Environmental factors affecting antipyrine metabolism in London factory and office workers.

Self Cite

1 Antipyrine clearance has been measured using saliva samples in 50 Maharashtrans from a village to the north of Bombay. 2 All subjects were very lean and were also anaemic probably as a result of hookworm infestation. 3 Antipyrine clearance was 36% faster than in White Londoners studied previously and more than twice as fast as in Asian immigrants living in London. 4 Clearance was 25% faster in men than in women but volume of distribution was also greater in men and mean half-lives did not differ significantly between the sexes. 5 There was a negative correlation between antipyrine clearance and haemoglobin concentration. 6 The study has identified geographic differences in antipyrine metabolism which could be clinically important. The role of anaemia merits further study.

mentioning

confidence: 99%

Antipyrene clearance in Indian villagers.

Desai¹,

Sheth²,

Mucklow³

et al. 1980

Self Cite

“…The determination of blood group and red cell enzyme phenotypes revealed no unexpected variation within the sample, but the small numbers involved made it impossible to infer genetic homogeneity with great confidence. The small number of smokers in the sample and the inexcessive consumption of alcohol and caffeinecontaining beverages resembled the pattern of social habits found in the Indo-Pakistani immigrants studied previously in London (Fraser et al, 1979). It therefore proved possible to examine the effect of dietary variables independent of many other environmental factors.…”

Section: Discussionmentioning

confidence: 66%

“…Forty-eight of the 56 Indo-Pakistani immigrants studied in London (Fraser et al, 1979) were lactovegetarian and antipyrine clearance values lay in the range 0.2-0.7 ml min-' kg-'. Only three of the 16 lactovegetarians studied in Newcastle had values which lay outside this range although the mean (+ s.e.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The relationship between individual dietary constituents and antipyrine metabolism in Indo‐Pakistani immigrants to Britain.

Mucklow¹,

Caraher²,

Henderson³

et al. 1982

Self Cite

1 Antipyrine clearance has been measured from serial saliva samples in 36 healthy adult IndoPakistani immigrants to Britain, to assess the effect of dietary differences within this population. 2 Clearance (mean + s.e. mean) was significantly slower in 16 lactovegetarians (0.54 + 0.06 ml min-m kg-') than in the subjects who ate meat regularly (0.91 + 0.07 ml min-m kg-1). 3 The absence of meat from the diet was associated with a significantly smaller daily intake of dietary protein, which was abnormally low by Western standards. 4 It is likely that the contrast in daily protein intake between the dietary subgroups was largely responsible for the differences observed in antipyrine clearance.

“…Some studies have shown that both OCS preparations and environmental factors, such as smoking and diet, may affect antipyrine elimination (Fraser et al, 1977(Fraser et al, , 1979. These studies involved measurement of antipyrine in saliva but did not specify the OCS used.…”

Section: Antipyrine Eliminationmentioning

confidence: 99%

Antipyrine elimination in saliva after low‐dose combined or progestogen‐ only oral contraceptive steroids.

Chambers¹,

Jefferson²,

Chambers³

et al. 1982

1 A ‘low‐dose’ combined oral contraceptive steroid (OCS) preparation containing 30 microgram ethinylo‐estradiol and 150 microgram levonorgestrel was found to reduce significantly antipyrine clearance in a group of women acting as their own controls. 2 An OCS preparation containing only a progestogen (75 microgram norgestrel) did not reduce antipyrine clearance in a second group of women. 3 The evidence suggesting that the oestrogen component of combined OCS preparations could be responsible for the reduction in antipyrine clearance is discussed.