Non-concentric multi-compartment fibers fabricated using a modified nozzle in single-step electrospinning

Wang, Baolin; Wang, Meidi; Chang, Ming Wei; Ahmad, Zesshan; Huang, Jie; Li, Jing Song

doi:10.1016/j.matlet.2017.05.035

Cited by 9 publications

(5 citation statements)

References 16 publications

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“…Core-shell and Janus structures have been most widely researched in multifluid electrospinning. However, other multifluid electrospinning can also be used to develop more complex, for example, multichannel nanofibers were prepared by two to five working fluids packaged through sheath solution [82,83]; high-quality Janus fiber was fabricated by surrounding solvent by using a complex structure spinneret shown as Figure 4A(b and d) [55].…”

Section: Other Multifluid Electrospinning Processesmentioning

confidence: 99%

The Development and Bio-applications of Multifluid Electrospinning

Wang¹,

Yu²,

Li³

et al. 2020

MAHIG

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Electrospinning is a potent "top-down" nanofabrication method and has been explored by many researchers in recent decades because it is an efficient, versatile, simple, and low-cost route to prepare nanofibers. Nanofiber membranes generated by electrospinning have been used in various fields including tissue engineering, wound dressing, biosensing, theranostics, and functional textiles. Here we summarize the development of multifluid electrospinning processes, including coaxial, Janus and triaxial electrospinning, and the applications of these techniques. Complex nanostructures prepared by multifluid electrospinning are considered. The key parameters that affect the electrospinning process are introduced, and a discussion of both equipment and solution parameters is presented.

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Section: Other Multifluid Electrospinning Processesmentioning

confidence: 99%

The Development and Bio-applications of Multifluid Electrospinning

Wang¹,

Yu²,

Li³

et al. 2020

MAHIG

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“…The hydrophilicity of the CA patches was also very important for the corneal abrasions treatment and drug release behaviors. [40] It was investigated by contact angle and interfacial tension analysis (DAS30, KRUSS, Germany) in this study. The sitting drop method was used to study the contact angle of a drop of pure water (5 μL) on the surfaces of CA patches loading different concentrations of CAM at the contact point.…”

Section: Methodsmentioning

confidence: 99%

3D Electrohydrodynamic Printing of Contact Lens‐Like Chloramphenicol‐Loaded Patches for Corneal Abrasions Treatment

Sun

Wang

et al. 2022

Adv Eng Mater

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Corneal abrasion is a common traumatic emergency, which can cause eyelid photophobia, tearing, and obvious foreign body sensation and pain. Herein, the 3D contact lens‐like chloramphenicol‐loaded patches composed of well‐organized micrometer fibers are prepared via electrohydrodynamic (EHD) printing to treat corneal abrasions. The main material of these patches is cellulose acetate (CA), and chloramphenicol (CAM) is loaded in the patches. EHD printing can realize micrometer fibers stacked layer by layer to form a customizable shape suitable for eye wear. Herein, the surface morphology, chemical as well as physical properties, transparency, drug release behaviors, and biocompatibility of the patches loading various concentrations of CAM are studied. It is found that the CAM‐loaded patches have 3D hemispherical shape similar to contact lens and smooth surface morphology. Moreover, patches loaded with different concentrations of CAM all maintain good water absorption, hydrophilicity, light transmittance, and biocompatibility. The drug release curves of CAM‐loaded patches show that the contact lens‐like patches have high loading efficiency and can achieve sustained release of CAM, indicating clinical potential in the treatment of corneal abrasions.

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“…Thus, wettability is influenced primarily by surface characteristics which in turn impacts bio-interface behaviour [32,33]. In addition, wettability has also been shown to modulate hydrophobicity, which is an important parameter in drug release from a delivery system [34]. Therefore, the constructs produced in this study incorporate both subsequently reduced to ~0° after 100s.…”

Section: Construct Hydrophilicitymentioning

confidence: 97%

Development of random and ordered composite fiber hybrid technologies for controlled release functions

Wang

Ahmad

Huang

et al. 2018

Chemical Engineering Journal

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Fibrous technologies (such as membranes, films, patches and filters) and their enabling engineering platforms have gained considerable interest over the last decade. In this study, novel fibrous constructs from a unique engineering platform were developed based on hybrid electrohydrodynamic (EHD) technology; incorporating functional and bioactive materials within random and aligned fibrous formulation geometries. Complex constructs were engineered using 3D printing (polycaprolactone, PCL, for sustained delivery) and electrospinning (polyvinylpyrolidone, PVP, for rapid release) in an intercalating material layer-by-layer format using a side-by-side technological approach. Here, structure generation proceeded with deposition of ordered PCL fibers enabling well-defined void size and overall dimension, after which randomly spun PVP fibers formed a construct overcoat (as a membrane). Differences between polymer dissolution rate, hydrophilicity, mechanical properties and functional material hosting (and linked external auxiliary magnetic field trigger) provided opportunities to modulate antibiotic drug (tetracycline hydrochloride, TE-HCL) release. In vitro cell studies using human umbilical vein blood vessel cell line demonstrated device biocompatibility and Escherichia Coli (E. coli) was selected to demonstrate antibacterial function. Overall, a new hybrid engineering platform to prepare customizable and exciting multi-faceted drug release constructs is elucidated.

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Non-concentric multi-compartment fibers fabricated using a modified nozzle in single-step electrospinning

Cited by 9 publications

References 16 publications

The Development and Bio-applications of Multifluid Electrospinning

The Development and Bio-applications of Multifluid Electrospinning

3D Electrohydrodynamic Printing of Contact Lens‐Like Chloramphenicol‐Loaded Patches for Corneal Abrasions Treatment

Development of random and ordered composite fiber hybrid technologies for controlled release functions

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