Fabrication of poly(acrylic acid) grafted-chitosan/polyurethane/magnetic MIL-53 metal organic framework composite core-shell nanofibers for co-delivery of temozolomide and paclitaxel against glioblastoma cancer cells

Bazzazzadeh, Amin; Dizaji, Babak Faraji; Kianinejad, Nazanin; Nouri, Arezo; Irani, Mohammad

doi:10.1016/j.ijpharm.2020.119674

Cited by 76 publications

(29 citation statements)

References 54 publications

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“…These porous crystalline materials are used in various fields because of having an excellent surface area, stability, porosity, and biocompatibility [ 119 ]. MOFs are frequently utilized as nanocarriers because of having good loading efficacy and sustained drug release properties [ 120 ].…”

Section: Bio-conjugation With Other Materialsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

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Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained lots of interest in recent years. PAA nano-derivatives can be obtained by chemical modification of carboxyl groups with superior chemical properties in comparison to unmodified PAA. For example, nano-particles produced from PAA derivatives can be used to deliver drugs due to their stability and biocompatibility. PAA and its nanoconjugates could also be regarded as stimuli-responsive platforms that make them ideal for drug delivery and antimicrobial applications. These properties make PAA a good candidate for conventional and novel drug carrier systems. Here, we started with synthesis approaches, structure characteristics, and other architectures of PAA nanoplatforms. Then, different conjugations of PAA/nanostructures and their potential in various fields of nanomedicine such as antimicrobial, anticancer, imaging, biosensor, and tissue engineering were discussed. Finally, biocompatibility and challenges of PAA nanoplatforms were highlighted. This review will provide fundamental knowledge and current information connected to the PAA nanoplatforms and their applications in biological fields for a broad audience of researchers, engineers, and newcomers. In this light, PAA nanoplatforms could have great potential for the research and development of new nano vaccines and nano drugs in the future.

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Section: Bio-conjugation With Other Materialsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

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“…This type of 'multi-stable phase' works as a response to the environment and is only activated through external stimuli, such as the entry of guest molecules, which changes the pressure, magnetic field, or light in the vicinity of the pore [58][59][60][61]. Regarding this property, the MOF that best exemplifies the flexor capacity of these materials is the MIL-53, which has a structure similar to a wine rack [62][63][64].…”

Section: Properties Of Metal-organic Frameworkmentioning

confidence: 99%

A Comprehensive Review on the Use of Metal–Organic Frameworks (MOFs) Coupled with Enzymes as Biosensors

et al. 2022

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Several studies have shown the development of electrochemical biosensors based on enzymes immobilized in metal–organic frameworks (MOFs). Although enzymes have unique properties, such as efficiency, selectivity, and environmental sustainability, when immobilized, these properties are improved, presenting significant potential for several biotechnological applications. Using MOFs as matrices for enzyme immobilization has been considered a promising strategy due to their many advantages compared to other supporting materials, such as larger surface areas, higher porosity rates, and better stability. Biosensors are analytical tools that use a bioactive element and a transducer for the detection/quantification of biochemical substances in the most varied applications and areas, in particular, food, agriculture, pharmaceutical, and medical. This review will present novel insights on the construction of biosensors with materials based on MOFs. Herein, we have been highlighted the use of MOF for biosensing for biomedical, food safety, and environmental monitoring areas. Additionally, different methods by which immobilizations are performed in MOFs and their main advantages and disadvantages are presented.

