Fabrication of nanopatterned PLGA films of curcumin and TPGS for skin cancer

Malathi, S.; Pavithra, P; Sridevi, S.; Verma, Rama Shanker

doi:10.1016/j.ijpharm.2020.119100

Cited by 16 publications

(8 citation statements)

References 38 publications

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“…The cytotoxic activity of curcumin-loaded NPFs were then compared to unpatterned films using a human skin cancer cell line (A431). D-α-Tocopheryl polyethylene glycol 1000 succinate (TGPS) which is an emulsifier, a solubilizing agent, a permeation enhancer, and a stabilizer in drug formulations was used along with curcumin in the nanopattern films to overcome the physicochemical limitations associated with curcumin use [77]. The investigation showed that curcumin-loaded TGPS stabilized PLGA NPFs exhibited good in vitro cytotoxic activity against human skin cancer cells when compared to unpatterned films.…”

Section: Nanopatterned Films (Npfs)mentioning

confidence: 99%

Nano-based formulations of curcumin: elucidating the potential benefits and future prospects in skin cancer

Ratan,

Arian,

Rajendran

et al. 2023

Biomed. Mater.

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Skin cancer refers to any malignant lesions that occur in the skin and are observed predominantly in populations of European descent. Conventional treatment modalities such as excision biopsy, chemotherapy, radiotherapy, immunotherapy, electrodesiccation, and photodynamic therapy induce several unintended side effects which affect a patient’s quality of life (QOL) and physical well-being. Therefore, spice-derived nutraceuticals like curcumin, which are well tolerated, less expensive, and relatively safe, have been considered a promising agent for skin cancer treatment. Curcumin, a chemical constituent extracted from the Indian spice, turmeric, and its analogues has been used in various mammalian cancers including skin cancer. Curcumin has anti-neoplastic activity by triggering the process of apoptosis and preventing the multiplication and infiltration of the cancer cells by inhibiting some signalling pathways and thus subsequently preventing the process of carcinogenesis. Curcumin is also a photosensitizer and has been used in PDT. The major limitations associated with curcumin are poor bioavailability, instability, limited permeation into the skin, and lack of solubility in water. This will constrain the use of curcumin in clinical settings. Hence, developing a proper formulation that can ideally release curcumin to its targeted site is important. So, several nanoformulations based on curcumin have been established such as nanogels, nanoemulsions, nanofibers, nanopatterned films, nanoliposomes and nanoniosomes, nanodisks, and cyclodextrins. The present review mainly focuses on curcumin and its analogues as therapeutic agents for treating different types of skin cancers. The significance of using various nanoformulations as well non-nanoformulations loaded with curcumin as an effective treatment modality for skin cancer is also emphasized.

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Section: Nanopatterned Films (Npfs)mentioning

confidence: 99%

Nano-based formulations of curcumin: elucidating the potential benefits and future prospects in skin cancer

Ratan,

Arian,

Rajendran

et al. 2023

Biomed. Mater.

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“…PLGA-Cur combinations have also been studied for skin cancer cells. Malathi et al 65 fabricated nano-patterned PLGA films via Fig. 3 PLGA is hydrolyzed into lactic acid and glycolic acid.…”

Section: Drug Encapsulation Into Plga Conjugatesmentioning

confidence: 99%

“…PLGA–Cur combinations have also been studied for skin cancer cells. Malathi et al 65 fabricated nano-patterned PLGA films via a polydimethylsiloxane cast molding technique and investigated its therapeutic efficacy in combination with Cur and tocopherol poly(ethylene glycol) for skin cancer treatment. As observed by Vakilinezhad and co-workers, the nano-patterned films displayed significantly higher cytotoxicity towards skin cancer cells when compared to the unpattern films.…”

Section: Plgamentioning

confidence: 99%

Progress in the drug encapsulation of poly(lactic-co-glycolic acid) and folate-decorated poly(ethylene glycol)–poly(lactic-co-glycolic acid) conjugates for selective cancer treatment

et al. 2022

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“…The output of this study shows that the use of these nanocapsules increased the anticolorectal cancer characteristics through inhibiting Wnt/β‐catenin, frizzled (Frz), cyclin D1, transcription factor 4 (Tcf4), c‐Myc, lymphoid enhancer‐binding factor 1 (Lef1) signaling pathways, increasing adenomatous polyposis coli, and glycogen synthase kinase (GSK3β) expression. In another study, Malathi, Pavithra, Sridevi, and Verma (2020) revealed the therapeutic potential of poly (lactic‐co‐glycolic acid) nanofilms containing Cur and tocopherol poly (ethylene glycol) 1,000 succinate to treat skin papilloma cancer in Swiss albino mice by inhibiting cutaneous squamous cell carcinoma progression. To improve solubility, stability, and biological availability of Cur, Mardani et al (2020) evaluated the anticancer efficacy of Cur nanomicellar in a mouse melanoma lung metastasis model.…”

Section: Cur Nanoformulations As Promising Strategies For the Treatme...mentioning

confidence: 99%

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Khezri

Saeedi

Mohammadamini

et al. 2021

Phytotherapy Research

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Today, due to the prevalence of various diseases such as the novel coronavirus (SARS-CoV-2), diabetes, central nervous system diseases, cancer, cardiovascular disorders, and so on, extensive studies have been conducted on therapeutic properties of natural and synthetic agents. A literature review on herbal medicine and commercial products in the global market showed that curcumin (Cur) has many therapeutic benefits compared to other natural ingredients. Despite the unique properties of Cur, its use in clinical trials is very limited. The poor biopharmaceutical properties of Cur such as short half-life in plasma, low bioavailability, poor absorption, rapid metabolism, very low solubility (at acidic and physiological pH), and the chemical instability in body fluids are major concerns associated with the clinical applications of Cur.Recently, nanoformulations are emerging as approaches to develop and improve the therapeutic efficacy of various drugs. Many studies have shown that Cur nanoformulations have tremendous therapeutic potential against various diseases such as SARS-CoV-2, cancer, inflammatory, osteoporosis, and so on. These nanoformulations can inhibit many diseases through several cellular and molecular mechanisms. However, successful long-term clinical results are required to confirm their safety and clinical efficacy. The present review aims to update and explain the therapeutic potential of Cur nanoformulations.

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Fabrication of nanopatterned PLGA films of curcumin and TPGS for skin cancer

Cited by 16 publications

References 38 publications

Nano-based formulations of curcumin: elucidating the potential benefits and future prospects in skin cancer

Nano-based formulations of curcumin: elucidating the potential benefits and future prospects in skin cancer

Progress in the drug encapsulation of poly(lactic-co-glycolic acid) and folate-decorated poly(ethylene glycol)–poly(lactic-co-glycolic acid) conjugates for selective cancer treatment

A comprehensive review of the therapeutic potential of curcumin nanoformulations

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