Fabrication of Curcumin Loaded Nano Polycaprolactone/Chitosan Nonwoven Fabric via Electrospinning Technique

Hoang, Minh Hien

doi:10.15625/2525-2518/55/1b/12097

Cited by 10 publications

(5 citation statements)

References 10 publications

(10 reference statements)

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“…As already shown in the photographic images of the blend fibers, free droplets are observed around the fiber mat containing 10 wt% Cur. A similar trend was observed for the diameter of curcumin-loaded PCL/chitosan [30], polyurethane [20] and cellulose acetate [14] fibers. The resultant thicker fibers with the addition of curcumin were attributed to the higher viscosity of the electrospinning solution and lower solvent evaporation rate.…”

Section: Effect Of Pu and Cur Concentrationsupporting

confidence: 82%

“…Fallah et al [32] showed that PCL/gelatin/curcumin nanofibers have an increasing diameter with the increasing voltage ranging from 10 to 20 kV. In another example, Hoang et al [30] reported the increased diameter of PCL/chitosan fibers with respect to the applied voltage (15,18, and 24 kV), pointing out the higher electrostatic force results in the multi-jet formation, hence the multiple fibers can stick each other and form thicker fibers. It can be noted that applied voltage affects not only the fiber diameter but also the hydrophilicity of the fibers, as shown by the contact angle values.…”

Section: Effect Of Electrospinning Parameters On the Pu/cur Fibersmentioning

confidence: 99%

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Kurkumin Yüklü Biyo-Bazlı Elektroeğirme Poliüretan Yapılar

Horzum

Kinali

2019

Cumhuriyet Science Journal

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Polymeric electrospun fibers present well-design scaffolds for wound healing applications. Here, the fabrication of biobased polyurethane (PU) blend fibers containing curcumin (Cur) was reported. Not only polymer concentration but also curcumin concentration affects the morphology, diameter, and contact angle values of the fibers. Morphological investigations revealed that the diameter and hydrophilicity of the PU fibers increased upon addition of curcumin. Effect of process parameters (applied voltage, flow rate, and tipto-collector distance) on the average diameter and the hydrophilicity of the PU and PU/Cur fibers were examined. Optimum conditions to obtain uniform and bead-free PU/Cur fibers were determined as 12.5 kV, 1 mL/h, and 17 cm. This study demonstrates that the electrospinning process provides a simple way of obtaining bioactive agent loaded fibrous scaffolds, as well as contributing to a better understanding of the effect of process variables in the fabrication of PU/Cur blend fibers for wound healing applications.

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Section: Effect Of Pu and Cur Concentrationsupporting

confidence: 82%

Section: Effect Of Electrospinning Parameters On the Pu/cur Fibersmentioning

confidence: 99%

Kurkumin Yüklü Biyo-Bazlı Elektroeğirme Poliüretan Yapılar

Horzum

Kinali

2019

Cumhuriyet Science Journal

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“…Minh Son Hoang and co-authors 27 successfully obtained curcumin-loaded polycaprolactone/chitosan (PCL/CTS) nanofibers which have a diameter range from 267 nm to 402 nm. The authors analyzed in detail the physical characteristics of PCL/CTS spinning polymer solutions, as well as the effect of the technological parameters on solution electrospinnability and fiber morphology.…”

Section: Polymers Used For Curcumin-loaded Fiber Formationmentioning

confidence: 99%

Electrospun curcumin-loaded polymer nanofibers: solution recipes, process parameters, properties, and biological activities

et al. 2022

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“…More curcumin would be expected to release with a specific rate from higher concentrations, such as 17% curcumin loaded poly (εcaprolactone) (PCL) nanofibers than the lower concentrations, such as 3% curcumin loaded PCL nanofibers, after 12 h (as shown in figure 2(b)) [30]. Using PCL-curcumin solutions, biofunctional electrospun nanofibers were prepared [30][31][32][33]68]. Hoang et al [68] fabricated curcumin loaded PCL/chitosan nonwoven mats (for wound dressings) using formic acid and acetone together as solvents while electrospinning nanofibers.…”

