muscle cells, neomuscle fibers, neoglycosaminoglycans, and neocapillaries in the implanted tissue. 11 Similarly, Gálvez-Montón et al 12 reported that engraftment of an acellular human pericardial scaffold over porcine infarcted myocardium prompted scaffold neoinnervation and neovascularization. Decellularized ECM may also be used as cell supportive material, or even to incorporate bioactive factors for prolonged retention, facilitating their local delivery and action. Perea-Gil et al 8 repopulated decellularized ECM of both myocardial and pericardial origin with adipose tissue-derived mesenchymal cells (MSCs). The decellularized pericardial scaffold demonstrated better cell infiltration and retention and larger pore size. Both myocardial and pericardial scaffolds were further evaluated in a porcine model of myocardial infarction, showing integration with the underlying myocardium, signs of neovascularization and nerve sprouting, and ventricular function recovery 40 days after scaffold implantation.In the referred report, Liu et al evaluated the capability of porous bovine pericardial scaffolds to load and release basic fibroblast growth factor (bFGF), a potent mitogen that regulates the migration, differentiation, and growth of different cell types and plays an important role in tissue repair and regeneration. They showed that bFGF is easily absorbed, penetrates the porous scaffolds and was effectively released in vitro in a concentration-dependent manner. 7 Furthermore, when these scaffolds were subcutaneously implanted in the rat model, they promoted MSC recruitment and inhibited myofibroblast differentiation, indicating that the released bFGF preserved its bioactivity in vivo. 7