Fabrication of Zn-Sr–doped laser-spinning glass nanofibers with antibacterial properties

Abstract

The morphology and dimensions of bioactive materials are essential attributes to promote tissue culture. Bioactive materials with nanofibrous structure have excellent potential to be used as bone-defect fillers, since they mimic the collagen in the extracellular matrix. On the other hand, bioactive glasses with applications in regenerative medicine may present antibacterial properties, which depend on glass composition, concentration and the microorganisms tested. Likewise, their morphology may influence their antibacterial activity too. In the present work, the laser-spinning technique was used to produce bioactive glass nanofibers of two different compositions: 45S5 Bioglass® and ICIE16M, bioactive glass doped with zinc and strontium. Their antibacterial activity against Staphylococcus aureus was tested by culturing them in dynamic conditions. Bacterial growth index profiles during the first days of experiment can be explained by the variations in the pH values of the media. The bactericidal effect of the doped nanofibers at longer times is justified by the release of zinc and strontium ions. Cytotoxicity was analyzed by means of cell viability tests performed with BALB/3T3 cell line.

Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass

“…Sodium alginate was obtained from Fisher Scientific Ltd (Leicestershire, UK), while calcium chloride and sodium lauryl sulphate were obtained from Sigma-Aldrich Ltd (Gillingham, UK). ICIE16M glass powder, which is a modification of ICIE16 (see Table 1), was synthesized as in previous protocols [52,53,54]. Compositions for ICIE16 and ICIE16M are given in Table 1.…”

“…The composite is made by combining an alginate with strontium (Sr) and zinc (Zn) containing bioactive glass ICIE16M. The ICIE16M is modified from ICIE16 [52,53]. The glass ICIE16 has bioactivity comparable to 45S5, but large sintering window.…”

“…The glass ICIE16 has bioactivity comparable to 45S5, but large sintering window. In their study, Echezarreta-López et al [52] showed the release of Sr and Zn ions from the ICIE16M glass. The presence of strontium and zinc in ICIE16M has a beneficial effect on bone growth [54,55].…”

Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy

“…In the paper of Jones, the author nicely describes Bioglass ® history from its discovery, Bioglass ® advantages, the material’s osteoconduction and osteoinduction properties, and introduces new bioglass composite hybrid materials. Composites with increased stiffness and mechanical properties are obtained by blending bioglass particles with biodegradable polymers such as the well-known PLA, polyglycolic acid (PGA), PLGA, and PCL, whose characteristics are reported in Section 2.2 [ 64 , 65 , 66 , 67 , 68 , 69 ].…”

Polyacrylonitrile nanofiber mats containing titania/AgNP composite nanoparticles for antibacterial applications

“…Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. (Naghashzargar et al 2015, Yin et al 2016, Echezarreta-López et al 2017, Murugan et al 2017. To produce antimicrobial activities and protect from harmful microorganisms such as bacteria, viruses and fungus, the nanofiberous films need a suitable antimicrobial agent.…”