Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds

Abstract

Scaffolds are implants used to deliver cells, drugs, and genes into the body in a local controlled release pattern which offers many advantages over systematic drug delivery. Composite scaffolds of polyvinyl alcohol (PVA) and quaternary bioactive glass (46S6 system) with different ratios of glass contents were prepared by lyophilisation technique. The broad spectrum antibiotic ciprofloxacin (Cip) was impregnated to the scaffold during the fabrication in a concentration of 5, 10 and 20%. Biodegradation rate and in-vitro mineralization of the prepared scaffolds were performed by soaking the scaffolds in simulated body fluid (SBF). Phase identification, microstructure, porosity, bioactivity, mechanical properties and drug release pattern in PBS were characterized by XRD, SEM coupled with EDS, Hg-porosimeter, inductively coupled plasma-optical emission spectroscopy (ICP-OES), universal testing machine, fourier transform infrared (FTIR) and UV-spectrophotometer, respectively. A porous scaffold has been obtained with porosity up to 85%. By increasing the glass contents in the prepared scaffold the porosity and the degradation rate decrease however, the compressive strength was enhanced. A sustained drug release pattern was observed with a quasi-Fickian diffusion mechanism. The formulated ciprofloxacin loaded porous polyvinyl alcohol scaffold gave an acceptable physicochemical properties and was able to deliver the drug in a prolonged release pattern which offers a distinguish treatment for osteomylitis as well as local antibacterial effect.

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

“…In general, according to the quasi‐Fickian diffusion mechanism drug transport mechanism from macromolecular polymers, Gel, as a hydrogel, is able to form a swollen matrix in a hydrolytic media, which helps to release drugs at a slow and constant rate . However, CIP release with a relatively controlled rate from CIP‐M 11 would be mainly because of the interaction between functional groups of CIP and polymeric mat (Gel polypeptides and PGS), which causes the creation of a three‐dimensional structure that provides a suitable sustained release over time . Based on the three obtained results, it seems to be logical that CIP‐M 11 and M 5 samples (1Seb:1Gly) are considered for the next characterization tests.…”

Effect of Dual Releasing of β-glycerophosphate and Dexamethasone from Ti Nanostructured Surface for Using in Orthopedic Applications

“…The two peaks in the ranges 978 cm -1 and 1074 cm -1 in DEX and GP correspond with the stretching vibration of P-O-C groups [35]. In pure PVA, the peak in the range of 500-900 cm -1 is related to the main structure of the alkyl group presented in the polyvinyl alcohol structure [36]. The presence of broad and severe peaks in the mentioned range in the TNT-GD sample represents the overlapping of these peaks.…”

Poly (vinyl alcohol)/chitosan cryogels as PH responsive ciprofloxacin carriers

“…The main characteristic bands of CF are: 3530, 1704, 1623, 1046 cm −1 which are atributted to O-H stretching vibration, C = O stretching vibration, C = C stretching vibration and C-F stretching vibration, respectively [33]. For piperazine, the strong CH stretching bands have been assigned to the bands at wavenumbers 3084, 2911, 2688 and 2620 cm −1 [34].…”