Fabrication of ultrathin polyelectrolyte fibers and their controlled release properties

Chunder, Anindarupa; Sarkar, Sourangsu; Yu, Yan; Zhai, Lei

doi:10.1016/j.colsurfb.2007.03.004

Cited by 104 publications

(65 citation statements)

References 64 publications

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“…In contrast, at elevated temperatures (70 1C) the swelling degree of the fibers reduced from 15 to 2.6-fold. Chunder et al 118 fabricated PAA/PAH electrospun fibers and incorporated methylene blue (MB), a low molecular weight cationic molecule, as a model drug to evaluate release from the fibers. As PAA and PAH are both weak polyelectrolytes, the release of MB could be triggered by adjusting the pH of the medium.…”

Section: Multi Stimuli-responsive Electrospun Fiber Systemsmentioning

confidence: 99%

Stimuli-responsive electrospun fibers and their applications

et al. 2011

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In this critical review, an overview is given on recent advances in the development and application of stimuliresponsive electrospun nanofibers.Please check this proof carefully. Our staff will not read it in detail after you have returned it. Translation errors between word-processor files and typesetting systems can occur so the whole proof needs to be read. Please pay particular attention to: tabulated material; equations; numerical data; figures and graphics; and references. If you have not already indicated the corresponding author(s) please mark their name(s) with an asterisk. Please e-mail a list of corrections or the PDF with electronic notes attached --do not change the text within the PDF file or send a revised manuscript.Please bear in mind that minor layout improvements, e.g. in line breaking, table widths and graphic placement, are routinely applied to the final version.Please note that, in the typefaces we use, an italic vee looks like this: n, and a Greek nu looks like this: n.We will publish articles on the web as soon as possible after receiving your corrections; no late corrections will be made.Please return your final corrections, where possible within 48 hours of receipt, by e-mail to: chemsocrev@rsc.org Reprints-Electronic (PDF) reprints will be provided free of charge to the corresponding author. Enquiries about purchasing paper reprints should be addressed via: http://www.rsc.org/publishing/journals/guidelines/paperreprints/. Costs for reprints are below: Stimuli-responsive electrospun nanofibers are gaining considerable attention as highly versatile tools which offer great potential in the biomedical field. In this critical review, an overview is given on recent advances made in the development and application of stimuli-responsive fibers. The specific features of these electrospun fibers are highlighted and discussed in view of the properties required for the diverse applications. Furthermore, several novel biomedical applications are discussed and the respective advantages and shortcomings inherent to stimuli-responsive electrospun fibers are addressed (136 references).

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Section: Multi Stimuli-responsive Electrospun Fiber Systemsmentioning

confidence: 99%

Stimuli-responsive electrospun fibers and their applications

et al. 2011

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“…A sustained and a temperature controlled drug releasing in PBS solutions was achieved by depositing perfluorosilane coatings and PAA/PNIPAAM multilayers onto the fiber surfaces, respectively. [44] In theory, comprehension and clarification of the relationship between the release profiles and the electrospinning parameters help to select suitable materials, optimize electrospinning process, and thus to improve the consistence between design and manufacturing, reduce the time to market for novel DDS. Since the physical form of the active agent in a dosage form can influence the product performance, it is often necessary to quantify the different solid phases in a system for preparing a robust dosage form.…”

Section: Some Challenges and The Possible Resolutionsmentioning

confidence: 99%

Electrospun nanofiber-based drug delivery systems

Yu¹,

Zhu²,

White³

et al. 2009

Health

154

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Electrospinning is a very simple and versatile process by which polymer nanofibers with diameters ranging from a few nanometers to several micrometers can be produced using an electrostatically driven jet of polymer solution or polymer melt. Significant progress has been made in this process throughout the past few years and electrospinning has advanced its applications in many fields, including pharmaceutics. Electrospun nanofibers show great promise for developing many types of novel drug delivery systems (DDS) due to their special characteristics and the simple but useful and effective top-down fabricating process. The current state of electrospun nanofiber-based DDS is focused on drug-loaded nanofiber preparation from pharmaceutical and biodegradable polymers and different types of DDS. However, there are more opportunities to be exploited from the electrospinning process and the corresponding drug-loaded nanofibers for drug delivery. Additionally, some other related challenges and the possible resolutions are outlined in this review.

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“…Blends of PNIPAM with such biocompatible and biodegradable polymers as Poly(acrylic acid) (PAA) can be easily prepared, which yield PAA polymer matrixes with PNIPAM islands inside. Electrospinning, co-electrospinning and various solution-precipitation methods allow for manufacturing of nanofibers and nanoparticles with embedded or grafted macromolecules [1][2][3][4][5]. In addition, nanofibers and nanoparticles functionalized with drugs attract significant interest in biomedical applications [6], where PNIPAM-like stimuli-responsive materials embedded in the bulk or grafted at the surface may facilitate efficient drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive Polymers in Nanotechnology: Deposition and Possible Effect on Drug Release

Yarin

2008

Math. Model. Nat. Phenom.

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Abstract. Stimuli-responsive polymers result in on-demand regulation of properties and functioning of various nanoscale systems. In particular, they allow stimuli-responsive control of flow rates through membranes and nanofluidic devices with submicron channel sizes. They also allow regulation of drug release from nanoparticles and nanofibers in response to temperature or pH variation in the surrounding medium. In the present work two relevant mathematical models are introduced to address precipitation-driven deposition of surface layers of stimuli-responsive polymers and describe a possible effect of swelling-shrinkage transition of such polymers on drug release.

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Fabrication of ultrathin polyelectrolyte fibers and their controlled release properties

Cited by 104 publications

References 64 publications

Stimuli-responsive electrospun fibers and their applications

Stimuli-responsive electrospun fibers and their applications

Electrospun nanofiber-based drug delivery systems

Stimuli-Responsive Polymers in Nanotechnology: Deposition and Possible Effect on Drug Release

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