Factors affecting antipyrine metabolism in West African villagers

Abstract

Saliva half-life of antipyrine was studied in 49 healthy Gambians between 20 and 60 yr of age of whom 27 were male (mean age, 44.5) and 22 female (mean age, 39.1). Body wieght, height, ponderal index, albumin, and hemoglobin were moderately reduced compared to accepted normal values. Antipyrine half-life was 13.6 +/- 0.58 (SEM) hr. Multiple regression analysis showed that sex, cola nut consumption, hemoglobin in women, and height in men were statiscally significant independent predictors of antipyrine half-life. Half-life was shorter in women, decreased with an increase in height in men, and was prolonged by cola nut consumption. Half-life in women increased with hemoglobin. These factors explained 36% of the variation and suggest that geographic differences in the environment could be important in drug metabolism in man.

Diazepam and N‐desmethyldiazepam concentrations in saliva, plasma and CSF.

“…The correlation of 0.81 between nordiazepam saliva and plasma diazepam would however, make a knowledge of the salivary concentrations of these drugs of sufficient validity to be of value in epidemiological studies (Fraser, Bulpitt, Kahn, Mould, Mucklow & Dollery, 1976).…”

Environmental factors affecting antipyrine metabolism in London factory and office workers.

“…Within the sample there were two distinct sub-groups whose different cultures resulted in differences in a number of the environmental factors being investigated. The majority of subjects of Asian origin had retained traditional social customs which resembled more closely those of the Gambian villagers first studied (Fraser, Bulpitt et al, 1976). Thus alcohol was taken by a minority (males only) and cigarettes and the contraceptive pill were rarely used.…”

Oral absorption and secretion of drugs.

“…Antipyrine metabolism was assessed in West African villagers, despite adverse study conditions, by obtaining saliva instead of blood samples (Fraser, Bulpitt, Kahn, Mould, Mucklow & Dollery, 1976). Measurement of drug concentrations, in mixed saliva can be inaccurate however as it is a fluid of variable content.…”