Fabrication of topical metered dose film forming sprays for pain management

Ranade, S.V.; Bajaj, Amrita; Londhe, Vaishali; Babul, Najib; Kao, Danny

doi:10.1016/j.ejps.2017.01.004

Cited by 35 publications

(50 citation statements)

References 26 publications

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“…20,[30][31][32][33] The thin film is easy to wash away with water. 20,34 This thin and non-sticky film also increases patient comfort during activities compared to using patches, ointments, gels, etc., because these have a rough and sticky texture when applied. 35,36 The thin film also facilitates the permeation of wound moisture so that the balance can be maintained.…”

Section: Definition and Mechanism Of A Film-forming Spraymentioning

confidence: 99%

“…30,32,33 The average spray angle of MDS is 83.51°. 20 The average leakage rate of an MDS container is 0.01-0.02 %. 30…”

Section: Metered Dose Spraymentioning

confidence: 99%

“…Eudragit S100 also does not cause any skin irritation. 20 In vitro permeability tests showed that Eudragit RS produced a thick film when sprayed on a silicone membrane. This was likely due to the crystallisation of methylphenidate, which may have reduced permeation.…”

Section: Eudragitmentioning

confidence: 99%

“…14 Compared to other topical dosages, sprays offer several advantages such as practical use, low incidence of irritation, sterility of the dosage, excellent coverage of the skin or wound, even distribution of the drug when applied, and adjustable dosage. [14][15][16][17][18][19][20] In recent decades, various innovations have continued to be developed to obtain efficient and effective spray preparations. One of them is a film-forming spray (FFS) which has been applied in multiple fields, such as the food industry, cosmetics, pharmaceuticals, plantations, etc.…”

Section: Introductionmentioning

confidence: 99%

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<p>Film-Forming Sprays for Topical Drug Delivery</p>

Umar¹,

Butarbutar²,

Sriwidodo³

et al. 2020

DDDT

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Film-forming sprays offer many advantages compared to conventional topical preparations because they can provide uniform drug distribution and dose, increased bioavailability, lower incidence of irritation, continuous drug release, and accelerated wound healing through moisture control. Film-forming sprays consist of polymers and excipients that improve the characteristics of preparations and enhance the stability of active substances. Each type of polymer and excipient will produce films with different features. Therefore, the various types of polymers and excipients and their evaluation standards need to be examined for the development of a more optimal form of film-forming spray. The selected literature included research on polymers as film-forming matrices and the application of these sprays for medical purposes or for potential medical use. This article discusses the types and concentrations of polymers and excipients, sprayer types, evaluations, and critical parameters in determining the sprayability and film characteristics. The review concludes that both natural and synthetic polymers that have in situ film or viscoelastic properties can be used to optimise topical drug delivery.

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Section: Definition and Mechanism Of A Film-forming Spraymentioning

confidence: 99%

“…30,32,33 The average spray angle of MDS is 83.51°. 20 The average leakage rate of an MDS container is 0.01-0.02 %. 30…”

Section: Metered Dose Spraymentioning

confidence: 99%

Section: Eudragitmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<p>Film-Forming Sprays for Topical Drug Delivery</p>

Umar¹,

Butarbutar²,

Sriwidodo³

et al. 2020

DDDT

View full text Add to dashboard Cite

show abstract

“…The importance of spray breakup associated phenomena for various applications is well recognized and has been extensively investigated experimentally and numerically by engineers, environmentalists, automotive industrialists, pharmaceutics, and agriculturists [21,[37][38][39][40][41]. A rigorous representation of spray breakup is very complicated procedure as it would involve accurate estimation of nozzle flow, initial formation of ligaments, instabilities, cavitation, and droplets associated physics and their subsequent breakup, heating, evaporation, the entrainment of air and the effects of turbulence [21,40].…”

Section: Atomizationmentioning

confidence: 99%

Atomization of Bio-Fossil Fuel Blends

Qubeissi¹,

Al-Esawi²,

Kolodnytska³

2018

Advances in Biofuels and Bioenergy

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The importance of modeling multi-component fuel atomization, heating and evaporation has been recognized in many studies. The predictions of these models are crucial to the design and performance of combustion engines. Accurate modeling is essential to the understanding of these processes and ultimately to improving engine sustainability and reducing emission. The interest in bio-fossil fuel blends has been mainly stimulated by depletion of fossil fuels and the need to reduce carbon dioxide emissions that contribute towards climate change. This work presents a review of recent investigations into the heating and evaporation of multi-component blended fuel droplets in real internal combustion engine (ICE) conditions. The models consider the contribution of all groups of hydrocarbons in fossil (gasoline, diesel) fuels, methyl esters in 22 biodiesel fuels, and ethanol fuel. Diffusion of these fuel species, temperature gradient, and recirculation within droplets are accounted for. One important finding is that some fuel blends, for example B5 (5% biodiesel fuel and 95% diesel fuel) and E5 (5% ethanol fuel and 95% gasoline fuel), can give almost identical droplet lifetimes to the ones predicted for pure diesel and gasoline fuels; i.e. such mixtures can be directly used in conventional engines without modification.

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Bupivacaine‐eluting soy protein structures for controlled release and localized pain relief: An in vitro and in vivo study

Goder

Giladi

Furer

et al. 2021

J Biomedical Materials Res

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Burn pain is known to be excruciating, and while burn care has greatly advanced, treatment for burn‐related pain is lacking. Current pain relief methods include systemic administration of analgesics, which does not provide high drug concentration at the wound site. In the present study, soy protein was used as the base material for bupivacaine‐loaded hybrid wound dressings. The effect of the formulation on the drug release profile was studied using high performance liquid chromatography, and the cytotoxicity was tested on human fibroblasts. A second‐degree burn model in rats was used to quantify the efficacy of the wound dressings in vivo, using the Rat Grimace Scale. All tested films exhibited high biocompatibility, and the drug release profiles showed rapid release during the initial 5 hr and a continuous slower release for another 24 hr. Significant pain relief was achieved in the animal trials, proving a decrease of 51–68% in pain levels during days 1–3 post‐burn. Hence, the results indicate a safe and controlled bupivacaine release for a period of more than 24 hr, effectively treating pain caused by second‐degree burns. The understanding of the formulation‐properties effects, together with our in vivo study, enables to advance this field toward tailorable systems with high therapeutic potential.

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Fabrication of topical metered dose film forming sprays for pain management

Cited by 35 publications

References 26 publications

<p>Film-Forming Sprays for Topical Drug Delivery</p>

<p>Film-Forming Sprays for Topical Drug Delivery</p>

Atomization of Bio-Fossil Fuel Blends

Bupivacaine‐eluting soy protein structures for controlled release and localized pain relief: An in vitro and in vivo study

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