Fabrication of macroporous soft hydrogels of Chitosan scaffolds by hydrothermal reaction and cytotoxicity to 3T3 L1 cells

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

“…[106] Copyright  2017, Elsevier], chemical structures of chitosan, and its carboxyalkyl derivatives Also, porous structure of the soft hydrogels can be tailored by varying genipin and chitosan concentrations [119] (Figure 3 A and B), as well as deacetylation degree (DDA) and molecular weight (MW) of the chitosan [120] (Figure 3C). More compact microstructures and improved mechanical properties of the chitosan hydrogel are reported by the use of succinic acid and urea, in addition to chemical crosslinking, in the presence of genipin [121]. Therefore, several studies have reported the utilization of the genipin-crosslinked chitosan for anti-bacterial material [122], as a carrier of drugs including 5-fluorouracil [123], cisplatin [124], and cytarabine [125], as well as for the treatment of diabetes [126] and diabetic wounds [127].…”

Natural polysaccharide-based aerogels and their applications in oil–water separations: a review

“…106 Due to its unique alkaline and cationic properties, chitosan can activate the sites of heavy metal ions as well as the sites of anionic organic pollutants, which has great application prospects in wastewater treatment. 107 In addition, there are a large number of chemically active groups in chitosan, which can be processed by physical (such as powdering, nanoparticles, and gel) 108 or chemical modification (crosslinking, grafting, etc. ) 109 to improve its thermal stability, mechanical properties, adsorption performance, and other characteristics.…”