterization. Positive control was taken in the form of cultivated specimen of H. perforatum. Place and Duration of Study: Study was performed in Medicinal plants processing Research Center, SUMS, Shiraz in the months between February to December 2021. Methodology: Essential oil samples were injected into a gas chromatograph (GC) and compounds were identified as per the spectra obtained. Total phenol, flavonoid and HPTLC analysis of samples were also done. Results: α-pinene was found in highest proportion in majority of samples i.e. 35.55-63.69%. However other compounds such as 1-dodecanol (10.82%), caryophyllene (15.87%) and β-cubebene (15.14%) were also analyzed in samples and the cultivated sample respectively. Total phenol and flavonoid content among the Hypericum extracts were found to be between 50.31±3.22 to 262.76±8.12 mg Gallic Acid Equivalent (GAE)/g of Ext. and 13.47±1.68 to 79.26±5.78 mg Quercetin Equivalent (QE)/g of Ext., respectively. Conclusion: The noticeable findings of present study can be used as a framework for authentication of Hypericum perforatum samples. The methods used were found to be feasible and efficient in detection of adultrations and may contribute to minimize the safety and efficacy concerns over the samples available in the traditional herbal pharmacies.

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“…The greater reduction observed here may be due to differences in substrate addition and replacement, or the study by Jafari et al [ 21 ] showed a linearly decreasing trend in total VFA with increasing doses of bamboo leaves, or both. Furthermore, it may be because the chemical compositions of plants are influenced by their geographic origin, harvest stage, and age [ 54 , 55 ]. The lower abundance of methanogenic archaea following PHN supplementation may support this result.…”

Section: Discussionmentioning

confidence: 99%

Dose–Response Effects of Bamboo Leaves on Rumen Methane Production, Fermentation Characteristics, and Microbial Abundance In Vitro

Lee

Kim

et al. 2022

Animals

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Ruminants produce large amounts of methane as part of their normal digestive processes. Recently, feed additives were shown to inhibit the microorganisms that produce methane in the rumen, consequently reducing methane emissions. The objective of this study was to evaluate the dose–response effect of Phyllostachys nigra var. henonis (PHN) and Sasa borealis supplementation on in vitro rumen fermentation, methane, and carbon dioxide production, and the microbial population. An in vitro batch culture system was used, incubated without bamboo leaves (control) or with bamboo leaves (0.3, 0.6, and 0.9 g/L). After 48 h, total gas, methane, and carbon dioxide production decreased linearly with an increasing dose of bamboo leaves supplementation. The total volatile fatty acid, acetate, and acetate-to-propionate ratio were affected quadratically with increasing doses of bamboo leaves supplementation. In addition, propionate decreased linearly. Butyrate was increased linearly with increasing doses of PHN supplementation. The absolute values of total bacteria and methanogenic archaea decreased linearly and quadratically with an increasing dose of PHN treatment after 48 h. These results show that bamboo leaves supplementation can reduce methane production by directly affecting methanogenic archaea, depressing the metabolism of methanogenic microbes, or transforming the composition of the methanogenic community. These results need to be validated using in vivo feeding trials before implementation.

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Harvest time affects antioxidant capacity, total polyphenol and flavonoid content of Polish St John’s wort’s (Hypericum perforatum L.) flowers

Cited by 20 publications

References 49 publications

Bulgarian Medicinal Extracts as Natural Inhibitors with Antiviral and Antibacterial Activity

Bulgarian Medicinal Extracts as Natural Inhibitors with Antiviral and Antibacterial Activity

Assessment of Authenticity of Market Samples of Hypericum using Phytochemical Fingerprinting Tools

Dose–Response Effects of Bamboo Leaves on Rumen Methane Production, Fermentation Characteristics, and Microbial Abundance In Vitro

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