2023
DOI: 10.1002/pol.20230270
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Rational design of hyper‐crosslinked polymers for biomedical applications

Abstract: Hyper‐crosslinked polymers (HCPs) are a family of polymers that possess several desirable characteristics, including high specific surface area, excellent stability, tunable porous structures, and low‐cost reagents. As a result, HCPs have gained significant attention in the areas of gas storage, adsorption, catalysis, separation, and carbon precursors, exhibiting advanced performances in catalytic and energy‐related applications. Recently, researchers have explored the potential of HCPs in biomedical engineeri… Show more

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Cited by 33 publications
(21 citation statements)
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References 143 publications
(240 reference statements)
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“…The novel approach for the preparation of HCPs expands the range of monomer options, increases the surface area and enriches the micropores. Topuz et al 91 turned a cyclodextrin solution into nanofibers by electrospinning, a commonly used method for preparing fibers, [92][93][94][95][96][97] followed by cross-linking with graphitic acid to produce a polymer network (Fig. 7a), and the nanofibers were subsequently crosslinked.…”
Section: Yaozu Liaomentioning
confidence: 99%
“…The novel approach for the preparation of HCPs expands the range of monomer options, increases the surface area and enriches the micropores. Topuz et al 91 turned a cyclodextrin solution into nanofibers by electrospinning, a commonly used method for preparing fibers, [92][93][94][95][96][97] followed by cross-linking with graphitic acid to produce a polymer network (Fig. 7a), and the nanofibers were subsequently crosslinked.…”
Section: Yaozu Liaomentioning
confidence: 99%
“…In short, multi-fluid electrospinning, exemplified by triaxial electrospinning, allows for precise control over the layer thickness or drug-loaded fiber attributes. This control is achieved by manipulating the flow type, flow rate ratio, or fluid concentrations of different working fluids, resulting in tailored, specific drug release performance [ 54 , 55 , 56 , 57 ].…”
Section: Preparation Of Drug-loaded Nanofibers Via Electrospinningmentioning
confidence: 99%
“…Hyper-crosslinked polymers (HCPs) are useful MOP materials commonly obtained with high stability and porosity under mild reaction conditions. 38–41 Recently, we developed a unique Lewis acid–base interaction-mediated self-assembly method that allowed the in situ formation of hollow spherical HCPs with hydroxyl functionality. 42,43 Specifically, the one-pot Friedel–Crafts self-crosslinking reaction using 1,4-benzenedimethanol as the monomer and iron chloride as the catalyst enabled the formation of HCPs characterised by inner hollow structures and outer needle-shaped spheres, resembling sea urchins.…”
Section: Introductionmentioning
confidence: 99%