Facile fabrication of fluorescent Fe-doped carbon quantum dots for dopamine sensing and bioimaging application

Zhuo, Shujuan; Guan, Yuanyuan; Li, Hui; Fang, Jing; Zhang, Ping; Du, Jinyan; Zhu, Changqing

doi:10.1039/c8an01741g

Cited by 81 publications

(39 citation statements)

References 40 publications

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“…Finally, since it is important to quantify the concentration of DA in the body fluid to assess the physiological condition, the nanoprobe was applied in the determination of DA in complex fluids, simulated body fluid (SBF) and urine sample, spiked with different concentrations of DA using standard addition method . From the results, shown in Table S1 (Supporting Information), it can be clearly observed that the probe showed good recovery values between the spiked and the detected concentration, indicating the probe is capable of detecting the DA in a reliable manner.…”

Section: Resultsmentioning

confidence: 99%

Upconversion Nanoplatform for FRET‐Based Sensing of Dopamine and pH

2019

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Dopamine (DA) plays a very critical role in controlling the key functionalities, such as in metabolic, memory and behavioural aspects. The deviation from the normal range of concentration has been linked to serious neurological disorders and cancers. Therefore, development of a facile sensing platform with a prospective potential to be applied in the real‐time analysis of DA in vivo holds a great promise. To achieve this, an upconversion nanoparticle (UCNP) based nanoplatform with mesoporous silica functionality (BSCU‐MS) has been proposed as an efficient DA sensing probe. The UCNP has been tuned to exhibit emission in particular region with high PL intensity that could be selectively absorbed by the DA in quinone form (q‐DA) through Förster resonance energy transfer (FRET) mechanism. We showed that the proposed nanoplatforms are capable of detecting DA in a sensitive and very selective manner with the limit of detection (LOD) as 0.63 nM (with S/N=3). Also, owing to the interesting electronic behaviour of DA to undergo pH‐dependent oxidation and reduction process, we also demonstrate the applicability of DA loaded BCSU‐MS for fluorescence‐based pH sensing. We propose that the method described offers a very promising and efficient strategy for the detection of DA‐related diseases and the ensuing physiological pH changes.

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Section: Resultsmentioning

confidence: 99%

Upconversion Nanoplatform for FRET‐Based Sensing of Dopamine and pH

2019

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“…The replacement of the main carbon backbone by a soft element e.g., S (Yang et al, 2016 ; Yao et al, 2019 ), Se (Yang et al, 2014 ), N (Jiang et al, 2015b ; Chen et al, 2016 ; Carolan et al, 2017 ; He S. et al, 2018 ; Yao et al, 2019 ), P (Venkateswara Raju et al, 2020 ), B (Wei et al, 2020 ), or both N and S (Zhang et al, 2018 ), and a hard element e.g., Fe (Zhuo S. et al, 2019 ) and Ag (Zhuo S. J. et al, 2019 ) results in the formation of a doped CQD. For example, Raju et al, autoclaved tri-sodium citrate in the presence of phosphoric acid at 180°C for 12 h resulting in the formation of a p–doped CQD, which was further used to detect Cu 2+ ions (Venkateswara Raju et al, 2020 ).…”

Section: Photophysics Of Carbon Quantum Dotsmentioning

confidence: 99%

A Perspective on Application of Carbon Quantum Dots in Luminescence Immunoassays

Hesari

Ding

2020

Front. Chem.

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“…Recently, several other publications reported the facile fabrication of Fe (II) [17,18] or Fe (III) doped C-dots [19] by the hydrothermal method. The as-synthesized Fe ions doped C-dots showed bright blue fluorescence and good biocompatibility that can be successfully used for bioimaging.…”

Section: Introductionmentioning

confidence: 99%

Bifunctional Carbon Dots—Magnetic and Fluorescent Hybrid Nanoparticles for Diagnostic Applications

et al. 2020

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There is a huge demand for materials capable of simple detection or separation after conjugation with specific biologic substances when applied as a diagnostic tools. Taking into account the photoluminescence properties of C-dots and the highly magnetic properties of Fe(0), a new hybrid composite of these components was synthesized via ultrasound irradiation. The material was fully characterized by various physicochemical techniques. The main goal of the current study was to obtain a highly magnetic and intense fluorescent hybrid material. The goal was achieved. In addition, magnetic particles tended to agglomerate. The new hybrid can be suspended in ethanol, which is an additional feature of the current research. The dispersion of the hybrid nanoparticles in ethanol was achieved by utilizing the interaction of iron particles with C-dots which were decorated with functional groups on their surface. The newly formed hybrid material has potential applications in diagnostic by conjugating with specific antibodies or with any other biologic compounds. Such application may be useful in detection of various diseases such as: cancer, tuberculosis, etc.

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Facile fabrication of fluorescent Fe-doped carbon quantum dots for dopamine sensing and bioimaging application

Abstract: A facile Fe-doped carbon quantum dot based fluorescent sensor for dopamine sensing and bioimaging was constructed.

Cited by 81 publications

References 40 publications

Upconversion Nanoplatform for FRET‐Based Sensing of Dopamine and pH

Upconversion Nanoplatform for FRET‐Based Sensing of Dopamine and pH

A Perspective on Application of Carbon Quantum Dots in Luminescence Immunoassays

Bifunctional Carbon Dots—Magnetic and Fluorescent Hybrid Nanoparticles for Diagnostic Applications

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