<p>Film-Forming Sprays for Topical Drug Delivery</p>

Abstract

Film-forming sprays offer many advantages compared to conventional topical preparations because they can provide uniform drug distribution and dose, increased bioavailability, lower incidence of irritation, continuous drug release, and accelerated wound healing through moisture control. Film-forming sprays consist of polymers and excipients that improve the characteristics of preparations and enhance the stability of active substances. Each type of polymer and excipient will produce films with different features. Therefore, the various types of polymers and excipients and their evaluation standards need to be examined for the development of a more optimal form of film-forming spray. The selected literature included research on polymers as film-forming matrices and the application of these sprays for medical purposes or for potential medical use. This article discusses the types and concentrations of polymers and excipients, sprayer types, evaluations, and critical parameters in determining the sprayability and film characteristics. The review concludes that both natural and synthetic polymers that have in situ film or viscoelastic properties can be used to optimise topical drug delivery.

Effectiveness of the Natural-Based Products and Mucoadhesive for Recurrent Aphthous Stomatitis Therapy: A Systematic Review

“…The film formula has the advantage of being easily soluble, more stable, and durable, but it is fragile and hygroscopic; thus, it must be stored in a dry place and requiring special packaging for product stability [37]. The spray formula has the advantage of having a large coverage area and the dosage was adjustable based on the needs, while the disadvantage was lack of stability [38]. The mucoadhesive in this review consist of: HPMC, HPEC, Benzocaine, tragacanth gum, Carbomer 934 and Sodium CMC, and also chitosan.…”

Film-Forming Spray of Water-Soluble Chitosan Containing Liposome-Coated Human Epidermal Growth Factor for Wound Healing

“…Water-sensitive paper was used to obtain a clear pattern down to the size distribution of the spray droplets. The nozzle used was an ordinal spray nozzle [ 22 ]. The diameter of the fixed pattern was then measured to determine the spray angle.…”

“…However, the use of acids to dilute chitosan can produce distinctive aromas that are uncomfortable and can irritate wound mucosal tissue [ 21 ]. The application of hydrogel preparations also allows cross-infection, nonuniform dosage, and uneven drug distribution [ 22 ]. Therefore, we developed a film-forming spray using water-soluble chitosan containing hEGF-liposomes as a potential preparation for wound healing.…”

Non-Pressurized Topical Spray Pharmaceutical-Methodology of Formulation Development and Quality Control Management

“…If any other mixtures or proprietary preparations are used as formulation components, they must be thoroughly documented, including their identities and entire composition statements. 4…”