Upconversion Nanoplatform for FRET‐Based Sensing of Dopamine and pH

Abstract

Dopamine (DA) plays a very critical role in controlling the key functionalities, such as in metabolic, memory and behavioural aspects. The deviation from the normal range of concentration has been linked to serious neurological disorders and cancers. Therefore, development of a facile sensing platform with a prospective potential to be applied in the real‐time analysis of DA in vivo holds a great promise. To achieve this, an upconversion nanoparticle (UCNP) based nanoplatform with mesoporous silica functionality (BSCU‐MS) has been proposed as an efficient DA sensing probe. The UCNP has been tuned to exhibit emission in particular region with high PL intensity that could be selectively absorbed by the DA in quinone form (q‐DA) through Förster resonance energy transfer (FRET) mechanism. We showed that the proposed nanoplatforms are capable of detecting DA in a sensitive and very selective manner with the limit of detection (LOD) as 0.63 nM (with S/N=3). Also, owing to the interesting electronic behaviour of DA to undergo pH‐dependent oxidation and reduction process, we also demonstrate the applicability of DA loaded BCSU‐MS for fluorescence‐based pH sensing. We propose that the method described offers a very promising and efficient strategy for the detection of DA‐related diseases and the ensuing physiological pH changes.

Facile transdermal delivery of upconversion nanoparticle by iontophoresis-responsive magneto-upconversion oleogel

“…The purpose of such selection was to avoid the quenching of NIR induced green emission (λmax=500 to 540 nm) from NaYF 4 : Yb 3+ / Er 3+ based UCNP by Fe 3 O 4 nanoparticles [21]. The Tm 3+ based blue-emitting UCNP synthesized here as already been reported for extensive theranostic applications [22]. The target of our synthetic method was to generate oleylamine coated blue-emitting UCNP, so that the particles can be readily dispersed in organic or lipophilic phase.…”

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

“…Furthermore, the authors immobilized the nanoparticles by a simple impregnation procedure, obtaining paper-based test strips capable of detecting dopamine in human serum at nM concentrations. Besides the aforementioned nanoparticle and also other hard matter-based nanoparticles such as upconverting nanoparticles ( N4.16–N4.19 ), − carbon dots ( N4.120 – N4.23 ), − quantum dots ( N4.24 – N4.28 ), − silicon nanoparticles ( N4.29 ), metal–organic frameworks ( N4.30 ), and silica-based nanoparticles ( N4.31 – N4.33 ) − have been reported for sensing of neurotransmitters.…”

Synchrotron-Based X-ray Analysis: Relating Compressive Lattice Strain with the Photoluminescence Intensity of Li+-Doped β-NaYF4:Yb3+/Ln3+ (Ln3+ = Ho3+/Er3+/Tm3+) Upconversion Crystals

“…In the context of lattice structure dictating optical properties, the development of NIR-responsive photoluminescent upconversion (UC) materials and its application in biomedicine, display devices, photocatalysis, solar cells, etc. constitute important current research topics. − Since the success of these UC materials in their respective fields of application is critically dependent on the intensities of the corresponding upconversion luminescence (UCL), considerable research has been devoted to generate brighter UC materials with a purpose to understand the fundamental basis or mechanism of the enhanced UCL intensity. − …”