Fabrication of core–shell microcapsules using PLGA and alginate for dual growth factor delivery system

Choi, Dong Hoon; Park, Chul Ho; Kim, Ik Hwan; Chun, Heung Jae; Park, Kwideok; Han, Dong Keun

doi:10.1016/j.jconrel.2010.07.103

Cited by 114 publications

(79 citation statements)

References 26 publications

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“…Most of the scaffolds were built on complex constructs of several composition and additives. Natural polymer such as chitosan, alginate or gelatin [15][16][17] or synthetic polymer such as poly lactic acid (PLA), poly glycolic acid(PGA) an poly lactic -co-glycolic acid (PLGA) are widely used for polymer scaffold. However, some drawbacks still exist upon using polymers including: formation of acidic species, this leads to a decrease in pH and tissue inflammation [18,19].…”

Section: Introductionmentioning

confidence: 99%

Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds

Mabrouk

Mostafa

Oudadesse

et al. 2014

Ceramics International

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Scaffolds are implants used to deliver cells, drugs, and genes into the body in a local controlled release pattern which offers many advantages over systematic drug delivery. Composite scaffolds of polyvinyl alcohol (PVA) and quaternary bioactive glass (46S6 system) with different ratios of glass contents were prepared by lyophilisation technique. The broad spectrum antibiotic ciprofloxacin (Cip) was impregnated to the scaffold during the fabrication in a concentration of 5, 10 and 20%. Biodegradation rate and in-vitro mineralization of the prepared scaffolds were performed by soaking the scaffolds in simulated body fluid (SBF). Phase identification, microstructure, porosity, bioactivity, mechanical properties and drug release pattern in PBS were characterized by XRD, SEM coupled with EDS, Hg-porosimeter, inductively coupled plasma-optical emission spectroscopy (ICP-OES), universal testing machine, fourier transform infrared (FTIR) and UV-spectrophotometer, respectively. A porous scaffold has been obtained with porosity up to 85%. By increasing the glass contents in the prepared scaffold the porosity and the degradation rate decrease however, the compressive strength was enhanced. A sustained drug release pattern was observed with a quasi-Fickian diffusion mechanism. The formulated ciprofloxacin loaded porous polyvinyl alcohol scaffold gave an acceptable physicochemical properties and was able to deliver the drug in a prolonged release pattern which offers a distinguish treatment for osteomylitis as well as local antibacterial effect.

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Section: Introductionmentioning

confidence: 99%

Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds

Mabrouk

Mostafa

Oudadesse

et al. 2014

Ceramics International

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“…15 Core-shell microspheres have been developed to encapsulate bovine serum albumin (BSA),12 etanidazole, 16 doxorubicin, 17 5-fluorouracil, 18 and piroxicam, 19 etc. These core-shell microspheres, to some extent, improve and extend the in vitro release profiles and release period of these compounds.…”

Section: Introductionmentioning

confidence: 99%

Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres

Yuan¹,

Liu²

2012

IJN

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Abstract:In order to address preserved protein bioactivities and protein sustained-release problems, a method for preparing double-walled microspheres with a core (protein-loaded nanoparticles with a polymer-suspended granule system-formed core) and a second shell (a polymerformed shell) for controlled drug release and preserved protein bioactivities has been developed using (solid-in-oil phase-in-hydrophilic oil-in-water (S/O/O h /W)) phases. The method, based on our previous microsphere preparation method (solid-in-oil phase-in-hydrophilic oil-in-water (S/O/O h /W), employs different concentric poly(D,L-lactide-co-glycolide), poly(D,L-lactide), and protein-loaded nanoparticles to produce a suspended liquid which then self-assembles to form shell-core microspheres in the hydrophilic oil phase, which are then solidified in the water phase. Variations in the preparation parameters allowed complete encapsulation by the shell phase, including the efficient formation of a poly(D,L-lactide) shell encapsulating a protein-loaded nanoparticle-based poly(D,L-lactide-co-glycolide) core. This method produces core-shell doublewalled microspheres that show controlled protein release and preserved protein bioactivities for 60 days. Based upon these results, we concluded that the core-shell double-walled microspheres might be applied for tissue engineering and therapy for chronic diseases, etc.

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“…41 More recently, these polymers have been used as coating materials to make polyelectrolyte multilayer-charged PLGA NPs, 42 and to achieve cohesive colloidal gels as scaffold in tissue engineering, 43 such as to construct composite microspheres. 44 It is a consistent opinion that the future for efficient RSV delivery lies in the development of innovative formulation strategies able to overcome each of the physicochemical, pharmacokinetic, and metabolic limitations that characterize this compound. 19 In this study, we examined the feasibility of encapsulating RSV into PLGA NPs coated on the surface with cationic and anionic polymers (Figure 1), in order to obtain suitable drug carriers able to combine protection and controlled release.…”

Section: Introductionmentioning

confidence: 99%

Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

Sanna¹,

Roggio²,

Siliani³

et al. 2012

IJN

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Background:Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may be achieved via suitable carriers able to associate controlled release and protection. In this context, nanotechnology is proving to be a powerful strategy. In this study, we developed novel cationic chitosan (CS)-and anionic alginate (Alg)-coated poly(d,l-lactide-co-glycolide) nanoparticles (NPs) loaded with the bioactive polyphenolic trans-(E)-resveratrol (RSV) for biomedical applications. Methods: NPs were prepared by the nanoprecipitation method and characterized in terms of morphology, size and zeta potential, encapsulation efficiency, Raman spectroscopy, swelling properties, differential scanning calorimetry, and in vitro release studies. The protective effect of the nanosystems under the light-stressed RSV and long-term stability were investigated. Results: NPs turned out to be spherical in shape, with size ranging from 135 to about 580 nm, depending on the composition and the amount of polyelectrolytes, while the encapsulation efficiencies increased from 8% of uncoated poly(d,l-lactide-co-glycolide) (PLGA) to 23% and 32% of Alg-and CS-coated PLGA NPs, respectively. All nanocarriers are characterized by a biphasic release pattern, and more effective controlled release rates are obtained for NPs formulated with higher polyelectrolyte concentrations. Stability studies revealed that encapsulation provides significant protection against light-exposure degradation, by reducing the trans-cis photoisomerization reaction. Moreover, the nanosystems are able to prevent the degradation of trans isoform and the leakage of RSV from the carrier for a period of 6 months. Conclusion: Our findings indicated that the newly developed CS-and Alg-coated PLGA NPs are suitable to be used for the delivery of bioactive RSV. The encapsulation of RSV into optimized polymeric NPs provides improved drug loading, effective controlled release, and protection against light-exposure degradation, thus opening new perspectives for the delivery of bioactive related phytochemicals to be used for (nano)chemoprevention/chemotherapy.

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Fabrication of core–shell microcapsules using PLGA and alginate for dual growth factor delivery system

Cited by 114 publications

References 26 publications

Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds

Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds

Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres

Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

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Fabrication of core–shell microcapsules using PLGA and alginate for dual growth factor delivery system

Cited by 114 publications

References 26 publications

Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds

Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds

Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres

Development of novel cationic chitosan- and anionic alginate&ndash;coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol

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Resources

About

Development of novel cationic chitosan- and anionic alginate–coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol