Fabrication of poly(ethylene oxide) hydrogels for wound dressing application using E-beam

Haryanto,; Kim, SeongCheol; Kim, Jeong Hwan; Kim, Jong Oh; Ku, Sae‐Kwang; Cho, Hyun-Kug; Han, Do Hung; Huh, PilHo

doi:10.1007/s13233-014-2023-z

Cited by 62 publications

(19 citation statements)

References 25 publications

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“…As expected, the Young’s moduli of hydrogel films increased linearly with increasing PETRA concentration. These moduli values are comparable to those of PEO/poly(ethylene glycol) diacrylate (PEGDA) hydrogels formulated for wound dressing application via electron beam [ 23 ]. Furthermore, the moduli of films containing 5% w / w and 10% w / w PETRA are within the literature Young’s modulus of the human skin (4.6–20 MPa) obtained from extension tests [ 24 ].…”

Section: Resultsmentioning

confidence: 67%

“…It can be seen from Figure 4 a that the tensile strength of PEO hydrogel samples increased linearly with increasing PETRA concentration due to the increased crosslinking density. Films containing 10% w / w PETRA concentration possessed highest tensile strength (1.41 ± 0.12 MPa), which is approximately 32 times higher than that of pure PEO films fabricated via electron beam (0.044 MPa) [ 23 ]. Statistical analysis showed that films prepared with 5% w / w and 10% w / w PETRA concentration possessed significantly higher tensile strength, as their obtained tensile values were significantly different between all tested groups (see Figure 4 a).…”

Section: Resultsmentioning

confidence: 99%

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Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

2015

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Novel polyethylene oxide (PEO) hydrogel films were synthesized via UV crosslinking with varying concentrations of pentaerythritol tetra-acrylate (PETRA) as crosslinking agent. The aim was to study the effects of the crosslinking agent on the material properties of hydrogel films intended for dermatological applications. Fabricated film samples were characterized using swelling studies, scanning electron microscopy, tensile testing and rheometry. Films showed rapid swelling and high elasticity. The increase of PETRA concentration resulted in significant increase in the gel fraction and crosslinking density (ρc), while causing a significant decrease in the equilibrium water content (EWC), average molecular weight between crosslinks (trueM¯normalc), and mesh size (ζ) of films. From the scanning electron microscopy, cross-linked PEO hydrogel network appeared as cross-linked mesh-like structure with interconnected micropores. Rheological studies showed PEO films required a minimum of 2.5% w/w PETRA to form stable viscoelastic solid gels. Preliminary studies concluded that a minimum of 2.5% w/w PETRA is required to yield films with desirable properties for skin application.

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Section: Resultsmentioning

confidence: 67%

Section: Resultsmentioning

confidence: 99%

Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

2015

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“…5,24 Nevertheless, hydrogels can be used as bandage material and drug delivery system simultaneously. 25,26 Hydrogels are three-dimensional polymeric networks synthesised of highly hydrophilic monomers. 27 There is a great variety of monomers used in hydrogel synthesis, such as polyamides, 28 poly (ethylene oxide), 29 polyacryl acid derivates, [30][31][32] gelatin 33 and many more.…”

Section: Introductionmentioning

confidence: 99%

Uptake and release of photosensitizers in a hydrogel for applications in photodynamic therapy: the impact of structural parameters on intrapolymer transport dynamics

et al. 2018

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“…Due to their significant water content, PEO‐based hydrogels possess a degree of flexibility similar to a tissue. Therefore, they have good biocompatibility with low toxicity and have been exploited in many fields, including tissue engineering, drug delivery, wound dressing, and an antiadhesion barriers . PEO and chemically similar poly(ethylene glycol) (PEG) are hydrophilic polymers that can be photocrosslinked by modifying each end of the polymer with either acrylates or methacrylates .…”

Section: Introductionmentioning

confidence: 99%

“…Electron beam (e‐beam) irradiation is a relatively simple method for the modification of polymeric materials through cross‐linking, grafting, and degradation reactions . Moreover, the radiation dose can be easily controlled and the experimental condition is simple . In addition, the product is free from undesirable chemical impurities such as residues from initiators for initiation and manipulation of the cross‐linking reaction in chemical cross‐linking methods .…”

Section: Introductionmentioning

confidence: 99%

Hyperbranched poly(glycidol)/poly(ethylene oxide) crosslinked hydrogel for tissue engineering scaffold using e‐beams

Haryanto

Singh

Huh

et al. 2015

J Biomedical Materials Res

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A microporous hydrogel scaffold was developed from hyperbranched poly(glycidol) (HPG) and poly(ethylene oxide) (PEO) using electron beam (e-beam) induced cross-linking for tissue engineering applications. In this study, HPG was synthesized from glycidol using trimethylol propane as a core initiator and cross-linked hydrogels were made using 0, 10, 20, and 30% HPG with respect to PEO. The effects of %-HPG on the swelling ratio, cross-linking density, mechanical properties, morphology, degradation, and cytotoxicity of the hydrogel scaffolds were then investigated. Increasing the HPG content increased the pore size of the hydrogel scaffold, as well as the porosity, elongation at break, degree of degradation and swelling ratio. In contrast, the presence of HPG decreased the cross-linking density of the hydrogel. There was no significant difference in compressive modulus and tensile strength of all compositions. The pore size of hydrogel scaffolds could be easily tailored by controlling the content of HPG in the polymer blend. Evaluation of the cytotoxicity demonstrated that HPG/PEO hydrogel scaffold has potential for use as a matrix for cellular attachment and proliferation. These results indicate that cross-linked HPG/PEO hydrogel can function as a potential material for tissue engineering scaffolds. Moreover, a facile method to prepare hydrogel microporous scaffolds for tissue engineering by e-beam irradiation was developed.

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Fabrication of poly(ethylene oxide) hydrogels for wound dressing application using E-beam

Cited by 62 publications

References 25 publications

Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

Uptake and release of photosensitizers in a hydrogel for applications in photodynamic therapy: the impact of structural parameters on intrapolymer transport dynamics

Hyperbranched poly(glycidol)/poly(ethylene oxide) crosslinked hydrogel for tissue engineering scaffold using e‐beams

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