Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy

Dorati, Rossella; DeTrizio, Antonella; Modena, Tiziana; Conti, Bice; Benazzo, Francesco; Gastaldi, Giulia; Genta, Ida

doi:10.3390/ph10040096

Cited by 132 publications

(137 citation statements)

References 118 publications

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“…Improvement of the manufacturing processes, which eliminate structural flaws (Tiainen, Wiedmer, & Haugen, ) or improve microstructural features (Georgiou & Knowles, ; De Aza, Chevalier, Fantozzi, Schehl, & Torrecillas, ) or composite structures (Miao, Tan, Li, Xiao, & Crawford, ; Novak, Druce, Chen, & Boccaccini, ), is alternatives in improving the intrinsic strength of synthetic bioceramics. The most investigated CaP BG substitutes are hydroxyapatite, beta‐tricalcium phosphate and their combination, also called biphasic calcium phosphate (Dorati et al., ). Synthetic bioceramics have demonstrated the ability to partially integrate into natural bone tissue and stimulate osteoblast differentiation, osteoblast growth and inorganic matrix deposition.…”

Section: Review Of Current Literaturementioning

confidence: 99%

Bone grafts: which is the ideal biomaterial?

Haugen

Lyngstadaas

Rossi

et al. 2019

J Clinic Periodontology

398

353

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Bovine xenograft materials, followed by synthetic biomaterials, which unfortunately still lack documented predictability and clinical performance, dominate the market for the cranio‐maxillofacial area. In Europe, new stringent regulations are expected to further limit the allograft market in the future. Aim Within this narrative review, we discuss possible future biomaterials for bone replacement. Scientific Rationale for Study Although the bone graft (BG) literature is overflooded, only a handful of new BG substitutes are clinically available. Laboratory studies tend to focus on advanced production methods and novel biomaterial features, which can be costly to produce. Practical Implications In this review, we ask why such a limited number of BGs are clinically available when compared to extensive laboratory studies. We also discuss what features are needed for an ideal BG. Results We have identified the key properties of current bone substitutes and have provided important information to guide clinical decision‐making and generate new perspectives on bone substitutes. Our results indicated that different mechanical and biological properties are needed despite each having a broad spectrum of variations. Conclusions We foresee bone replacement composite materials with higher levels of bioactivity, providing an appropriate balance between bioabsorption and volume maintenance for achieving ideal bone remodelling.

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Section: Review Of Current Literaturementioning

confidence: 99%

Bone grafts: which is the ideal biomaterial?

Haugen

Lyngstadaas

Rossi

et al. 2019

J Clinic Periodontology

398

353

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“…Unfortunately, these sophisticated approaches were not completely able to overcome biofilm's adaptive abilities. One not so sophisticated but the effective strategy of bone biofilm eradication is the application of a high local concentration of antibiotic coupled with carriers such as chitosan, hyaluronic acid, or collagen . Choice of an antimicrobial appropriate carrier is thus paramount.…”

Section: Introductionmentioning

confidence: 99%

“…One not so sophisticated but the effective strategy of bone biofilm eradication is the application of a high local concentration of antibiotic coupled with carriers such as chitosan, hyaluronic acid, or collagen. 5 Choice of an antimicrobial appropriate carrier is thus paramount. A carrier suitable to be applied against biofilm-based infection should be of low or zero cytotoxicity against the host's cells and should release high concentrations of antimicrobial (during first day after the surgical procedure).…”

Section: Introductionmentioning

confidence: 99%

Application of bacterial cellulose experimental dressings saturated with gentamycin for management of bone biofilm in vitro and ex vivo

et al. 2019

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Bacterial cellulose is one of the most promising polymers of recent years. Herein, we present a possibility of BC application as a carrier of gentamycin antibiotic for the treatment and prevention of bone infections. We have shown that BC saturated with gentamycin significantly reduces the level of biofilm‐forming bone pathogens, namely Staphylococcus aureus and Pseudomonas aeruginosa, and displays very low cytotoxicity in vitro against osteoblast cell cultures. Another beneficial feature of our prototype dressing is prolonged release of gentamycin, which provides efficient protection from microbial contamination and subsequent infection. Moreover, it seems that bacterial cellulose (BC) alone without any antimicrobial added, may serve as a barrier by significantly hampering the ability of the pathogen to penetrate to the bone structure. Therefore, a gentamycin‐saturated BC dressing may be considered as a possible alternative for gentamycin collagen sponge broadly used in clinical setting. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:30–37, 2020.

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“…It can be implanted into the body as a cell-free scaffold, or it may be already supplied with cells and/or growth factors, cytokines, and genetic material (bioengineered scaffolds). The latter has the advantage by promoting faster tissue regeneration, especially in some pathological conditions, when the tissue does not have inherent self-regenerating potential [10].…”

Section: Review Articlesmentioning

confidence: 99%

“…All these variables (shape, structure, and composition) should be balanced in order to find the combination that perfectly matches with the properties and functions of the damaged bone. This means a significant number of combinations among polymers, minerals, and other materials need to be evaluated [10].…”

Section: Artificial Scaffolds For Bone Tissue Regenerationmentioning

confidence: 99%

Prospectives for using artificial scaffolds in oral and craniofacial surgery: literature review

Yaremenko¹,

Lysenko²,

Ivanova³

et al. 2018

CTT

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Regenerative medicine is an emerging field of biotechnology that combines various aspects of medicine including cell and molecular biology, material science and bioengineering -to regenerate, repair or replace tissues. Bone regeneration is a promising approach in dentistry and is considered an ideal clinical strategy in treating diseases, injuries, and defects of the maxillofacial area. Advances in tissue engineering have resulted in the development of innovative scaffold designs, complemented by the progress made in cell-based therapies. In vitro bone regeneration can be achieved by the combination of stem cells, scaffolds, and bioactive factors. A possible improvement in restoring damaged tissues may be achieved by load-ing the scaffolds with drug substances, as well as genetic material, growth factors or other proteins, promoting the tissue regeneration. This review focuses on different biomaterials currently used in dentistry, as potential scaffolds for bone regeneration when treating bone defects, or in surgical interventions, including characteristics and types of these scaffolds, and a literature review of local antibiotic delivery by combined usage of scaffolds and drug-delivery systems.

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Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy

Cited by 132 publications

References 118 publications

Bone grafts: which is the ideal biomaterial?

Bone grafts: which is the ideal biomaterial?

Application of bacterial cellulose experimental dressings saturated with gentamycin for management of bone biofilm in vitro and ex vivo

Prospectives for using artificial scaffolds in oral and craniofacial surgery: literature review

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