Facile Fabrication of Polysaccharide Nanocomposites Using Ionic Gelation Method

Abstract

Polysaccharide-based nanomaterials with significant biocompatibility and physiochemical features have been widely analyzed in modern biomedical nanotechnology. Chitosan-coating is an advantageous procedure to provide several pharmacological characteristics of chitosan on the reinforcement. Here, we fabricated polysaccharide nanocomposites using the facile ionic gelation method and sodium tripolyphosphate (TPP) cross-linker. The polysaccharide nanocomposites comprised natural cellulose and chitosan as reinforcement and coating agents, respectively. From the image of the scanning electron microscope, the nanocomposites indicated almost spherical dimensions with sizes below 60 nm. Results from X-ray powder diffraction and Fourier-transform infrared spectroscopy showed multifunctional properties of the nanocomposites related to both cellulose and chitosan. Therefore, the ionic gelation method is potentially appropriate to synthesize the polysaccharide nanocomposites for medically-related applications.

Synthesis and Characterization of Ionically Cross-Linked Chitosan Nanoparticles

“…Numerous natural and synthetic polymers, such as chitosan and polyethyleneimine (PEI), have been used to manufacture nanoparticles that can transport DNA/siRNA or anticancer drugs [3]. With an annual production of more than 100 million tonnes [4], chitosan ranks as the second most prevalent polysaccharide on the planet [5]. It is a copolymer that contains -(1,4)-2-acetamido-D-glucose and -(1,4)-2-amino-D-glucose unit (Figure 1), chitosan is prepared by removing an acetate moiety from chitin through hydration in concentrated alkali [6].…”

Isotherm Behaviour of P3OT, P3HT and PCBM Langmuir Layer on Ionic Subphase

“…It is a well-known method used to produce a monolayer or multilayer film using floating molecules and is highly dependent on the surface pressure [3]. The multilayer of Langmuir's film differs from multilayers produced by other techniques, such as the ion gelation technique [4].…”