Kurkumin Yüklü Biyo-Bazlı Elektroeğirme Poliüretan Yapılar

Abstract

Polymeric electrospun fibers present well-design scaffolds for wound healing applications. Here, the fabrication of biobased polyurethane (PU) blend fibers containing curcumin (Cur) was reported. Not only polymer concentration but also curcumin concentration affects the morphology, diameter, and contact angle values of the fibers. Morphological investigations revealed that the diameter and hydrophilicity of the PU fibers increased upon addition of curcumin. Effect of process parameters (applied voltage, flow rate, and tipto-collector distance) on the average diameter and the hydrophilicity of the PU and PU/Cur fibers were examined. Optimum conditions to obtain uniform and bead-free PU/Cur fibers were determined as 12.5 kV, 1 mL/h, and 17 cm. This study demonstrates that the electrospinning process provides a simple way of obtaining bioactive agent loaded fibrous scaffolds, as well as contributing to a better understanding of the effect of process variables in the fabrication of PU/Cur blend fibers for wound healing applications.

Electrospun curcumin-loaded polymer nanofibers: solution recipes, process parameters, properties, and biological activities

“…Horzum Polat with coauthors 40 obtained electrospun nanofibers based on biobased PU Pearlthane® ECO D12T85. Special attention was given to an optimization of the electrospinning process by varying technological parameters (applied voltage, flow rate, and the distance between the spinneret and collector), as well as solution recipes.…”