Fabrication of Apigenin loaded gellan gum–chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing

Shukla, Rajesh; Kashaw, Sushil K.; Jain, Alok Pal; Lodhi, Santram

doi:10.1016/j.ijbiomac.2016.06.075

Cited by 105 publications

(41 citation statements)

References 39 publications

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“…Moreover, these data correlate with in vivo results disclosed by other authors using formulations containing chitosan(Gopal, Kant, Gopalakrishnan, Tandan, & Kumar, 2014;Karri et al, 2016).In recent years, different studies regarding the effects of flavonoid-rich plant extracts or formulations containing flavonoids combined with biomaterials on wound care have been developed Garros et al (2006). reported that topical use of P. edulis leaf extract led to increased fibroblast proliferation and improved reepithelization on the seventh postoperative day in Wistar rats Shukla, Kashaw, Jain, and Lodhi (2016). demonstrated that reticulated chitosan gel, gellan gum, and apigenin accelerated contraction of the wound in diabetic rats after 14 days of treatment Karri et al (2016).…”

supporting

confidence: 78%

“…The authors agree with other studies(Chu, Yu, Amidon, Weiner, & Goldberg, 1992;Islam, Rodríguez-Hornedo, Ciotti, & Ackermann, 2004;Pillai, Paul, & Sharma, 2009) in that the presence of glycerin may have also helped to maintain the stability of the formulation due to the formation of hydrogen bonds.According to the Alamar Blue test, we observed that the formulations HC and HCF were not cytotoxic. reported that topical use of P. edulis leaf extract led to increased fibroblast proliferation and improved reepithelization on the seventh postoperative day in Wistar rats Shukla, Kashaw, Jain, and Lodhi (2016). The Alamar Blue test is a very popular method, and over the last 50 years it has been widely used in cell viability and cytotoxicity studies due to its speed, sensitivity, and reduced cost(Damiani, Solorio, Doyle, & Wallace, 2019; Tahara et al, 2017).…”

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confidence: 99%

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Development of a chitosan hydrogel containing flavonoids extracted from Passiflora edulis leaves and the evaluation of its antioxidant and wound healing properties for the treatment of skin lesions in diabetic mice

Soares

Campos

Ribeiro

et al. 2019

J Biomedical Materials Res

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This study aimed to develop a chitosan-based hydrogel containing a mixture of flavonoids isolated from the leaves of Passiflora edulis Sims and to evaluate its stability, antioxidant properties, and wound healing effects on cutaneous lesions in diabetic rats. in vitro studies were carried out to evaluate the biocompatibility and flavonoid release from the chitosan hydrogel. in vivo wound healing studies were conducted on male Wistar rats, where the injured tissue was removed for histological analysis and determination of lipid peroxidation, superoxide dismutase activity, and glutathione peroxidase activity. From the histological analysis and macroscopic evaluation of the contraction of the wounds, it was observed that the formulation presented wound healing properties. In addition, treatment of the wound with the formulation stimulated the antioxidant defense system, suggesting a beneficial effect during the treatment of skin lesions in diabetic rats, especially in the first few days after wounding. According to these results, we can conclude that the chitosan hydrogel containing the flavonoid analyzed in this study has potential use as dressings in the treatment of wounds. K E Y W O R D S antioxidant, chitosan, flavonoid, hydrogel, Passiflora edulis, wound healing

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supporting

confidence: 78%

mentioning

confidence: 99%

Development of a chitosan hydrogel containing flavonoids extracted from Passiflora edulis leaves and the evaluation of its antioxidant and wound healing properties for the treatment of skin lesions in diabetic mice

Soares

Campos

Ribeiro

et al. 2019

J Biomedical Materials Res

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“…The developed Apigenin (APN) loaded-GeG/CS hydrogel showed 87.15 ± 1.20 entrapment efficiency (%) and released 96.11% APN in 24 h. Further, the level of superoxide dismutase (SOD) and catalase was significantly improved in granuloma tissue of the APN-treated group. APN-GeG-CS hydrogels showed a higher healing effect in diabetic as well as normal wound tissues with significant antioxidant activity [192]. Further, GeG/HA spongy-like hydrogels accelerated wound closure rate, re-epithelization, and tissue neovascularization upon transplantation into full-thickness mice wounds.…”

Section: Wound Dressingmentioning

confidence: 91%

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

et al. 2020

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The engineering of tissues under a three-dimensional (3D) microenvironment is a great challenge and needs a suitable supporting biomaterial-based scaffold that may facilitate cell attachment, spreading, proliferation, migration, and differentiation for proper tissue regeneration or organ reconstruction. Polysaccharides as natural polymers promise great potential in the preparation of a three-dimensional artificial extracellular matrix (ECM) (i.e., hydrogel) via various processing methods and conditions. Natural polymers, especially gums, based upon hydrogel systems, provide similarities largely with the native ECM and excellent biological response. Here, we review the origin and physico-chemical characteristics of potentially used natural gums. In addition, various forms of scaffolds (e.g., nanofibrous, 3D printed-constructs) based on gums and their efficacy in 3D cell culture and various tissue regenerations such as bone, osteoarthritis and cartilage, skin/wound, retinal, neural, and other tissues are discussed. Finally, the advantages and limitations of natural gums are precisely described for future perspectives in tissue engineering and regenerative medicine in the concluding remarks.

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“…In this context, Shukla et al [ 137 ] developed hydrogels consisting of gellan gum and chitosan crosslinked with poly(ethylene glycol) loaded with apigenin. Their results on rat wound models showed a 96.11% release of the bioactive compound within 24 h and significant antioxidant activity.…”

Section: Wound Dressings In Skin Cancermentioning

confidence: 99%

Regenerative Wound Dressings for Skin Cancer

Pavel

Chircov

Rădulescu

et al. 2020

Cancers

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Skin cancer is considered the most prevalent cancer type globally, with a continuously increasing prevalence and mortality growth rate. Additionally, the high risk of recurrence makes skin cancer treatment among the most expensive of all cancers, with average costs estimated to double within 5 years. Although tumor excision is the most effective approach among the available strategies, surgical interventions could be disfiguring, requiring additional skin grafts for covering the defects. In this context, post-surgery management should involve the application of wound dressings for promoting skin regeneration and preventing tumor recurrence and microbial infections, which still represents a considerable clinical challenge. Therefore, this paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described.

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Fabrication of Apigenin loaded gellan gum–chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing

Cited by 105 publications

References 39 publications

Development of a chitosan hydrogel containing flavonoids extracted from Passiflora edulis leaves and the evaluation of its antioxidant and wound healing properties for the treatment of skin lesions in diabetic mice

Development of a chitosan hydrogel containing flavonoids extracted from Passiflora edulis leaves and the evaluation of its antioxidant and wound healing properties for the treatment of skin lesions in diabetic mice

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

Regenerative Wound Dressings for Skin Cancer

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