Fabrication of chelate-setting cement from hydroxyapatite powder prepared by simultaneously grinding and surface-modifying with sodium inositol hexaphosphate and their material properties

Abstract

We have previously developed hydroxyapatite (HAp) cement based on the chelate-setting mechanism of sodium inositol hexaphosphate (IP6-Na). In the present study, the effect of the IP6-Na concentration on material properties, such as compressive strength, setting time, consistency, and anti-washout capability, of the chelate-setting hydroxyapatite cement was investigated with the aim to develop paste-like artificial bone with anti-washout capability. Starting powders for cement fabrication (IP6-HAp powder) were prepared by simultaneous grinding and surface-modification of the HAp powder in various concentrations (0 20000 ppm) of IP6-Na solution. The amount of IP6 adsorbed on the surface of the HAp powders increased with the IP6-Na concentration and resulted in a negative charge on the powder surface. Dispersion of the IP6-HAp powder was improved with increasing IP6-Na concentration. A workable cement paste was prepared from the negatively charged IP6-HAp powder (<¹20 mV) at a higher powder/liquid ratio, regardless of the low water content. The compressive strength of the resulting cement specimens increased from 1.4 to 8.3 MPa with an increase of the relative density. HAp powders surface-modified with 5000 to 10000 ppm IP6-Na are effective for fabrication of IP6-HAp cements with enhanced material properties. In particular, surfacemodification with 5000 and 10000 ppm IP6-Na improved the handling feasibility of the cement paste. IP6-HAp cement fabricated by controlling the IP6-Na concentration is promising as an injectable artificial bone for minimally-invasive treatment.

Fabrication of Novel Biodegradable α‐Tricalcium Phosphate Cement Set by Chelating Capability of Inositol Phosphate and Its Biocompatibility

“…We have developed a novel CPC using inositol phosphate (C 6 H 6 (OPO 3 H 2 ) 6 ; IP6) as a chelating agent [8][9][10][11]. IP6 is found in wheat, rice, corn, and soybean [12], and it has a strong chelating capability to calcium ions, similar to chelating compounds such as ethylenediaminetetraacetic Journal of Nanomaterials acid (EDTA) [13].…”

EFFECTS OF ADDITION OF Α-Tricalcium PHOSPHATE POWDERS ON MATERIAL PROPERTIES OF THE CHELATE-SETTING HYDROXYAPATITE CEMENT

“…In order to enhance paste-like feature and anti-washout capability of the chelate-setting IP6-HAp cement, surface modification process of the HAp powders with IP6 was recently modified 5 . In the new process, the cement powders were prepared by simultaneous grinding and surface modification of the HAp powders in various concentrations (1,000-20,000 ppm) of the IP6 solution 6 .…”

Preparation of α-Tricalcium Phosphate Powders Surface-Modified with Inositol Phosphate for Cement Fabrication

“…The starting cement powder for the cement fabrication was prepared by surface-modification with IP6 after ball-milling of the HAp powder [5]. In the recent study, we have established a novel powder preparation process for the cement fabrication, in which the starting HAp powders were prepared by simultaneous ball-milling and surface-modification of the HAp powders in the IP6 solution [8]. Meanwhile, one of the clinical problems of HAp is long-term existence in implanted site [9], hence biodegradable calcium phosphate, α-tricalcium phosphate (α-TCP), is more attractive compared to the HAp.…”