Fabrication of core–shell nanofibers by single capillary electrospinning combined with vapor induced phase separation

Jiang, Yifeng; Fang, Dawei; Song, Guoqiang; Nie, Jun; Chen, Binling; Ma, Guiping

doi:10.1039/c3nj00654a

Cited by 30 publications

(16 citation statements)

References 23 publications

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“…Since the first report of drug-loaded nanofibers fabricated using electrospinning [ 1 ], these materials have been widely explored in the biomedical field [ 2 - 5 ]. As the electrospinning processes reported in the literature have become more complex, advancing from single-fluid to multiple-fluid processes [ 6 - 8 ], the nanofibers thereby produced have correspondingly evolved from monolithic nanofibers to core-shell structures, side-by-side nanofibers, and nanofibers containing particles or with a high porosity [ 9 - 11 ]. Current research is exploring how the electrospinning process could be scaled up from the laboratory to the industrial scale [ 12 , 13 ] and looking to improve the homogeneity and quality of the fiber populations generated [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process

Wang

et al. 2014

Nanoscale Res Lett

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This manuscript reports a new type of drug-loaded core-shell nanofibers that provide tunable biphasic release of quercetin. The nanofibers were fabricated using a modified coaxial electrospinning process, in which a polyvinyl chloride (PVC)-coated concentric spinneret was employed. Poly (vinyl pyrrolidone) (PVP) and ethyl cellulose (EC) were used as the polymer matrices to form the shell and core parts of the nanofibers, respectively. Scanning and transmission electron microscopy demonstrated that the nanofibers had linear morphologies and core-shell structures. The quercetin was found to be present in the nanofibers in the amorphous physical status, on the basis of X-ray diffraction results. In vitro release profiles showed that the PVP shell very rapidly freed its drug cargo into the solution, while the EC core provided the succedent sustained release. Variation of the drug loading permitted the release profiles to be tuned.

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Section: Introductionmentioning

confidence: 99%

Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process

Wang

et al. 2014

Nanoscale Res Lett

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“…The core–shell structure with a sharp interface was retained after water treatment. The reason for the generation of core–shell nanofibers could be as follows: The PVP component was driven toward the fiber exterior during the electrospinning process because of the attraction of the low surface energy, which was the key factor in forming the core–shell structure [40,41]. The high fraction of acetone allowed for the high mobility of the CA polymer chains, which caused a large-scale continuous phase of the CA component to form the core structure, thereby generating a phase separation.…”

Section: Resultsmentioning

confidence: 99%

Biomimetic Growth of Hydroxyapatite on Electrospun CA/PVP Core–Shell Nanofiber Membranes

et al. 2018

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In this study, cellulose acetate (CA)/polyvinylpyrrolidone (PVP) core–shell nanofibers were successfully fabricated by electrospinning their homogeneous blending solution. Uniform and cylindrical nanofibers were obtained when the PVP content increased from 0 to 2 wt %. Because of the concentration gradient associated with the solvent volatilization, the composite fibers flattened when the PVP increased to 5 wt %. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) results confirmed the existence of a hydrogen bond between the CA and PVP molecules, which enhanced the thermodynamic properties of the CA/PVP nanofibers, as shown by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) results. To analyze the interior structure of the CA/PVP fibers, the water-soluble PVP was selectively removed by immersing the fiber membranes in deionized water. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicated that the PVP component, which has a low surface tension, was driven to the exterior of the fiber to form a discontinuous phase, whereas the high-content CA component inclined to form the internal continuous phase, thereby generating a core–shell structure. After the water-treatment, the CA/PVP composite fibers provided more favorable conditions for mineral crystal deposition and growth. Energy-dispersive spectroscopy (EDS) and FTIR proved that the crystal was hydroxyapatite (HAP) and that the calcium to phosphorus ratio was 1.47, which was close to the theoretical value of 1.67 in HAP. Such nanofiber membranes could be potentially applicable in bone tissue engineering.

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“…Figure shows the schematic illustration of the experimental processes to prepare polymer core–shell fibers, hollow fibers, and polymer microbowls. The polymer core–shell fibers are prepared by the single axial electrospinning technique using polymer blend solutions . A PS/PMMA blend solution (weight ratio = 1:1) is first prepared and added into a syringe.…”

Section: Resultsmentioning

confidence: 99%

Plateau–Rayleigh Instability Morphology Evolution (PRIME): From Electrospun Core–Shell Polymer Fibers to Polymer Microbowls

Chiu

Tseng

et al. 2017

Macromol. Rapid Commun.

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Electrospun core-shell fibers have great potentials in many areas, such as tissue engineering, drug delivery, and organic solar cells. Although many core-shell fibers have been prepared and studied, the morphology transformation of core-shell fibers have been rarely studied. In this work, the morphology evolution of electrospun core-shell polymer fibers driven by the Plateau-Rayleigh instability is investigated. Polystyrene/poly(methyl methacrylate) (PS/PMMA) core-shell fibers are first prepared by using blend solutions and a single axial electrospinning setup. After PS/PMMA core-shell fibers are annealed on a PS film, the fibers undulate and sink into the polymer film, forming core-shell hemispheres. The evolution process, which can be observed in situ by optical microscopy, is mainly driven by achieving lower surface and interfacial energies. The morphologies of the transformed structures can be confirmed by a selective removal technique, and polymer microbowls can be obtained.

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Fabrication of core–shell nanofibers by single capillary electrospinning combined with vapor induced phase separation

Cited by 30 publications

References 23 publications

Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process

Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process

Biomimetic Growth of Hydroxyapatite on Electrospun CA/PVP Core–Shell Nanofiber Membranes

Plateau–Rayleigh Instability Morphology Evolution (PRIME): From Electrospun Core–Shell Polymer Fibers to Polymer Microbowls

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