Fabrication of patterned polymer-antibiotic composite fibers via electrohydrodynamic (EHD) printing

Wang, Jun-Chuan; Chang, Ming‐Wei; Ahmad, Zeeshan; Li, Jingsong

doi:10.1016/j.jddst.2016.06.009

Cited by 44 publications

(26 citation statements)

References 66 publications

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“…The presence of PVP polymer was confirmed by absorbance at 1018 and 1290 cm -1 , which are assigned to C-N stretching. Characteristic absorption bands at 2358 and 2954 cm -1 belong to stretching vibrations of C-H. Another characteristic peak attributed to stretching vibrations is found at 1496 cm -1 and is attributed to C=O [12]. PCL polymer produces a strong carbonyl (C=O) peak at 1729 cm -1 and other absorptions between 2868 and 2949 cm -1 arising from methylene (CH2) groups [15], Similar bands are observed in spectra for constructs P1-P5 shown in Fig.…”

Section: Fourier Transform Infra-red Spectroscopysupporting

confidence: 73%

“…4(b). Characteristic absorption peaks for TE-HCL are observed at 1246 cm -1 (C-N), 1288 cm -1 (C-H stretching vibration) and 1460 cm -1 (O-H stretching vibration) for all spectra of constructs hosting the antibiotic [12], as shown in Fig. 4(b).…”

Section: Fourier Transform Infra-red Spectroscopymentioning

confidence: 92%

“…Polyvinylpyrrolidone (PVP) is a synthetic, biocompatible and non-toxic polymer which has been widely used as a pharmaceutical excipient (for dosage form development) [11,12]. Polycaprolactone (PCL) is a hydrophobic polymer with desirable physicochemical properties, which has been used in diffusion-controlled delivery systems [13].…”

Section: Introductionmentioning

confidence: 99%

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Development of random and ordered composite fiber hybrid technologies for controlled release functions

Wang

Ahmad

Huang

et al. 2018

Chemical Engineering Journal

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Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCL) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate antibacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.

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Section: Fourier Transform Infra-red Spectroscopysupporting

confidence: 73%

Section: Fourier Transform Infra-red Spectroscopymentioning

confidence: 92%

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Development of random and ordered composite fiber hybrid technologies for controlled release functions

Wang

Ahmad

Huang

et al. 2018

Chemical Engineering Journal

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“…The FTIR spectrum corresponding to pure PVP shows an absorbance at 1292 and 1018cm -1 , which is assigned to C-N stretching (Fig.3a) [11]. The spectrum for silicone oil displays absorptions in the regions: 1260 and 1080cm -1 due to Si-C and Si-O bands [12].…”

Section: Resultsmentioning

confidence: 97%

“…PVP is a synthetic, biocompatible and non-toxic polymer which has been widely applied as a pharmaceutical excipient [11]. KCZ is an active drug agent and has been utilized to treat superficial and internal fungal indications [12].…”

Section: Introductionmentioning

confidence: 99%

Non-concentric multi-compartment fibers fabricated using a modified nozzle in single-step electrospinning

Wang

Chang

et al. 2017

Materials Letters

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Multi-compartment fibers with well-defined regions and functional media hosting potential provide coencapsulation opportunities for a variety of bio-molecules, drugs and even nutrients. In this research, fibers possessing multiple compartments were prepared using the single-step electrospinning method and a modified nonconcentric multi-needle. Polyvinyl pyrrolidone (PVP) was used as the fiber shell material, while ketoconazole (KCZ, model drug) and Sudan Red (model probe) were encapsulated as two separate segments running along the fiber length. Multi-compartment fiber morphology and structure were examined using optical and electron microscopy.The effect of flow rate on fiber morphology was also investigated and the release of encapsulated KCZ and Sudan Red was examined using UV spectroscopy. The results present an efficient and promising method to engineer multicompartment fibers in a single step for several biomedical applications in lieu.

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Engineering On‐Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro‐Scale Printing

et al. 2019

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Herein, electrohydrodynamic (EHD) printing is utilized to produce well-ordered, dual-drug loaded-magnetic core-shell matrices with high resolution. Coaxial EHD printing is used to load anesthetic lidocaine hydrochloride (LH) and antibiotic tetracycline hydrochloride (TH) in polycaprolactone (PCL) shell formulation and poly (ethylene oxide) (PEO) core formulation, respectively. It is found that when the concentration of PEO is 5% w/w, the fibers exhibit optimum morphology, which is applied in the fabrication of two drug-loaded core-shell fibers. In addition, adding iron oxide (Fe 3 O 4 ) nanoparticles (NPs) and varying the concentration of TH within the PCL shell layer influence mechanical properties, release behaviors, and cell behaviors of coaxial EHD printing matrices. The addition of Fe 3 O 4 NPs and increasing TH amount in the fibers enhance the mechanical properties of the matrices. Results show rapid release of LH located in the PEO core fibers, while TH loaded in the shell PCL fibers is released sustainably from the coaxial printing matrices. In addition, the sustainable release period for PCL shell layer can be adjusted using Fe 3 O 4 NPs under auxiliary magnetic field. The coaxial drug-loaded matrices also have good bioactivity, indicating the potential of the printed fibers in wound dressings.

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Fabrication of patterned polymer-antibiotic composite fibers via electrohydrodynamic (EHD) printing

Cited by 44 publications

References 66 publications

Development of random and ordered composite fiber hybrid technologies for controlled release functions

Development of random and ordered composite fiber hybrid technologies for controlled release functions

Non-concentric multi-compartment fibers fabricated using a modified nozzle in single-step electrospinning

Engineering On‐Demand Magnetic Core–Shell Composite Wound Dressing Matrices via Electrohydrodynamic Micro‐Scale Printing

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