Factors affecting radiographic progression of knee osteoarthritis.

Ledingham, Joanna; Regan, Marian; Jones, Adrian; Doherty, Michael

doi:10.1136/ard.54.1.53

Cited by 152 publications

(126 citation statements)

References 26 publications

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“…In the comparison of the second quartile versus the first quartile, no statistically significant association was found. Ledingham et al (21) only found a significant association for the relationship of BMI with JSN. In that study, a borderline significant association was found for the relationship with the change in osteophytes and no statistical association was found in the relationship between change in K/L grade.…”

Section: Resultsmentioning

confidence: 91%

“…(31) reported no significant association between sex and progression of knee OA. Ledingham et al (21) reported an association between sex and the change in cyst number but not between sex and change in K/L grade or joint space narrowing (JSN). Miyazaki et al (22), Schouten et al (37), Spector et al (39), and Wolfe and Lane (45) found no significant association between sex and progression of knee OA.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Belo¹,

Berger²,

Reijman³

et al. 2007

Arthritis & Rheumatism

165

132

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Objective. To provide an overview of prognostic factors of knee osteoarthritis (OA) progression. Methods. We searched Medline and Embase up to December 2003 according to a specified search strategy (keywords for disease, location, and study design). Studies that fulfilled predefined criteria were assessed for methodologic quality. Study characteristics and associations were extracted and the results were summarized according to a best evidence synthesis. Results. Of the 1,004 studies found, 37 met the inclusion criteria. Methodologic quality was assessed and only highquality studies were included (n ‫؍‬ 36). The best evidence synthesis yielded strong evidence that hyaluronic acid serum levels and generalized OA are predictive for progression of knee OA. Sex, knee pain, radiologic severity, knee injury, quadriceps strength, and regular sport activities were not predictive. Conflicting evidence for associations was found for several factors including body mass index and age. Limited evidence for an association with progression of knee OA was found for several factors, including the alignment (varus/valgus) of the joint. Limited evidence for no association with progression of OA was also found for several factors, including meniscectomy, several markers of bone or cartilage turnover, and the clinical diagnosis of localized OA. Conclusion. Generalized OA and level of hyaluronic acid seem to be associated with the radiologic progression of knee OA. Knee pain, radiologic severity at baseline, sex, quadriceps strength, knee injury, and regular sport activities seem not to be related. For other factors, the evidence was limited or conflicting.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Belo¹,

Berger²,

Reijman³

et al. 2007

Arthritis & Rheumatism

165

132

View full text Add to dashboard Cite

show abstract

“…If studies of the same cohort presented different information, reported on different prognostic factors (28,29), or presented results after different followup periods (30,31), both studies were included. In total, 18 studies were included in this review (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44). A list of excluded studies is presented in Appendix 1 on the NIVEL Web site (available at: http://www.nivel.nl/systeem/scripts/downloadtracker.…”

Section: Resultsmentioning

confidence: 99%

Course of functional status and pain in osteoarthritis of the hip or knee: A systematic review of the literature

Dijk

Dekker

Veenhof

et al. 2006

Arthritis & Rheumatism

216

150

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Objective. To systematically review studies describing the course of functioning in patients with osteoarthritis (OA) of the hip or knee and identifying potential prognostic factors. Methods. A systematic search was performed. Studies involving patients with hip or knee OA, >6 months of followup, and outcome measures on functional status or pain were included. Methodologic quality was assessed using a standardized set of 11 criteria; a qualitative data analysis was performed.Results. Approximately 6,500 titles and abstracts were screened and 48 publications were considered for inclusion. Eighteen studies, 4 of which met the high methodologic quality criteria, were included. For hip OA, there was limited evidence that functional status and pain do not change during the first 3 years of followup. After 3 years, however, a worsening of functional status and pain was seen. For knee OA, there was conflicting evidence for the first 3 years and limited evidence for worsening of pain and functional status after 3 years. Furthermore, limited evidence was established for negative associations between future functional status and laxity, proprioceptive inaccuracy, age, body mass index, and knee pain intensity. In contrast, greater muscle strength, better mental health, better self-efficacy, social support, and more aerobic exercise were protective factors in the first 3 years. Conclusion. Pain and functional status in hip or knee OA seem to deteriorate slowly, with limited evidence for worsening after 3 years of followup. In specific subgroups, prognosis in the first 3 years of followup was either worse or better, as both risk factors and protective factors were identified. Prognostic factors included biomechanical factors, psychological factors, clinical factors, and treatment modalities. To strengthen the evidence, further high-quality longitudinal research on hip or knee OA functioning is needed.

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“…As stated by Boegard, Ledingham, Lanyon, and Fernandez-Cuadros (2,(7)(8)(9), the collapse of the medial compartment produces abnormal forces that could contribute to changes in the lateral compartment, increasing the JSW as a result. In that scenario, the protective effect of Glu/CS on the lateral compartment and the nonprotective effect in the medial compartment could be just a result of progression in the natural history of knee OA (2,(7)(8)(9).…”

Section: To the Editormentioning

confidence: 98%

“…In that scenario, the protective effect of Glu/CS on the lateral compartment and the nonprotective effect in the medial compartment could be just a result of progression in the natural history of knee OA (2,(7)(8)(9). Because of all the arguments exposing the long-term effects of Glu/CS on the progression of structural changes in knee OA, the asseveration that Glu/CS protects the lateral but not the medial compartment, based on radiographic assumptions, should be taken with caution.…”

Section: To the Editormentioning

confidence: 99%

Does glucosamine/chondroitin sulfate have a long‐term effect on the progression of structural changes in knee osteoarthritis? Comment on the article by Raynauld et al

Fernández-Cuadros

2017

Arthritis Care & Research

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Factors affecting radiographic progression of knee osteoarthritis.

Abstract: 3-17, respectively); warmth at the knee associated with change in any radiographic feature (odds ratio 2-22; 95% CI

Cited by 152 publications

References 26 publications

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Course of functional status and pain in osteoarthritis of the hip or knee: A systematic review of the literature

Does glucosamine/chondroitin sulfate have a long‐term effect on the progression of structural changes in knee osteoarthritis? Comment on the article by Raynauld et al

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