2018
DOI: 10.1166/jbn.2018.2485
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Facile Optimization and Evaluation of PEG–PCL Block Copolymeric Nanoparticles for Anticancer Drug Delivery Using Copolymer Hybrids and Histoculture Drug Response Assays

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Cited by 7 publications
(12 citation statements)
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“…In order to overcome the disadvantages (solubility and degradation), many researchers are studying to improve the efficacy and effectiveness of the drug by using a drug delivery system ( 37 , 38 ). Among many drug delivery systems, polymers that synthesize biodegradable polyesters have been applied for many years ( 39 41 ), nanoparticles composed of hydrophobic poly (ε-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) among several polymers ( 42 , 43 ) have been reported to be good potential carriers for anti-cancer agents ( 39 , 44 ). PCL is a biodegradable, biocompatible, hydrophobic and non-toxic thermoplastic polyester ( 45 ).…”
Section: Introductionmentioning
confidence: 99%
“…In order to overcome the disadvantages (solubility and degradation), many researchers are studying to improve the efficacy and effectiveness of the drug by using a drug delivery system ( 37 , 38 ). Among many drug delivery systems, polymers that synthesize biodegradable polyesters have been applied for many years ( 39 41 ), nanoparticles composed of hydrophobic poly (ε-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) among several polymers ( 42 , 43 ) have been reported to be good potential carriers for anti-cancer agents ( 39 , 44 ). PCL is a biodegradable, biocompatible, hydrophobic and non-toxic thermoplastic polyester ( 45 ).…”
Section: Introductionmentioning
confidence: 99%
“…Traditional chemotherapy has long been limited due to drug resistance and PLGA, poly(lactic-co-glycolic acid); PCL, polycaprolactone; NIR, near infrared ray; BMP, bone morphogenetic protein; FGF, fibroblast growth factor; IGF, insulin-like growth factor; IL-4, interleukin-4; TGF-β, transforming growth factor-β the severe side effects caused by the off-target toxicity of drugs. Fortunately, nanomaterials 44,45 act as precise regulators for the control and release of chemotherapeutic drugs and not only maximize the accuracy of targeting tumour cells but also reduce the adverse reactions caused by drug leakage. DTX 46 is a commonly applied anticancer drug that inhibits physiological microtubule depolymerization and disassembly, but its poor water solubility has restricted its application.…”
Section: Biomaterials-mediated Chemotherapymentioning
confidence: 99%
“…Predetermined amount of CDDP and Tet-loaded nanoparticles were prepared by double emulsion (DE) method [14,18]. CDDP and Tet was emulsified with 1 mL of dichloromethane (DCM) solution containing 5 mg of mPEG-PCL and 15 mg of HO-PCL, by sonication for 15 s (15 W) in an ice bath (solution W1).…”
Section: Preparation Of Cddp-tet-loaded Nanoparticlesmentioning
confidence: 99%
“…Preliminarily, we have managed to construct CDDPloaded NPs [14,15] and Tet-loaded NPs using polyethylene glycol-poly(caprolactone) (PCL-PEG) [16], whose in vivo antitumor effects have both been demonstrated. In this study, we used PEG-PCL for the co-delivery of CDDP and Tet.…”
Section: Introductionmentioning
confidence: 99%
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