Facile fabrication of hypercrosslinked microporous polymer nanospheres for effective inhibition of triple negative breast cancer cells proliferation

Razzaque, Shumaila; Guo, Lijuan; Weng, Jun; Su, Li; Tan, Bien

doi:10.1016/j.jcis.2022.03.109

Cited by 5 publications

(4 citation statements)

References 51 publications

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“…In this manner, functionalized hyper-crosslinked microporous organic nanospheres, named HMPNs-EDA-ssDNA (Figure 10A,B), were developed, which showed strong blue fluorescence. 121 The cellular uptake of the functionalized nanospheres (HMPNs, HMPNs-EDA, and HMPNs-EDA-ssDNA) in different cell types (HEK293, SUM-159, and HeLa) was tested by bioimaging using confocal laser scanning microscopy. After adding the HMPNs, a clear blue fluorescence was observed inside the cells, indicating successful internalization.…”

Section: Bioimagingmentioning

confidence: 99%

“…For bioimaging purposes, the fluorescence molecule is powerful to visualize particular cells due to their emission properties in response to the specific wavelength of light. In this manner, functionalized hyper‐crosslinked microporous organic nanospheres, named HMPNs‐EDA‐ssDNA (Figure 10A,B), were developed, which showed strong blue fluorescence 121 . The cellular uptake of the functionalized nanospheres (HMPNs, HMPNs‐EDA, and HMPNs‐EDA‐ssDNA) in different cell types (HEK293, SUM‐159, and HeLa) was tested by bioimaging using confocal laser scanning microscopy.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

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Rational design of hyper‐crosslinked polymers for biomedical applications

Qian

Kim

Tang

et al. 2023

Journal of Polymer Science

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Hyper‐crosslinked polymers (HCPs) are a family of polymers that possess several desirable characteristics, including high specific surface area, excellent stability, tunable porous structures, and low‐cost reagents. As a result, HCPs have gained significant attention in the areas of gas storage, adsorption, catalysis, separation, and carbon precursors, exhibiting advanced performances in catalytic and energy‐related applications. Recently, researchers have explored the potential of HCPs in biomedical engineering. In this review, we discuss classical synthesis strategies and morphological assembly methods used to create HCPs with unique biological properties. We also highlight the latest advances in emerging biomedical areas of HCPs, such as drug delivery, antimicrobial, bioimaging, and biosensing. By providing various examples, we further discuss the correlations between the structures, morphologies, and enhanced biomedical properties of the HCPs. Finally, we summarize the key applications of HCPs and provide an outlook on the research direction to encourage further development of biomedically available HCPs. Overall, HCPs offer promising potential as a new class of materials for use in biomedical applications, and continued research in this field will lead to exciting discoveries and breakthroughs.

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Section: Bioimagingmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

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Rational design of hyper‐crosslinked polymers for biomedical applications

Qian

Kim

Tang

et al. 2023

Journal of Polymer Science

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“…HCP is characterized by simple synthesis methods, low cost, a wide choice of monomers, high yields, and easy post-modification [ 20 , 21 ]. Due to their relatively stable porous structure and resistance to collapse, HCPs have been widely used in catalysis [ 22 , 23 ], adsorption [ 24 ], sensing [ 25 , 26 ], drug delivery [ 27 , 28 ], gas storage [ 29 ], and other fields [ 30 , 31 , 32 ]. To date, there are already reports on the comprehensive review of the applications of hyper-crosslinked polymers (HCPs) in areas such as biomedical applications [ 33 ], removal of heavy metal ions [ 34 ], and dye adsorption [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Hyper-Crosslinked Porous Organic Nanomaterials: Structure-Oriented Design and Catalytic Applications

Luo,

Mei,

et al. 2023

Nanomaterials

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Hyper-crosslinked porous organic nanomaterials, especially the hyper-crosslinked polymers (HCPs), are a unique class of materials that combine the benefits of high surface area, porous structure, and good chemical and thermal stability all rolled into one. A wide range of synthetic methods offer an enormous variety of HCPs with different pore structures and morphologies, which has allowed HCPs to be developed for gas adsorption and separations, chemical adsorption and encapsulation, and heterogeneous catalysis. Here, we present a systematic review of recent approaches to pore size modulation and morphological tailoring of HCPs and their applications to catalysis. We mainly compare the effects of pore size modulation and morphological tailoring on catalytic applications, aiming to pave the way for researchers to develop HCPs with an optimal performance for modern applications.

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