Section: Introductionmentioning

confidence: 99%

“…Using PCL-curcumin solutions, biofunctional electrospun nanofibers were prepared [30][31][32][33]68]. Hoang et al [68] fabricated curcumin loaded PCL/chitosan nonwoven mats (for wound dressings) using formic acid and acetone together as solvents while electrospinning nanofibers. They also investigated the release of curcumin (via an in vitro approach) from nonwoven mats of these fibers (having fiber diameters in the range between 267 nm to 402 nm); it was found to be nearly 80% during the initial 100 h. The gelatin nanofibers were found to serve as vehicles to release the drugs in controlled manner.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning process parameters optimization for biofunctional curcumin/gelatin nanofibers

Kanu

Gupta

Vates

et al. 2020

Mater. Res. Express

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Electrospinning has received wide attention for the preparation of uniform diameter nanofibers (ranging from 5 nm to several hundred nanometers) in films with random as well as aligned fashions of the fibers of various materials for use in biomedical applications. Electrospinning research has provided an in-depth understanding of the preparation of light weight, ultrathin, porous, biofunctional curcumin/gelatin nanofibers having applications in wound dressing, drug release, tissue engineering, etc. In the first half of this article, prior research on electrospun curcumin/gelatin nanofibers is reviewed in depth with nanofibers being desired due to their low diameters since these would have then large surface area to volume ratio and enough film porosity as well as improved mechanical (tensile) strength so that when prepared as mats these nanofibers (having high biocompatibility) could be used for sustained release of curcumin and oxygen to wounds during healing. The synthesis of ultrathin nanofibers (having minimum average diameter) is not a simple task unless numerical investigation is carefully done in the first half of this research article. The authors research described here examined the effects of critical process parameters (in the second half of the paper) such as distance between the spinneret and collector, flow rate, voltage and solution viscosity, on the preparation of uniform and ultrathin nanofibers using scanning electron microscopy (SEM) for characterization of the nanofibers. A 2 k factorial design of experiment was found to be a suitable and efficient technique to optimize the critical process parameters used in the preparation of the biofunctional nanofibers with the purpose of having applications in the treatment of problematic wounds such as diabetic chronic ulcers. After parametric investigation, the distance, flow rate and voltage when taken together, were found to have the most significant contributions to the preparation of minimum diameter nanofibers. The primary objective of this research was fulfilled with the development of ultrathin curcumin/gelatin nanofibers having a 181 nm (181±66 nm) average diameter using the optimized setting of a solution having 1.5% gelatin, and 1% curcumin in 10 ml of 98% concentrated formic acid, with the electrospining unit having a voltage of 10 KV, distance from the spinneret to collector drum of 15 cm, flow rate of 0.1 ml h −1 , viscosity of 65 cP and drum collector speed of 1000 rpm. However, the lowest average diameter of nanofiber was measured around 147 nm (147±34 nm) which was prepared at a higher voltage, such as 15 KV (at 10 cm distance, 0.15 ml h −1 flow rate and 65 cP viscosity) using the solution. The design of this research paper is based on the view that merely optimization of biofunctional nanofibers may not fully satisfy researchers/ engineers unless they are also provided with sufficient information about (a) the entire electrospinning mechanism (numerical investigations of the mechanism) to have better control over preparation of ultr...

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Fabrication of Curcumin Loaded Nano Polycaprolactone/Chitosan Nonwoven Fabric via Electrospinning Technique

Cited by 10 publications

References 10 publications

Kurkumin Yüklü Biyo-Bazlı Elektroeğirme Poliüretan Yapılar

Kurkumin Yüklü Biyo-Bazlı Elektroeğirme Poliüretan Yapılar

Electrospun curcumin-loaded polymer nanofibers: solution recipes, process parameters, properties, and biological activities

Electrospinning process parameters optimization for biofunctional curcumin/gelatin nanofibers

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