Fabrication of heparinized nano ZnO/poly(vinylalcohol)/carboxymethyl cellulose bionanocomposite hydrogels using artificial neural network for wound dressing application

Joorabloo, Alireza; Khorasani, Mohammad Taghi; Adeli, Hassan; Mansoori-Moghadam, Zohreh; Moghaddam, Armaghan

doi:10.1016/j.jiec.2018.10.022

Cited by 80 publications

(26 citation statements)

References 35 publications

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“…There are also several hydrogels that are designed from cellulose and its derivatives for wound application ( Table 1 ). Joorabloo formulated carboxymethyl cellulose-based hydrogels loaded with heparinized zinc oxide nanoparticle via a freeze–thaw method for application in wound dressing [ 125 ]. The average particle size of the loaded ZnO nanoparticles ranged between 16 and 36 nm.…”

Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

“…The mechanical properties of hydrogels increased with an increase in the amount of nanoparticles loaded into the hydrogel. The mechanical strength and Young’s modulus increased while the elongation at breakpoint decreased [ 125 ]. Cell viability study of hydrogels loaded with nanoparticles demonstrated non-toxicity on HDF and L-929 cells after 2 days.…”

Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

“…Cell viability study of hydrogels loaded with nanoparticles demonstrated non-toxicity on HDF and L-929 cells after 2 days. The wound healing assessment studies revealed good wound healing capability on the created artificial wound after 24 h. The antibacterial activity of the hydrogels using disc diffusion method showed significant bactericidal efficacy of over 70% for ZnO-loaded hydrogels against S. aureus and E. coli [ 125 ].…”

Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

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Chitosan and Cellulose-Based Hydrogels for Wound Management

Alven

Aderibigbe

2020

IJMS

200

111

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Wound management remains a challenge worldwide, although there are several developed wound dressing materials for the management of acute and chronic wounds. The wound dressings that are currently used include hydrogels, films, wafers, nanofibers, foams, topical formulations, transdermal patches, sponges, and bandages. Hydrogels exhibit unique features which make them suitable wound dressings such as providing a moist environment for wound healing, exhibiting high moisture content, or creating a barrier against bacterial infections, and are suitable for the management of exuding and granulating wounds. Biopolymers have been utilized for their development due to their non-toxic, biodegradable, and biocompatible properties. Hydrogels have been prepared from biopolymers such as cellulose and chitosan by crosslinking with selected synthetic polymers resulting in improved mechanical, biological, and physicochemical properties. They were useful by accelerating wound re-epithelialization and also mimic skin structure, inducing skin regeneration. Loading antibacterial agents into them prevented bacterial invasion of wounds. This review article is focused on hydrogels formulated from two biopolymers—chitosan and cellulose—for improved wound management.

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Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

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Chitosan and Cellulose-Based Hydrogels for Wound Management

Alven

Aderibigbe

2020

IJMS

200

111

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“…In this study, heparin may have anti‐inflammatory and growth factor roles in the wound healing process. [ 19 ] In another study, sodium montmorillonite at 5%wt amount was used due to improving mechanical properties of ZnONPs/CMC nanofilm (NF). Antibacterial activities of this NF were more against S. aureus (inhibition zone diameter [IZD] = 20.4 mm) compared to E. coli (18.4 mm).…”

Section: Carboxymethyl Cellulosementioning

confidence: 99%

Antimicrobial and Wound Treatment Aspects of Micro‐ and Nanoformulations of Carboxymethyl, Dialdehyde, and TEMPO‐Oxidized Derivatives of Cellulose: Recent Advances

Alavi

Nokhodchi

2020

Macromolecular Bioscience

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/mabi.201900362.The remedy for infected chronic wounds such as diabetic foot ulcers is more complicated particularly in the case of patients with an inefficient immune system. Also, fighting against microbial infections in the wound site by available antibiotics may not be effective because of emerging antibiotic resistance properties among pathogenic bacteria and fungi. Recently, applications of micro-and nanoformulations of biomaterials have demonstrated improved therapeutic abilities for wound dressings. In this way, carboxymethyl, dialdehyde, and 2,2,6,6-tetramethylpiperidine-1-oxyl-oxidized celluloses are common biomaterials having outstanding physicochemical and therapeutic properties compared to unmodified cellulose. Therefore, in this review, recent progress in the field of wound healing and antimicrobial activities of these derivatives are presented and discussed.

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“…Owing to its good film forming ability, long-term temperature and pH stability; PVA-based hydrogels find a greater call in biomedical research [33][34][35][36]. Several studies have reported the successful design of PVA/CMC hydrogels for potential applications in medicine [23,[37][38][39][40][41][42]. Literature also points towards the utilities of the aforesaid hydrogels in agriculture, dye removal and other industrial areas [43][44][45][46][47][48][49][50][51][52].…”

Section: Introductionmentioning

confidence: 99%

Cold atmospheric plasma surface nanoengineered carboxymethyl cellulose hydrogels as oral ibuprofen carriers

et al. 2019

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Smart hydrogels comprising polyvinyl alcohol and carboxymethyl cellulose have been fabricated using a green crosslinker tetraethyl orthosilicate. The hydrogels were subjected to cold atmospheric plasma-treatment using pure Ar, pure NH 3 and a mixture of the two. Enhanced surface wettability was witnessed post-plasma treatment; irrespective of the plasma gas employed. An insignificant surface ageing of the hydrogels was marked upon exposure to air for 10 days. AFM analyses revealed the surface topographical changes at the nano level while the bulk attributes remained unaffected. The hydrogels displayed smart swelling features. The release of ibuprofen from the hydrogels in simulated gastric and intestinal fluids affirmed their potential towards oral colon-targeted drug delivery. The preliminary kinetics of drug release indicated the anomalous nature of drug transport mechanism. More so, drug release from plasma-treated hydrogels were predominantly governed by diffusion process rather than polymer chain relaxational process. The hydrogels demonstrated good biodegradability and could be efficaciously utilized as potential oral drug delivery candidates.

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Fabrication of heparinized nano ZnO/poly(vinylalcohol)/carboxymethyl cellulose bionanocomposite hydrogels using artificial neural network for wound dressing application

Cited by 80 publications

References 35 publications

Chitosan and Cellulose-Based Hydrogels for Wound Management

Chitosan and Cellulose-Based Hydrogels for Wound Management

Antimicrobial and Wound Treatment Aspects of Micro‐ and Nanoformulations of Carboxymethyl, Dialdehyde, and TEMPO‐Oxidized Derivatives of Cellulose: Recent Advances

Cold atmospheric plasma surface nanoengineered carboxymethyl cellulose hydrogels as oral ibuprofen carriers

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