Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew, Siriporn; Kaewkong, Worasak; Kriangkrai, Worawut

doi:10.3390/gels9040277

Cited by 32 publications

(18 citation statements)

References 223 publications

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“…Incorporating chitosan in hydrogels ensures improved biocompatibility and biodegradability, as well as elevated resistance to deformation and collapse [49,50]. Chitosan-based hydrogels have anti-bacterial abilities linked to the chitosan's positively charged amino groups that can interact with negatively charged components of the bacterial cell wall, increasing permeability and leading to cell damage [51].…”

Section: Advantages Of Chitosan-based Hydrogelsmentioning

confidence: 99%

“…These hydrogels are also valuable in the manufacture of adaptable surfaces or soft smart actuators [97,100]. In addition to biodegradability and biocompatibility, chitosan-based hydrogels are characterized by mechanical strength and elasticity, which may be adjusted by the cross-linking process and the addition of various photo-sensitive components [49]. The latter allows it to absorb contaminants, which is valuable in water purification [101].…”

Section: Photo-sensitive Hydrogelsmentioning

confidence: 99%

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Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Kruczkowska,

Gałęziewska,

Grabowska

et al. 2024

Gels

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Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative and distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization in drug encapsulation, transport, and controlled release, which is complemented by their biocompatibility, biodegradability, and non-immunogenic nature. Stimuli-responsive hydrogels, also known as smart hydrogels, have strictly regulated release patterns since they respond and adapt based on various external stimuli. Moreover, they can imitate the intrinsic tissues’ mechanical, biological, and physicochemical properties. These characteristics allow stimuli-responsive hydrogels to provide cutting-edge, effective, and safe treatment. Constant progress in the field necessitates an up-to-date summary of current trends and breakthroughs in the biomedical application of stimuli-responsive chitosan-based hydrogels, which was the aim of this review. General data about hydrogels sensitive to ions, pH, redox potential, light, electric field, temperature, and magnetic field are recapitulated. Additionally, formulations responsive to multiple stimuli are mentioned. Focusing on chitosan-based smart hydrogels, their multifaceted utilization was thoroughly described. The vast application spectrum encompasses neurological disorders, tumors, wound healing, and dermal infections. Available data on smart chitosan hydrogels strongly support the idea that current approaches and developing novel solutions are worth improving. The present paper constitutes a valuable resource for researchers and practitioners in the currently evolving field.

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Section: Advantages Of Chitosan-based Hydrogelsmentioning

confidence: 99%

Section: Photo-sensitive Hydrogelsmentioning

confidence: 99%

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Kruczkowska,

Gałęziewska,

Grabowska

et al. 2024

Gels

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“…By adding functional groups such as amino, sulfur, carboxyl, and alkyl, the adsorption capacity of hydrogels can be improved. The most important parameters influencing the grafting percentage are initiator type, initiator concentration, grafting time, monomer type, monomer concentration, and temperature [ 174 , 175 , 176 , 177 , 178 ]. Other factors that can influence the properties of grafted or functionalized CS are the molecular structure, length, and number of side chains [ 179 ].…”

Section: Categories Of Chitosan-based Hydrogels For Water Purificatio...mentioning

confidence: 99%

Chitosan Hydrogels for Water Purification Applications

Chelu,

Musuc,

Popa

et al. 2023

Gels

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Chitosan-based hydrogels have gained significant attention for their potential applications in water treatment and purification due to their remarkable properties such as bioavailability, biocompatibility, biodegradability, environmental friendliness, high pollutants adsorption capacity, and water adsorption capacity. This article comprehensively reviews recent advances in chitosan-based hydrogel materials for water purification applications. The synthesis methods, structural properties, and water purification performance of chitosan-based hydrogels are critically analyzed. The incorporation of various nanomaterials into chitosan-based hydrogels, such as nanoparticles, graphene, and metal-organic frameworks, has been explored to enhance their performance. The mechanisms of water purification, including adsorption, filtration, and antimicrobial activity, are also discussed in detail. The potential of chitosan-based hydrogels for the removal of pollutants, such as heavy metals, organic contaminants, and microorganisms, from water sources is highlighted. Moreover, the challenges and future perspectives of chitosan-based hydrogels in water treatment and water purification applications are also illustrated. Overall, this article provides valuable insights into the current state of the art regarding chitosan-based hydrogels for water purification applications and highlights their potential for addressing global water pollution challenges.

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“…Chitosan is a homopolysaccharide obtained from the deacetylation of chitin [ 1 , 2 ]. Chitosan is widely available, inexpensive, biocompatible, anti-immunogenic, antibacterial, antifungal, and functionalizable due to the presence of alcoholic and amino groups in its chain [ 1 , 3 , 4 ]. Chitosan is used in the biomedical field for drug and gene delivery, as a scaffold for the growth of various biological tissues both alone and in combination with other biomaterials, in biosensing, and in the treatment of diseases [ 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Multilayer Electrospun Scaffolds of Opposite-Charged Chitosans

Balducci,

Roso,

Zamuner

et al. 2024

IJMS

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Chitosan (CS) is a polysaccharide obtainable by the deacetylation of chitin, which is highly available in nature and is consequently low-cost. Chitosan is already used in the biomedical field (e.g., guides for nerve reconstruction) and has been proposed as a biomaterial for tissue regeneration in different body districts, including bone tissue. The interest in chitosan as a biomaterial stems from its ease of functionalization due to the presence of reactive groups, its antibacterial properties, its ease of processing to obtain porous matrices, and its inherent similarity to polysaccharides that constitute the human extracellular matrix, such as hyaluronic acid (HA). Here, chitosan was made to react with succinic anhydride to develop a negatively charged chitosan (SCS) that better mimics HA. FT-IR and NMR analyses confirmed the presence of the carboxylic groups in the modified polymer. Four different electrospun matrices were prepared: CS, SCS, a layer-by-layer matrix (LBL), and a matrix with both CS and SCS simultaneously electrospun (HYB). All the matrices containing SCS showed increased human osteoblast proliferation, mineralization, and gene expression, with the best results obtained with HYB compared to the control (CS). Moreover, the antibacterial potential of CS was preserved in all the SCS-containing matrices, and the pure SCS matrix demonstrated a significant reduction in bacterial proliferation of both S. aureus and E. coli.

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Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Cited by 32 publications

References 223 publications

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Chitosan Hydrogels for Water Purification Applications

Multilayer Electrospun Scaffolds of Opposite-Charged Chitosans

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