Does glucosamine/chondroitin sulfate have a long‐term effect on the progression of structural changes in knee osteoarthritis? Comment on the article by Raynauld et al

Fernández-Cuadros, Marcos Edgar

doi:10.1002/acr.23313

Cited by 3 publications

(5 citation statements)

References 8 publications

(9 reference statements)

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“…Firstly, Fernandez-Cuadros et al demonstrated that four intra articular infiltrations of ozone (O 2 -O 3 ) were capable of improving clinical parameters; these were pain, function, stiffness, and quality of life in 119 knee OA patients. The improvement reported in the mid-term followup (two months after treatment) was significant (P < 0.001) (8).…”

Section: Argumentsmentioning

confidence: 78%

“…The DMDOA effect may modify the natural history of knee OA and therefore delay knee arthroplasty replacement. The SYSADOA (6,8)…”

Section: Argumentsmentioning

confidence: 99%

“…None of the recommendations suggested intra articular infiltration of ozone (O 2 -O 3 ) (8). Similarly, the European clinical practice guidelines for the management of knee OA does not include ozone (O 2 -O 3 ) therapy (8).…”

Section: Introductionmentioning

confidence: 99%

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Ozone (O2 - O3) Has SYSADOA (Symptomatic Slow Acting Drug for Osteoarthritis) and DMDOA (Disease Modifying Drug for Osteoarthritis) Effect in Knee Osteoarthritis Patients

Fernández-Cuadros

Albaladejo-Florín

Pérez-Moro

et al. 2019

Middle East J Rehabil Health Stud

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Section: Argumentsmentioning

confidence: 78%

“…The DMDOA effect may modify the natural history of knee OA and therefore delay knee arthroplasty replacement. The SYSADOA (6,8)…”

Section: Argumentsmentioning

confidence: 99%

See 1 more Smart Citation

Ozone (O2 - O3) Has SYSADOA (Symptomatic Slow Acting Drug for Osteoarthritis) and DMDOA (Disease Modifying Drug for Osteoarthritis) Effect in Knee Osteoarthritis Patients

Fernández-Cuadros

Albaladejo-Florín

Pérez-Moro

et al. 2019

Middle East J Rehabil Health Stud

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“…На ранних стадиях остеоартроза (ОА) хрящевые структуры еще способны к самоограничению деструкции [8]. Однако через определенный период времени процесс разрушения хряща становится необратимым, резко ограничивается синтез нормального коллагена и протеогликанов, гипоксия суставных и параартикулярных тканей возрастает [6,[8][9][10][11][12].…”

Section: обоснованиеunclassified

The use of the functional state of the joints for the estimation of the effectiveness of the application of oxygen/ozone therapy for the rehabilitative treatment of the patients suffering from knee arthritis

Baranova

2018

Vopr. kurortol. fizioter. lech. fiz. kul't.

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The present study has demonstrated the expediency and effectiveness of the application of oxygen/ozone therapy during exacerbation of stage І-ІІ knee arthritis as evaluated based on the WOMAC index, VAS, and Lyshom scale within one and six months after the onset of the treatment. The resulting reduction in the number of days of temporary incapacity for work in the patients suffering from knee arthritis gives evidence of the clinical and economic validity of the proposed method of the combined treatment of this condition based on the application of oxygen/ozone therapy.

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“…The definitive surgical treatment includes total replacement arthroplasty, which has a success rate of 95% at 10 years, although this technique is not free of risks and complications [2]. Controversy exists regarding the symptomatic and disease-modifying effect of conservative treatments, such as chondroitin sulfate/glucosamine [3,4].…”

Section: Introductionmentioning

confidence: 99%

Symptomatic (Pain and Inflammation) and Disease-Modifying Effect (Minimal Joint Space) of Intra-articular Ozone (O2-O3) in Osteoarthritis of the Knee: a Clinical Case

Fernández-Cuadros

Pérez-Moro

Albaladejo-Florín

et al. 2019

SN Compr. Clin. Med.

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The objective of the clinical case is to report the symptomatic effect and, for the first time, the disease-modifying effect of ozone in a patient with osteoarthritis of the knee. A 67-year-old woman has been infiltrated with ozone 1 time/week for 4 weeks, using an oxygen-ozone volume of 20 ml, at a 20-µg/ml concentration. Another cycle of ozone treatment was boosted at 6 months follow-up. Clinical outcomes such as pain, function, and quality of life were measured by the Western Ontario and McMaster University Index for Osteoarthritis (WOMAC) scale. Biochemical markers of inflammation such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and uric acid were performed at the beginning and at the end of ozone (O2-O3) treatment protocol. Radiological outcome was evaluated as the change in minimal joint space at the medial compartment of joint space, at the beginning and at 12 months follow-up in both knees. In the first and second ozone cycles, clinical (pain, function, rigidity) and biochemical variables (CRP, ESR, uric acid) improved in our case report. Minimal joint space at medial compartment improved in both knees after 12 months follow-up. Intra-articular ozone (O2-O3) has shown a symptomatic effect and especially a disease-modifying effect in a patient with knee osteoarthritis, improving pain, function, and rigidity; decreasing inflammation biomarkers (CRP, ESR, and uric acid); and increasing the joint space of the medial component evidenced radiologically. The structural effect is reported for the first time in literature. No adverse effects have been observed after intra-articular ozone infiltrations.

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Does glucosamine/chondroitin sulfate have a long‐term effect on the progression of structural changes in knee osteoarthritis? Comment on the article by Raynauld et al

Cited by 3 publications

References 8 publications

Ozone (O2 - O3) Has SYSADOA (Symptomatic Slow Acting Drug for Osteoarthritis) and DMDOA (Disease Modifying Drug for Osteoarthritis) Effect in Knee Osteoarthritis Patients

Ozone (O2 - O3) Has SYSADOA (Symptomatic Slow Acting Drug for Osteoarthritis) and DMDOA (Disease Modifying Drug for Osteoarthritis) Effect in Knee Osteoarthritis Patients

The use of the functional state of the joints for the estimation of the effectiveness of the application of oxygen/ozone therapy for the rehabilitative treatment of the patients suffering from knee arthritis

Symptomatic (Pain and Inflammation) and Disease-Modifying Effect (Minimal Joint Space) of Intra-articular Ozone (O2-O3) in Osteoarthritis of the Knee: a Clinical Case

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