Poly (vinyl alcohol)/chitosan cryogels as PH responsive ciprofloxacin carriers

Pamfil, Daniela; Brebu, Mihai; Vasile, Cornelia

doi:10.1007/s10965-016-1042-1

Cited by 16 publications

(2 citation statements)

References 46 publications

(43 reference statements)

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“…The variation of the kinetic parameter values is asociated with the p K a values of the components and their interactions by functional groups, as was demonstrated for other pH-responsive systems [ 62 , 63 , 64 , 65 , 66 ], and in this case those of MTX and HA.…”

Section: Resultsmentioning

confidence: 52%

Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy

et al. 2017

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Poly(vinyl alcohol)/hyaluronic acid cryogels loaded with methotrexate were studied. The physical-chemical characterization of cryogels was performed by FT-IR spectroscopy, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical thermal analysis. Acute toxicity and haematological parameters were determined by "in vivo" tests. The biocompatibility tests proved that the obtained cryogels showed significantly decreased toxicity and are biocompatible. The pH-responsiveness of the swelling behaviour and of the methotrexate release from the poly(vinyl alcohol)/hyaluronic acid (PVA/HA) cryogels were studied in a pH interval of 2-7.4. A significant change in properties was found at pH 5.5 specific for treatment of affected skin in psoriasis disease.

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Section: Resultsmentioning

confidence: 52%

Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy

et al. 2017

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“…Zupanc ˇic ˇet al 14 reported that thicker nanofibers can reduce the bacterial cell mobility more profusely and quickly than thinner fibers as the response was cell-line specific. 15,16 Therefore, nanofibers can exhibit strong inhibition performance and be used as antibacterial agents 17,18 in drug delivery, 19,20 tissue engineering, [21][22][23] bio-adhesive, 20 and filtration.…”

Section: Introductionmentioning

confidence: 99%

Forcespun polyvinylpyrrolidone/copper and polyethylene oxide/copper composite fibers and their use as antibacterial agents

Hasan

Gonzalez

Munoz

et al. 2021

J of Applied Polymer Sci

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Copper nanoparticles (CuNPs) embedded in polyvinylpyrrolidone (PVP) and polyethylene oxide (PEO) fiber-matrices were prepared through centrifugal spinning of PVP/ethanol and PEO/aqueous solutions, respectively. The prime focus of the current study is to investigate the antibacterial activity of composite fibers against Escherichia coli (E. coli) and Bacillus cereus (B. cereus) bacteria. During the fiber formation, the centrifugal spinning parameters such as spinneret rotational speed, spinneret to collector distance, and relative humidity were carefully chosen to obtain long and continuous fibers. The structural and morphological analyses of both composite fibers were investigated using scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, and thermogravimetric analysis. In the antibacterial test, PVP/Cu and PEO/Cu composite fibrous membranes exhibited inhibition efficiency of 99.98% and 99.99% against E. coli and B. cereus bacteria, respectively. Basically, CuNPs were well embedded in the fibrous membrane at the nanoscale level, which facilitated the inhibition of bacterial functions through the inactivation of the chemical structure of the cells. Such an effective antibacterial agent obtained from forcespun composite fibers could be promising candidates for biomedical applications.

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