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“…There were constraints on defining the chromosome of the algorithm regarding production restrictions. Chromosomes include feeding ratio of sheath to core with a constraint of [1][2], CS percent in sheath with a constraint of [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23], nanoparticle percentage with a constraint of [1][2][3][4][5][6][7], and drug percentage with a constraint of [1][2][3][4][5].…”

Section: Practical Basismentioning

confidence: 99%

“…(1) Wherein RTRmax was maximum release amount in maximum release time, BR was burst release which was the release amount in the first 30min, TRmax was the maximum release time, and Le was drug loading efficiency. A MATLAB code was used for genetic algorithm whose parameters are population size (20), the number of generations (100), creation function (Roulette wheel), the number of elites (1), cross over fraction (0.8), migration fraction (0.2), mutation fraction (0.2), migration direction A c c e p t e d M a n u s c r i p t (forward), fitness limit (0), function tolerance (10 -6 ), and maximum stall generation (5). Stopping conditions consisted of either reaching to 100 generations, or achieving zero for fitness value, or having the best fitness value difference less than the function tolerance for 5 consecutive generations.…”

Section: Practical Basismentioning

confidence: 99%

“…The cell cytotoxicity indicated that 31.3 and 49.6% of apoptosis cell was occurred for U-87 MG glioblastoma cells treated with CS-g-PAA-TMZ-PTX/PU/magnetic MIL-53 in the absence and presence of AMF, respectively. 20 The aim of this study was to encapsulate 5FU and Fe3O4 nanoparticles in core-shell PCL/CS nanofibers as a multi-mode anticancer system which could provide chemotherapy and hyperthermia simultaneously. Despite 5FU has a low half-life of 8 to 20 min 21 , core-shell structure of the nanofiber contributes to a more sustainable release system of the drug in comparison with blend structure, which was studied in previous work 1 .…”

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confidence: 99%

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5FU-loaded PCL/Chitosan/Fe₃O₄ Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System

et al. 2021

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Purpose: 5FU and Fe3O4 nanoparticles were encapsulated in core-shell Polycaprolactone/Chitosan nanofibers as a multi-mode anticancer system to study drug release sustainability. The structure of the core-shell drug delivery system was also optimized according to drug release behavior by artificial intelligence. Methods: The core-shell nanofibers were electrospun by a coaxial syringe. ANN was used for function approximation to estimate release parameters. A genetic algorithm was then used for optimizing the structure. Chemical assay of the optimized sample was performed by FTIR, XRD, and EDX. VSM test was conducted to measure the real amount of loaded magnetic nanoparticles. HepG2 cell cytotoxicity was studied and the results for the optimized samples with and without Fe3O4 after 72hrs were reported. Results: Feeding ratio of sheath to core and the amount of CS, Fe3O4, and 5FU had a statistical effect on nanofibers diameters, which were 300-450nm. The drug loading efficiency of these nanofibers was 65-86%. ANN estimated the release parameters with an error of 10%. The temperature increased about 5.6°C in the AMF of 216kA.m-1~300kHz and 4.8°C in the AMF of 154kA.m-1~400kHz after 20min. HepG2 cell cytotoxicity for the optimized samples with and without Fe3O4 after 72hrs were 39.7% and 38.8%, respectively. Conclusion: Since this core-shell drug release system was more sustainable compared to the blend structure despite the low half-life of 5FU, it is suggested to utilize it as post-surgical implants for various cancer treatments such as liver or colorectal cancer in the future. This system is capable of providing chemotherapy and hyperthermia simultaneously.

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Fabrication of poly(acrylic acid) grafted-chitosan/polyurethane/magnetic MIL-53 metal organic framework composite core-shell nanofibers for co-delivery of temozolomide and paclitaxel against glioblastoma cancer cells

Cited by 76 publications

References 54 publications

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

A Comprehensive Review on the Use of Metal–Organic Frameworks (MOFs) Coupled with Enzymes as Biosensors

5FU-loaded PCL/Chitosan/Fe₃O₄ Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System

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Fabrication of poly(acrylic acid) grafted-chitosan/polyurethane/magnetic MIL-53 metal organic framework composite core-shell nanofibers for co-delivery of temozolomide and paclitaxel against glioblastoma cancer cells

Cited by 76 publications

References 54 publications

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

A Comprehensive Review on the Use of Metal–Organic Frameworks (MOFs) Coupled with Enzymes as Biosensors

5FU-loaded PCL/Chitosan/Fe3O4 Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System

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5FU-loaded PCL/Chitosan/Fe₃O₄ Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System